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Eur Heart J：β肾上腺素能刺激时IL-18触发心脏炎症和纤维化！

2017-05-28 xing.T MedSci原创

β-ARIL-18心脏炎症纤维化
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由此可见，急性β-AR刺激引起的心肌细胞中炎症小体依赖的IL-18激活可以触发细胞因子的级联反应、巨噬细胞浸润和病理性心肌重塑。在β-AR刺激早期阻断IL-18可成功地预防炎症反应和心脏损伤。

β-肾上腺素能受体（β-AR）在应激时快速地过度激活导致心脏炎症，是心脏损伤的主要因素。然而，急性β-AR刺激诱发心脏炎症的机制仍不清楚。近日，心血管领域权威杂志Eur Heart J上发表了一篇研究文章，研究人员旨在确定炎症小体/白细胞介素(IL)-18在β-AR刺激时心脏炎症级联反应触发和维持中起的关键作用。

研究人员采用雄性C57BL/6小鼠皮下注射单剂量的β-AR激动剂-异丙肾上腺素（ISO，5 毫克/公斤体重）或生理盐水。细胞因子阵列分析表明趋化因子主导的初始细胞因子上调，特别是在心脏收到β-AR刺激后，从而促进巨噬细胞早期浸润。进一步的调查显示在ISO诱导的β1-AR-ROS信号中，快速的炎症小体依赖的IL-18激活，但不仅仅是IL-1β，是关键的上游调节因子来增加心肌组织中趋化因子的表达。

研究人员发现胸痛患者血清去甲肾上腺素与IL-18水平呈正相关。基因敲除IL-18或上游的炎症小体组分NLRP3可以明显减轻ISO诱导的趋化因子的表达和巨噬细胞浸润。此外，IL-18中和抗体可以选择性地减弱ISO诱导的趋化因子、促炎细胞因子和粘附分子的表达，但不包括生长因子。此外，ISO治疗后早期阻断IL-18可以有效地减轻心脏炎症和纤维化。

由此可见，急性β-AR刺激引起的心肌细胞中炎症小体依赖的IL-18激活可以触发细胞因子的级联反应、巨噬细胞浸润和病理性心肌重塑。在β-AR刺激早期阻断IL-18可成功地预防炎症反应和心脏损伤。

原始出处：

Han Xiao,et al. IL-18 cleavage triggers cardiac inflammation and fibrosis upon β-adrenergic insult. Eur Heart J.https://doi.org/10.1093/eurheartj/ehx261

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    2017-06-03 咕宝宝

    酷

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    2017-06-08 xuyong523

    #肾上腺#

    0

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    2017-05-30 amyloid

    #肾上腺素#

    0

  4. 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channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c0a61971598, createdName=往日如昨, createdTime=Mon May 29 10:18:42 CST 2017, time=2017-05-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=203630, encodeId=783220363030, content=在β-AR刺激早期阻断IL-18可成功地预防炎症反应和心脏损伤, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7cJ6ejWUr2nIia8qOvAKNdLHr32Df6G8iaoaOx6pHaoiacwp26DaslxZHCGbibZhhCGven4rvmWP60GahtzgFjgCjR/0, createdBy=6b111703011, createdName=有备才能无患, createdTime=Sun May 28 16:09:29 CST 2017, time=2017-05-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=203621, encodeId=861f2036212d, content=正确用药可以挽救患者生命, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/05/25/aee510ed68ce4736e9fe4ec7d03c01b1.jpg, createdBy=ce892064652, createdName=楠博One, createdTime=Sun May 28 15:58:30 CST 2017, time=2017-05-28, status=1, ipAttribution=)]
    2017-05-30 zhaojie88

