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mBio：浙江大学冯友军研究团发表病原菌的耐药性和致病性研究论文

2017-05-19 佚名 生物帮

病原菌:耐药性:致病性
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近日，国际微生物学旗舰刊物《mBio》杂志上在线发表了浙江大学医学院感染与免疫中心冯友军教授在细菌多粘菌素耐药MCR-2的播散与机制方面取得重要进展。研究文章题为“Deciphering MCR-2 Colistin Resistance”，这是继2016年在《PLOS Pathogens》和《mBio》上发表可水平转移粘菌素新型耐药基因MCR-1以来，在粘菌素耐药新机制研究上又一重大突破。冯友军

近日，国际微生物学旗舰刊物《mBio》杂志上在线发表了浙江大学医学院感染与免疫中心冯友军教授在细菌多粘菌素耐药MCR-2的播散与机制方面取得重要进展。研究文章题为“Deciphering MCR-2 Colistin Resistance”，这是继2016年在《PLOS Pathogens》和《mBio》上发表可水平转移粘菌素新型耐药基因MCR-1以来，在粘菌素耐药新机制研究上又一重大突破。冯友军教授为通讯作者。

多粘菌素是人医临床治疗多重耐药革兰氏阴性菌感染的最后一道防线。自从在2015年底，华南农业大学兽医微生物耐药性风险评估实验室的刘健华教授发现可水平转移的粘菌素耐药新基因mcr-1以来，短短一年多的时间，mcr-1已经在全球5大洲超过40多个国家检出。随后，在英国的农场中又发现了一个全新的亚型mcr-2。相比mcr-1，mcr-2仅在局部地区流行，其转座机制以及耐药机制也未必阐明，来自浙江大学医学院的这篇最新的报道，冯友军教授团队从头合成了该基因及周边序列，分析了该基因可能通过两个IS1595-类似的插入序列(ISEc69)形成的环状中间体进行传播，通过经典遗传学的方法发现与mcr-1类似，跨膜区和底物结合位点也是mcr-2介导粘菌素耐药性所必须的区域，而且两个基因都与天然产粘菌素的Paenibacili菌株的脂质体A转移酶非常相似，提示mcr-1和mcr-2都可能的起源于产粘菌素的细菌。研究的成功开展得益于华南农业大学刘雅红教授团队的通力合作！

冯友军教授长期从事病原菌的耐药性和致病性研究。近年来，其率领团队通过细菌遗传学、生物化学以及生物信息学等多种研究手段在致病菌的脂代谢调控等方向开展了较为系统的大量研究，在国际著名期刊PLoS Pathogens ， mBio 和Molecular Microbiology等发表了多篇高水平SCI论文。该团队紧跟国际上的热点问题，通过综合运用各种研究方法和手段率先阐明了mcr-1/mcr-2的作用机制，传播机制以及可能的起源，填补了相关研究领域的空白。

原始出处：

Sun J， Xu Y， Gao R， et al.Deciphering MCR-2 Colistin Resistance.MBio. 2017 May 9

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    2017-08-15 一闲

    #浙江大学#

    0

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    2017-07-01 sunylz

    #Bio#

    0

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    2017-06-01 cnxcy

    #致病性#

    0

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    2018-03-08 zjshifan_98647317

    #病原菌#

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1745680, encodeId=5eab1e4568044, content=<a href='/topic/show?id=73826552320' target=_blank style='color:#2F92EE;'>#浙江大学#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=65523, encryptionId=73826552320, topicName=浙江大学)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c35635545425, createdName=一闲, createdTime=Tue Aug 15 05:25:00 CST 2017, time=2017-08-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1917490, encodeId=0e02191e490d3, content=<a href='/topic/show?id=4f26341994' target=_blank style='color:#2F92EE;'>#Bio#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3419, encryptionId=4f26341994, topicName=Bio)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12de429, createdName=sunylz, createdTime=Sat Jul 01 12:25:00 CST 2017, time=2017-07-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1718830, encodeId=f6c01e1883061, content=<a href='/topic/show?id=d3e9864e750' target=_blank style='color:#2F92EE;'>#致病性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=86477, encryptionId=d3e9864e750, topicName=致病性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d36132650190, createdName=cnxcy, createdTime=Thu Jun 01 16:25:00 CST 2017, time=2017-06-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1739357, encodeId=57861e39357eb, content=<a href='/topic/show?id=3344e0820a0' target=_blank style='color:#2F92EE;'>#病原菌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=70820, encryptionId=3344e0820a0, topicName=病原菌)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=350334527944, createdName=zjshifan_98647317, createdTime=Thu Mar 08 05:25:00 CST 2018, time=2018-03-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=203396, encodeId=5a1c203396da, content=出现新的耐药基因, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/xkvRjYnJzzRJ2R0y7VhicibvkjPWHjIMmu4ZpKnE9cWAu4lVicS3uDUCfF4M4JWvrkrYfpb2KehPV0Ee29tPqyPEebBUibiaKhnvD/0, createdBy=f8412001184, createdName=惠映实验室, createdTime=Sun May 28 00:43:00 CST 2017, time=2017-05-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=202682, encodeId=5658202682fd, content=关注病原菌的耐药性研究。, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160806/IMG57A5698BDB0244113.jpg, createdBy=32a91358059, createdName=jyzxjiangqin, createdTime=Fri May 26 07:25:24 CST 2017, time=2017-05-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=201626, encodeId=a31320162677, content=学习了。谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20170701/IMG595791009FB761316.jpg, createdBy=abd01695121, createdName=吴教授, createdTime=Tue May 23 09:59:47 CST 2017, time=2017-05-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=200191, encodeId=d92e20019135, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib2JlGvwpAibiaovVhfA9DbO7X7JLGGjM4Cic6oMgxLdnuS9piaP9cnG2OwIbkzHvX0qzS1boibyYNqR5vHZu7HQs5EIB/0, createdBy=298d1398341, createdName=lou.minghong, createdTime=Sat May 20 04:05:28 CST 2017, time=2017-05-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=200167, encodeId=7b7b20016e1e, content=这文章要好好学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/xkvRjYnJzzRJ2R0y7VhicibvkjPWHjIMmu4ZpKnE9cWAu4lVicS3uDUCfF4M4JWvrkrYfpb2KehPV0Ee29tPqyPEebBUibiaKhnvD/0, createdBy=f8412001184, createdName=惠映实验室, createdTime=Sat May 20 01:13:53 CST 2017, time=2017-05-20, status=1, ipAttribution=)]
    2017-05-28 惠映实验室

