Diabetes Care:远端对称性多发性神经病与高血糖有关

2016-03-12 fsy 译 MedSci原创

以往的研究表明,代谢综合征与远端对称性多发性神经病(DSP)相关。该研究的目的是确定的这种影响的大小和所涉及的确切组分。在健康,衰老身体成分研究(前瞻性队列研究,参与者基线年龄70-79岁)中,研究人员确定了症状性DSP的患病率,由血糖状态(葡萄糖耐量试验)和额外的代谢综合征组分数量(更新国家胆固醇教育计划成人治疗组III的定义)进行分层。DSP通过神经性症状(问卷)加上三个确定测试的至少一种(重

以往的研究表明,代谢综合征与远端对称性多发性神经病(DSP)相关。该研究的目的是确定的这种影响的大小和所涉及的确切因素。

在健康、衰老身体成分研究(前瞻性队列研究,参与者基线年龄70-79岁)中,研究人员确定了症状性DSP的患病率,由血糖状态(葡萄糖耐量试验)和额外的代谢综合征组分数量(更新国家胆固醇教育计划成人治疗组III的定义)进行分层。DSP通过神经性症状(问卷)加上三个确定测试的至少一种(重单丝、腓传导速度和振动阈值)被定义。在横截面和纵向分析中,多变量逻辑和线性回归评估了代谢综合征组件和DSP的关联。

在进行神经检测的2382名参与者中(平均年龄73.5±2.9岁,38.2%为黑人,51.7%为女性),21.0%患有糖尿病,29.9%为糖尿病前期,52.8%有代谢综合征,11.1%为DSP患者。由血糖状态分层,DSP患病增加了代谢综合征部件的数量(P=0.03)。糖尿病(横截面模型,比值比[OR]1.65[95%CI1.18-2.31])和基线糖化血红蛋白(纵向模型,OR 1.42[95%CI1.15-1.75])是唯一的代谢综合征措施,与DSP显著相关。腰围和HDL与多发性继发性神经病变结果显著相关。

独立的血糖状况,症状性DSP在那些有额外的代谢综合征组分的患者中更为常见。然而,促使该关联的代谢综合症部分的问题,除了高血糖,仍不清楚。腰围大,低HDL可能与DSP有关,但还需要有更精确的代谢措施、更大规模的研究来证实。

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    2016-03-14 hbwxf
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    2016-03-14 axin012
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    2016-11-10 jml2009