    #ART#

    0

  5. 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channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c0a61971598, createdName=往日如昨, createdTime=Mon May 29 10:18:42 CST 2017, time=2017-05-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=203630, encodeId=783220363030, content=在β-AR刺激早期阻断IL-18可成功地预防炎症反应和心脏损伤, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7cJ6ejWUr2nIia8qOvAKNdLHr32Df6G8iaoaOx6pHaoiacwp26DaslxZHCGbibZhhCGven4rvmWP60GahtzgFjgCjR/0, createdBy=6b111703011, createdName=有备才能无患, createdTime=Sun May 28 16:09:29 CST 2017, time=2017-05-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=203621, encodeId=861f2036212d, content=正确用药可以挽救患者生命, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/05/25/aee510ed68ce4736e9fe4ec7d03c01b1.jpg, createdBy=ce892064652, createdName=楠博One, createdTime=Sun May 28 15:58:30 CST 2017, time=2017-05-28, status=1, ipAttribution=)]
    2017-05-30 jjjiang0202

    #IL-1#

    0

  6. 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channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c0a61971598, createdName=往日如昨, createdTime=Mon May 29 10:18:42 CST 2017, time=2017-05-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=203630, encodeId=783220363030, content=在β-AR刺激早期阻断IL-18可成功地预防炎症反应和心脏损伤, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7cJ6ejWUr2nIia8qOvAKNdLHr32Df6G8iaoaOx6pHaoiacwp26DaslxZHCGbibZhhCGven4rvmWP60GahtzgFjgCjR/0, createdBy=6b111703011, createdName=有备才能无患, createdTime=Sun May 28 16:09:29 CST 2017, time=2017-05-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=203621, encodeId=861f2036212d, content=正确用药可以挽救患者生命, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/05/25/aee510ed68ce4736e9fe4ec7d03c01b1.jpg, createdBy=ce892064652, createdName=楠博One, createdTime=Sun May 28 15:58:30 CST 2017, time=2017-05-28, status=1, ipAttribution=)]
    2017-05-30 wangbingxhy

    #IL-18#

    0

  7. 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attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Tue May 30 05:43:00 CST 2017, time=2017-05-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1508184, encodeId=f4c415081845c, content=<a href='/topic/show?id=8d4596248e' target=_blank style='color:#2F92EE;'>#IL-1#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9624, encryptionId=8d4596248e, topicName=IL-1)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f6cf9946833, createdName=jjjiang0202, createdTime=Tue May 30 05:43:00 CST 2017, time=2017-05-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1553789, encodeId=ba931553e89d2, content=<a href='/topic/show?id=f3e6964ea7' target=_blank style='color:#2F92EE;'>#IL-18#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9647, encryptionId=f3e6964ea7, topicName=IL-18)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4bd614435976, createdName=wangbingxhy, createdTime=Tue May 30 05:43:00 CST 2017, time=2017-05-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1562541, encodeId=68b2156254124, content=<a href='/topic/show?id=f69d864413' target=_blank style='color:#2F92EE;'>#HEART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8644, encryptionId=f69d864413, topicName=HEART)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=80d715270048, createdName=slcumt, createdTime=Tue May 30 05:43:00 CST 2017, time=2017-05-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=203964, encodeId=1d5720396403, content=继续学习中谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c0a61971598, createdName=往日如昨, createdTime=Mon May 29 10:18:42 CST 2017, time=2017-05-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=203630, encodeId=783220363030, content=在β-AR刺激早期阻断IL-18可成功地预防炎症反应和心脏损伤, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7cJ6ejWUr2nIia8qOvAKNdLHr32Df6G8iaoaOx6pHaoiacwp26DaslxZHCGbibZhhCGven4rvmWP60GahtzgFjgCjR/0, createdBy=6b111703011, createdName=有备才能无患, createdTime=Sun May 28 16:09:29 CST 2017, time=2017-05-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=203621, encodeId=861f2036212d, content=正确用药可以挽救患者生命, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/05/25/aee510ed68ce4736e9fe4ec7d03c01b1.jpg, createdBy=ce892064652, createdName=楠博One, createdTime=Sun May 28 15:58:30 CST 2017, time=2017-05-28, status=1, ipAttribution=)]
    2017-05-30 slcumt

