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Nature：Treg细胞与代谢适应性有关

2013-07-26 Nature Nature

免疫TregmTORC1
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表达Foxp3的“调控性T细胞”(Treg) 在免疫耐受和动态平衡中起中心作用。在这项研究中，Hongbo Chi及其同事发现，mTORC1依赖型胆固醇生物合成对于Treg功能很重要，部分通过增加Treg“效应子”分子CTLA4 和ICOS发挥作用。这一发现说明，在免疫信号与细胞的代谢状态之间存在一个联系。 Zeng H, Yang K, Cloer C, Neale G, Vogel P,

表达Foxp3的“调控性T细胞”(Treg) 在免疫耐受和动态平衡中起中心作用。在这项研究中，Hongbo Chi及其同事发现，mTORC1依赖型胆固醇生物合成对于Treg功能很重要，部分通过增加Treg“效应子”分子CTLA4 和ICOS发挥作用。这一发现说明，在免疫信号与细胞的代谢状态之间存在一个联系。

Zeng H, Yang K, Cloer C, Neale G, Vogel P, Chi H.mTORC1 couples immune signals and metabolic programming to establish Treg-cell function.Nature. 2013 Jun 30. doi: 10.1038/nature12297. [Epub ahead of print]PMID:23812589

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    2013-08-17 liye789132251

    #Nat#

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    2014-03-29 HinsMax

    #代谢适应性#

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    2013-07-28 12498dd9m11暂无昵称

    #Treg细胞#

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    2013-07-28 12498484m48(暂无昵称)

    #Treg#

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    2013-07-28 huhuaidong394

    #适应性#

    0

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