    出现新的耐药基因

    0

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    2017-05-26 jyzxjiangqin

    关注病原菌的耐药性研究。

    0

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    2017-05-23 吴教授

    学习了。谢谢分享

    0

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    2017-05-20 lou.minghong

    学习

    0

  9. [GetPortalCommentsPageByObjectIdResponse(id=1745680, encodeId=5eab1e4568044, content=<a href='/topic/show?id=73826552320' target=_blank style='color:#2F92EE;'>#浙江大学#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=65523, encryptionId=73826552320, topicName=浙江大学)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=c35635545425, createdName=一闲, createdTime=Tue Aug 15 05:25:00 CST 2017, time=2017-08-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1917490, encodeId=0e02191e490d3, content=<a href='/topic/show?id=4f26341994' target=_blank style='color:#2F92EE;'>#Bio#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=3419, encryptionId=4f26341994, topicName=Bio)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=12de429, createdName=sunylz, createdTime=Sat Jul 01 12:25:00 CST 2017, time=2017-07-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1718830, encodeId=f6c01e1883061, content=<a href='/topic/show?id=d3e9864e750' target=_blank style='color:#2F92EE;'>#致病性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=86477, encryptionId=d3e9864e750, topicName=致病性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d36132650190, createdName=cnxcy, createdTime=Thu Jun 01 16:25:00 CST 2017, time=2017-06-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1739357, encodeId=57861e39357eb, content=<a href='/topic/show?id=3344e0820a0' target=_blank style='color:#2F92EE;'>#病原菌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=70820, encryptionId=3344e0820a0, topicName=病原菌)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=350334527944, createdName=zjshifan_98647317, createdTime=Thu Mar 08 05:25:00 CST 2018, time=2018-03-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=203396, encodeId=5a1c203396da, content=出现新的耐药基因, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/xkvRjYnJzzRJ2R0y7VhicibvkjPWHjIMmu4ZpKnE9cWAu4lVicS3uDUCfF4M4JWvrkrYfpb2KehPV0Ee29tPqyPEebBUibiaKhnvD/0, createdBy=f8412001184, createdName=惠映实验室, createdTime=Sun May 28 00:43:00 CST 2017, time=2017-05-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=202682, encodeId=5658202682fd, content=关注病原菌的耐药性研究。, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160806/IMG57A5698BDB0244113.jpg, createdBy=32a91358059, createdName=jyzxjiangqin, createdTime=Fri May 26 07:25:24 CST 2017, time=2017-05-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=201626, encodeId=a31320162677, content=学习了。谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20170701/IMG595791009FB761316.jpg, createdBy=abd01695121, createdName=吴教授, createdTime=Tue May 23 09:59:47 CST 2017, time=2017-05-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=200191, encodeId=d92e20019135, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib2JlGvwpAibiaovVhfA9DbO7X7JLGGjM4Cic6oMgxLdnuS9piaP9cnG2OwIbkzHvX0qzS1boibyYNqR5vHZu7HQs5EIB/0, createdBy=298d1398341, createdName=lou.minghong, createdTime=Sat May 20 04:05:28 CST 2017, time=2017-05-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=200167, encodeId=7b7b20016e1e, content=这文章要好好学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/xkvRjYnJzzRJ2R0y7VhicibvkjPWHjIMmu4ZpKnE9cWAu4lVicS3uDUCfF4M4JWvrkrYfpb2KehPV0Ee29tPqyPEebBUibiaKhnvD/0, createdBy=f8412001184, createdName=惠映实验室, createdTime=Sat May 20 01:13:53 CST 2017, time=2017-05-20, status=1, ipAttribution=)]
    2017-05-20 惠映实验室

    这文章要好好学习

    0