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Neural Regen Res：Schlager小鼠可作为视网膜表型改变的模型

2020-03-05 不详 网络

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高血压是威胁视力的眼部疾病的一个高危因素。在这项研究中，我们首次研究了高血压BPH / 2J小鼠（Schlager小鼠）的视网膜神经结构，并将其与对照组的正常血压BPN / 3J菌株进行了比较。 BPH / 2J小鼠是一种选择性近交系小鼠品系，由于交感神经系统活性升高而发展为慢性高血压。与BPN / 3J菌株相比，高血压BPH / 2J小鼠在21周龄时神经视网膜外层完全丧失，这表明可能由高血压引起

高血压是威胁视力的眼部疾病的一个高危因素。在这项研究中，我们首次研究了高血压BPH / 2J小鼠（Schlager小鼠）的视网膜神经结构，并将其与对照组的正常血压BPN / 3J菌株进行了比较。

BPH / 2J小鼠是一种选择性近交系小鼠品系，由于交感神经系统活性升高而发展为慢性高血压。与BPN / 3J菌株相比，高血压BPH / 2J小鼠在21周龄时神经视网膜外层完全丧失，这表明可能由高血压引起的严重视力障碍疾病。为了阐明BPH / 2J菌株中的视网膜神经表型是否归因于BP升高，我们调查了4周龄BPN / 3J和BPH / 2J小鼠的神经视网膜。

初步结果首次显示，BPH / 2J菌株在年轻时会发生严重的视网膜神经损伤。我们的发现表明，BPH / 2J小鼠的视网膜表型可能是由于血压升高引起的，并且可能是由尚未确定的早期发作的自发突变或该菌株中发生的先天性缺陷引起的。

原始出处：

Lakshini Y. Herat, Aaron L. Magno, et al., The Schlager mouse as a model of altered retinal phenotype. Neural Regen Res. 2020 Mar; 15(3): 512–518.

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    2020-08-30 12498c32m68暂无昵称

    #GER#

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    2020-09-02 12498adam40暂无昵称

    #cHL#

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    2020-03-07 zutt

    #视网膜#

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    2020-03-07 marongnuan

    #HLA#

    0

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    2020-03-07 tastas

    #表型#

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=2021676, encodeId=7b9520216e608, content=<a href='/topic/show?id=31e8e9669d' target=_blank style='color:#2F92EE;'>#GER#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7966, encryptionId=31e8e9669d, topicName=GER)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=48732500158, createdName=12498c32m68暂无昵称, createdTime=Sun Aug 30 10:29:00 CST 2020, time=2020-08-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1985307, encodeId=55c1198530ee3, content=<a href='/topic/show?id=186046636e' target=_blank style='color:#2F92EE;'>#cHL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4663, encryptionId=186046636e, topicName=cHL)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f07c2500133, createdName=12498adam40暂无昵称, createdTime=Wed Sep 02 18:29:00 CST 2020, time=2020-09-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1270235, encodeId=836f12e023562, content=<a href='/topic/show?id=979690e33bd' target=_blank style='color:#2F92EE;'>#视网膜#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=90733, encryptionId=979690e33bd, topicName=视网膜)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=742793, createdName=zutt, createdTime=Sat Mar 07 12:29:00 CST 2020, time=2020-03-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1502062, encodeId=f2861502062c5, content=<a href='/topic/show?id=14a6894190' target=_blank style='color:#2F92EE;'>#HLA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8941, encryptionId=14a6894190, topicName=HLA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e72c9501412, createdName=marongnuan, createdTime=Sat Mar 07 12:29:00 CST 2020, time=2020-03-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1535259, encodeId=be38153525993, content=<a href='/topic/show?id=099f9020145' target=_blank style='color:#2F92EE;'>#表型#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=90201, encryptionId=099f9020145, topicName=表型)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9b6412593156, createdName=tastas, createdTime=Sat Mar 07 12:29:00 CST 2020, time=2020-03-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1047778, encodeId=ec93104e7781f, content=梅斯里提供了很多疾病的模型计算公式，赞一个！, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=CHANGE, createdTime=Fri Mar 06 00:29:00 CST 2020, time=2020-03-06, status=1, ipAttribution=)]
    2020-03-06 CHANGE

    梅斯里提供了很多疾病的模型计算公式，赞一个！

    0