    #HEART#

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=206075, encodeId=3de22060e54b, content=酷, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLMsBhdLaRvXHhJPkRBlblTZocK3y0odD57cqfCzic7GAdTq7ghMfibzhwxs9MoGX0gDXRciciaX0vq6O/0, createdBy=a9372028891, createdName=咕宝宝, createdTime=Sat Jun 03 18:28:51 CST 2017, time=2017-06-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1895086, encodeId=3e7d189508616, content=<a href='/topic/show?id=ce478241e0b' target=_blank style='color:#2F92EE;'>#肾上腺#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82417, encryptionId=ce478241e0b, topicName=肾上腺)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8dba135, createdName=xuyong523, 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replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9647, encryptionId=f3e6964ea7, topicName=IL-18)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4bd614435976, createdName=wangbingxhy, createdTime=Tue May 30 05:43:00 CST 2017, time=2017-05-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1562541, encodeId=68b2156254124, content=<a href='/topic/show?id=f69d864413' target=_blank style='color:#2F92EE;'>#HEART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8644, encryptionId=f69d864413, topicName=HEART)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=80d715270048, createdName=slcumt, createdTime=Tue May 30 05:43:00 CST 2017, time=2017-05-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=203964, encodeId=1d5720396403, content=继续学习中谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c0a61971598, createdName=往日如昨, createdTime=Mon May 29 10:18:42 CST 2017, time=2017-05-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=203630, encodeId=783220363030, content=在β-AR刺激早期阻断IL-18可成功地预防炎症反应和心脏损伤, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7cJ6ejWUr2nIia8qOvAKNdLHr32Df6G8iaoaOx6pHaoiacwp26DaslxZHCGbibZhhCGven4rvmWP60GahtzgFjgCjR/0, createdBy=6b111703011, createdName=有备才能无患, createdTime=Sun May 28 16:09:29 CST 2017, time=2017-05-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=203621, encodeId=861f2036212d, content=正确用药可以挽救患者生命, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/05/25/aee510ed68ce4736e9fe4ec7d03c01b1.jpg, createdBy=ce892064652, createdName=楠博One, createdTime=Sun May 28 15:58:30 CST 2017, time=2017-05-28, status=1, ipAttribution=)]
    2017-05-29 往日如昨

    继续学习中谢谢

    0

  9. 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channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c0a61971598, createdName=往日如昨, createdTime=Mon May 29 10:18:42 CST 2017, time=2017-05-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=203630, encodeId=783220363030, content=在β-AR刺激早期阻断IL-18可成功地预防炎症反应和心脏损伤, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7cJ6ejWUr2nIia8qOvAKNdLHr32Df6G8iaoaOx6pHaoiacwp26DaslxZHCGbibZhhCGven4rvmWP60GahtzgFjgCjR/0, createdBy=6b111703011, createdName=有备才能无患, createdTime=Sun May 28 16:09:29 CST 2017, time=2017-05-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=203621, encodeId=861f2036212d, content=正确用药可以挽救患者生命, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/05/25/aee510ed68ce4736e9fe4ec7d03c01b1.jpg, createdBy=ce892064652, createdName=楠博One, createdTime=Sun May 28 15:58:30 CST 2017, time=2017-05-28, status=1, ipAttribution=)]
    2017-05-28 有备才能无患

    在β-AR刺激早期阻断IL-18可成功地预防炎症反应和心脏损伤

    0

  10. 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channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c0a61971598, createdName=往日如昨, createdTime=Mon May 29 10:18:42 CST 2017, time=2017-05-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=203630, encodeId=783220363030, content=在β-AR刺激早期阻断IL-18可成功地预防炎症反应和心脏损伤, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7cJ6ejWUr2nIia8qOvAKNdLHr32Df6G8iaoaOx6pHaoiacwp26DaslxZHCGbibZhhCGven4rvmWP60GahtzgFjgCjR/0, createdBy=6b111703011, createdName=有备才能无患, createdTime=Sun May 28 16:09:29 CST 2017, time=2017-05-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=203621, encodeId=861f2036212d, content=正确用药可以挽救患者生命, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/05/25/aee510ed68ce4736e9fe4ec7d03c01b1.jpg, createdBy=ce892064652, createdName=楠博One, createdTime=Sun May 28 15:58:30 CST 2017, time=2017-05-28, status=1, ipAttribution=)]
    2017-05-28 楠博One

    正确用药可以挽救患者生命

    0

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