AHA 2016:他汀类药物能改善心脏骤停患者的生存结局

2016-11-15 MedSci MedSci原创

根据在美国心脏协会科学会议上发表回顾性队列研究结果,对于院外心脏骤停患者,心脏骤停前使用他汀类药物与不使用他汀类药物比较,患者有更好的生存结局。 研究人员报告说,在糖尿病患者中,这种影响是特别明显的。 来自台湾的研究人员Ping-Hsun Yu博士和同事推测,心脏骤停前使用他汀类药物可能会改善结局,因为他汀类药物具有多效性,包括减少炎症相关的损伤和内皮功能障碍。 研究纳入了137

根据在美国心脏协会科学会议上发表回顾性队列研究结果,对于院外心脏骤停患者,心脏骤停前使用他汀类药物与不使用他汀类药物比较,患者有更好的生存结局。

研究人员报告说,在糖尿病患者中,这种影响是特别明显的。

来自台湾的研究人员Ping-Hsun Yu博士和同事推测,心脏骤停前使用他汀类药物可能会改善结局,因为他汀类药物具有多效性,包括减少炎症相关的损伤和内皮功能障碍。

研究纳入了137933名年龄18岁及以上的患者,他们的心脏骤停与创伤无关。其中9059名患者在心脏骤停前至少90天内使用了他汀类药物。使用倾向匹配方法,比较了8249名心脏骤停前服用了他汀类药物与24747没有服用他汀类药物患者的生存结局。

与没有服用他汀类药物的患者比较,心脏骤停前服用了他汀类药物的患者入院时有更高的生存率(OR = 1.19; 95% CI, 1.12-1.27),活着出院的可能性更大(OR = 1.47; 95% CI, 1.31-1.65),1年生存率更高(OR = 1.5; 95% CI, 1.31-1.71)。

当研究人员构建了一个logistic回归模型后,他们发现,心脏骤停前服用了他汀类药物是心脏骤停后1年生存率的独立预测因子(OR = 1.45; 95% CI, 1.26-1.68)。

根据亚组分析结果,他汀类药物对糖尿病患者心脏停搏后存活率的影响尤其显著。

原始出处:


Yu PH, et al. Presentation 15. Presented at: American Heart Association Scientific Sessions; Nov. 12-16, 2016; New Orleans.

Statin use confers better outcomes after cardiac arrest, particularly in patients with diabetes
.Healio.November 14, 2016

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  2. [GetPortalCommentsPageByObjectIdResponse(id=2044427, encodeId=ecc0204442e16, content=<a href='/topic/show?id=644725344b1' target=_blank style='color:#2F92EE;'>#他汀类药#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=25344, encryptionId=644725344b1, topicName=他汀类药)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTIibticIBly5jCSic5ZElW4He3rO4DMpUHUFaFX57OicNMnzckWaicBNeStwugWHFCuOdicoakApM4HGmtw/132, createdBy=f8672500006, createdName=ms6390871039024434, createdTime=Sat Feb 11 17:44:00 CST 2017, time=2017-02-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=156918, encodeId=4b9f156918ee, content=这是一项回顾性的研究还是前瞻性研究?, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20161224/IMG585DA5E26B9F44696.jpg, createdBy=565a98798, createdName=susice, createdTime=Sat Nov 19 22:32:15 CST 2016, time=2016-11-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1267343, encodeId=81df126e34375, content=<a href='/topic/show?id=922f21183d' target=_blank style='color:#2F92EE;'>#AHA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2118, encryptionId=922f21183d, topicName=AHA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bf3d82, createdName=zhaohui6731, createdTime=Thu Nov 17 10:44:00 CST 2016, time=2016-11-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=156080, encodeId=6037156080aa, content=不知道,文献中可以找到具体时间,先Mark一下,后面细读, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5K4PNicOvbHfgIficrsEKztlD5yv1UnCFhnFmFU9yv1RHLflMRibWrppbsiccfMB8tT9HCkAr3zL2zVml/0, createdBy=89da1604922, createdName=䖝二, createdTime=Wed Nov 16 10:12:02 CST 2016, time=2016-11-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=156037, encodeId=22fd15603e9d, content=学习了啊, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5e291719269, createdName=大旺旺, createdTime=Wed Nov 16 07:38:54 CST 2016, time=2016-11-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=155986, encodeId=c76915598602, content=怎么及时在骤停前给药呢?, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTKDtuWHtWxToIW0ZEvbHgDb4ibqQ1xaDQxcsHC5NIc2RJUxQgHJOLGEg8OUT345rDPmka4icU0WHPgw/0, createdBy=379f1941464, createdName=艳阳天2016, createdTime=Tue Nov 15 23:25:24 CST 2016, time=2016-11-15, status=1, ipAttribution=)]
    2016-11-19 susice

    这是一项回顾性的研究还是前瞻性研究?

    0

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    2016-11-17 zhaohui6731
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    2016-11-16 䖝二

    不知道,文献中可以找到具体时间,先Mark一下,后面细读

    0

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    2016-11-16 大旺旺

    学习了啊

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=2044427, encodeId=ecc0204442e16, content=<a href='/topic/show?id=644725344b1' target=_blank style='color:#2F92EE;'>#他汀类药#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=25344, encryptionId=644725344b1, topicName=他汀类药)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTIibticIBly5jCSic5ZElW4He3rO4DMpUHUFaFX57OicNMnzckWaicBNeStwugWHFCuOdicoakApM4HGmtw/132, createdBy=f8672500006, createdName=ms6390871039024434, createdTime=Sat Feb 11 17:44:00 CST 2017, time=2017-02-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=156918, encodeId=4b9f156918ee, content=这是一项回顾性的研究还是前瞻性研究?, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20161224/IMG585DA5E26B9F44696.jpg, createdBy=565a98798, createdName=susice, createdTime=Sat Nov 19 22:32:15 CST 2016, time=2016-11-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1267343, encodeId=81df126e34375, content=<a href='/topic/show?id=922f21183d' target=_blank style='color:#2F92EE;'>#AHA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2118, encryptionId=922f21183d, topicName=AHA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bf3d82, createdName=zhaohui6731, createdTime=Thu Nov 17 10:44:00 CST 2016, time=2016-11-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=156080, encodeId=6037156080aa, content=不知道,文献中可以找到具体时间,先Mark一下,后面细读, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5K4PNicOvbHfgIficrsEKztlD5yv1UnCFhnFmFU9yv1RHLflMRibWrppbsiccfMB8tT9HCkAr3zL2zVml/0, createdBy=89da1604922, createdName=䖝二, createdTime=Wed Nov 16 10:12:02 CST 2016, time=2016-11-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=156037, encodeId=22fd15603e9d, content=学习了啊, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5e291719269, createdName=大旺旺, createdTime=Wed Nov 16 07:38:54 CST 2016, time=2016-11-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=155986, encodeId=c76915598602, content=怎么及时在骤停前给药呢?, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTKDtuWHtWxToIW0ZEvbHgDb4ibqQ1xaDQxcsHC5NIc2RJUxQgHJOLGEg8OUT345rDPmka4icU0WHPgw/0, createdBy=379f1941464, createdName=艳阳天2016, createdTime=Tue Nov 15 23:25:24 CST 2016, time=2016-11-15, status=1, ipAttribution=)]
    2016-11-15 艳阳天2016

    怎么及时在骤停前给药呢?

    0

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