Ophthalmologica:糖尿病黄斑水肿患者的眼房水中可溶性血管内皮生长因子受体(sVEGFR)和炎症因子的水平显著高于非糖尿病人!

2017-06-01 cuiguizhong MedSci原创

日本东京医科大学医学中心眼科系的Shimura M实验室在最新一期的Ophthalmologica上发表了他们近期的一项工作。他们测量了35例(37只眼)接受抗血管内皮生长因子(VEGF)治疗的糖尿病性黄斑水肿(DME)患者眼房水中可溶性血管内皮生长因子受体(sVEGFR)和炎性因子的水平。

日本东京医科大学医学中心眼科系的Shimura M实验室在最新一期的Ophthalmologica上发表了他们近期的一项工作。他们测量了35例(37只眼)接受抗血管内皮生长因子(VEGF)治疗的糖尿病性黄斑水肿(DME)患者眼房水中可溶性血管内皮生长因子受体(sVEGFR)和炎性因子的水平。

他们发现一个重要的现象,在糖尿病性黄斑水肿(DME)患者眼房水中,生长因子水平(VEGF,胎盘生长因子[PlGF]和血小板衍生生长因子AA [PDGF-AA]),sVEGFR-1和sVEGFR-2,可溶性细胞间粘附分子1,单核细胞趋化蛋白(MCP)-1 ,白细胞介素(IL)-6,-8,-12和-13,以及干扰素诱导型10-kDa蛋白(IP-10)均明显高于非糖尿病的对照组。 其中sVEGFR-2的水平与神经感觉视网膜的厚度以及生长因子(VEGF和PDGF-AA)和炎症因子(MCP-1,IL-6和IL-8)的水平显着相关。 三种生长因子(VEGF,PlGF和PDGF-AA)之间相关性很强,它们也与sVEGFR-1或sVEGFR-2和炎性因子(MCP-1,IL-6,IL-8和IP-10)的相关性很强。

这些发现表明,sVEGFRs和生长/炎症因子在DME中具有重要作用。他们的这项研究可以为治疗糖尿病黄斑水肿提供思路。

原始出处:

Noma, H., Mimura, T., Yasuda, K., Motohashi, R., Kotake, O., & Shimura, M. (2017). Aqueous Humor Levels of Soluble Vascular Endothelial Growth Factor Receptor and Inflammatory Factors in Diabetic Macular Edema. Ophthalmologica. doi:10.1159/000475603

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objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=64238, encryptionId=4ce26423802, topicName=水肿)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTKCRibWHQArPHdSkqP90U1HwwqlGeU7BUgzY240D3v2ibBDJ09ybkGkwOjxz7qRmngZaGlK1taX6hfA/132, createdBy=2e772500094, createdName=小华子, createdTime=Sat Jun 03 14:49:00 CST 2017, time=2017-06-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1368477, encodeId=f44b13684e70d, content=<a href='/topic/show?id=25aa1833e88' target=_blank style='color:#2F92EE;'>#VEGF#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=18337, encryptionId=25aa1833e88, topicName=VEGF)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=80ca273, createdName=fanweitanzhen, createdTime=Sat Jun 03 14:49:00 CST 2017, time=2017-06-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1407284, encodeId=78f9140e28400, content=<a href='/topic/show?id=d5b01834e3a' target=_blank style='color:#2F92EE;'>#VEGFR#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=18347, encryptionId=d5b01834e3a, topicName=VEGFR)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3d8d2627959, createdName=jml2010, createdTime=Sat Jun 03 14:49:00 CST 2017, time=2017-06-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1510904, encodeId=297d151090497, content=<a href='/topic/show?id=abd8103141b8' target=_blank style='color:#2F92EE;'>#黄斑水肿#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=103141, encryptionId=abd8103141b8, topicName=黄斑水肿)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8b9a10269982, createdName=xiay994456, createdTime=Sat Jun 03 14:49:00 CST 2017, time=2017-06-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1517957, encodeId=2306151e957a9, content=<a href='/topic/show?id=aa2269613cd' target=_blank style='color:#2F92EE;'>#生长因子#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=69613, encryptionId=aa2269613cd, topicName=生长因子)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3df311117154, createdName=12499e01m50暂无昵称, createdTime=Sat Jun 03 14:49:00 CST 2017, time=2017-06-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1518202, encodeId=402f15182029d, content=<a href='/topic/show?id=371de681325' target=_blank style='color:#2F92EE;'>#糖尿病黄斑水肿#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76813, encryptionId=371de681325, topicName=糖尿病黄斑水肿)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b88311125888, createdName=循证小兵, createdTime=Sat Jun 03 14:49:00 CST 2017, time=2017-06-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1525084, encodeId=b9d01525084ca, content=<a href='/topic/show?id=65e91031337f' target=_blank style='color:#2F92EE;'>#黄斑#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=103133, encryptionId=65e91031337f, topicName=黄斑)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=638b11619344, createdName=muzishouyi, createdTime=Sat Jun 03 14:49:00 CST 2017, time=2017-06-03, status=1, ipAttribution=)]
    2017-06-03 小华子
  5. 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  6. 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2017, time=2017-06-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1407284, encodeId=78f9140e28400, content=<a href='/topic/show?id=d5b01834e3a' target=_blank style='color:#2F92EE;'>#VEGFR#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=18347, encryptionId=d5b01834e3a, topicName=VEGFR)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=3d8d2627959, createdName=jml2010, createdTime=Sat Jun 03 14:49:00 CST 2017, time=2017-06-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1510904, encodeId=297d151090497, content=<a href='/topic/show?id=abd8103141b8' target=_blank style='color:#2F92EE;'>#黄斑水肿#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=103141, encryptionId=abd8103141b8, topicName=黄斑水肿)], attachment=null, 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replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76813, encryptionId=371de681325, topicName=糖尿病黄斑水肿)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b88311125888, createdName=循证小兵, createdTime=Sat Jun 03 14:49:00 CST 2017, time=2017-06-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1525084, encodeId=b9d01525084ca, content=<a href='/topic/show?id=65e91031337f' target=_blank style='color:#2F92EE;'>#黄斑#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=103133, encryptionId=65e91031337f, topicName=黄斑)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=638b11619344, createdName=muzishouyi, createdTime=Sat Jun 03 14:49:00 CST 2017, time=2017-06-03, status=1, ipAttribution=)]
    2017-06-03 jml2010
  7. 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    2017-06-03 muzishouyi

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