Diabetes Care：T1DM增加青年动脉粥样硬化风险

1型糖尿病增加成人颈动脉内膜-中层厚度(IMT)。为了评价青年1型糖尿病患者的IMT，来自辛辛那提儿童医院和美国辛辛那提大学的Urbina博士等人进行了一项研究，研究发现青年1型糖尿病患者颈动脉IMT增厚。研究结果在线发表于2013年4月5日的美国《糖尿病护理》(Diabetes Care)杂志上。

研究对象为402例1型糖尿病参与者，以及经年龄、性别、种族和民族匹配的206例对照，参与者平均年龄18.9±3.3岁(50%男性，82.7%为非西班牙裔白人)。测定人体测量学和实验室生化检查指标、血压和IMT。采用ANCOVA协方差分析评价控制人口学特征危险因素、心血管危险因素和HbA1c后的差异。

结果显示，青年1型糖尿病患者颈动脉球部IMT较对照组增厚，校正人口学特征和心血管危险因素后，仍有显著性差异。年龄、性别、肥胖和收缩压始终是IMT的重要决定因素。校正HbA1c后可消除糖尿病组与对照组颈动脉球部IMT差异，提示这种差异可归结为血糖控制不佳。

研究表明，处于高危心血管疾病的1型糖尿病患者颈动脉IMT增加。更好地控制糖尿病对于预防动脉粥样硬化进展是必要的。

与动脉粥样硬化相关的拓展阅读：

• J Psychiatr Res：初诊抑郁症与动脉粥样硬化相关
• Diabetes Care：T1DM患者维生素D代谢受损与动脉粥样硬化没有相关性
• Diabetes Care：甘精胰岛素轻度降低动脉粥样硬化风险
• EMBO：揭示单核细胞迁移至血管壁导致动脉粥样硬化机制
• J BIOL CHEM:发现抑制动脉粥样硬化新分子信号途径
• JAMA：减少动脉粥样硬化性血栓形成实现持续健康
更多信息请点击：有关动脉粥样硬化更多资讯

Effect of Type 1 Diabetes Mellitus on Carotid Structure and Function in Adolescents and Young Adults: The SEARCH CVD Study.
OBJECTIVE
Type 1 diabetes mellitus causes increased carotid intima-media thickness (IMT) in adults. We evaluated IMT in young subjects with type 1 diabetes.RESEARCH DESIGN AND
METHODS
Participants with type 1 diabetes (N = 402) were matched to controls (N = 206) by age, sex, and race or ethnicity. Anthropometric and laboratory values, blood pressure, and IMT were measured. ANCOVA was used to assess differences controlling for demographic risk factors, cardiovascular risk factors, and HbA1c.
RESULTS
Subjects were 18.9 ± 3.3 years old (50% male, 82.7% non-Hispanic white). Youth with type 1 diabetes had thicker bulb IMT, which remained significantly different after adjustment for demographics and cardiovascular risk factors. Age, sex, adiposity, and systolic blood pressure were consistent significant determinants of IMT. Adjustment for HbA1c eliminated the difference, suggesting the difference was attributable to poor glycemic control.
CONCLUSIONS
Carotid IMT may be increased in youth with type 1 diabetes at high risk for cardiovascular disease. Better control of diabetes may be essential in preventing progression of atherosclerosis.