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Nature: 免疫和神经细胞共同对抗肠道感染

2017-09-07 MedSci MedSci原创

免疫和神经细胞肠道感染
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威尔康奈尔医学院的一项新研究表明，肠道中的神经细胞对人体免疫系统的免疫应答起着至关重要的作用。这项于9月6日发表在《自然》杂志上的研究表明，免疫系统和神经系统共同进化来应对传染性威胁。这意味着科学家寻求治疗诸如炎症性肠病或哮喘的疾病涉及过度免疫系统反应的方法也可能需要解决神经系统的作用。"免疫系统和神经系统不能独立行动，"吉尔·罗伯茨研究所炎症性肠病研究主任大卫·阿提斯和威尔·康奈尔医学院的迈克尔

威尔康奈尔医学院的一项新研究表明，肠道中的神经细胞对人体免疫系统的免疫应答起着至关重要的作用。这项于9月6日发表在《自然》杂志上的研究表明，免疫系统和神经系统共同进化来应对传染性威胁。这意味着科学家寻求治疗诸如炎症性肠病或哮喘的疾病涉及过度免疫系统反应的方法也可能需要解决神经系统的作用。"免疫系统和神经系统不能独立行动，"吉尔·罗伯茨研究所炎症性肠病研究主任大卫·阿提斯和威尔·康奈尔医学院的迈克尔·科斯免疫学教授说。"他们在一起工作。"许多免疫系统细胞位于肠道内壁，它们可以防御寄生虫和其他感染。它还含有神经细胞。该研究的主要作者、罗伯茨研究所的博士后研究员克里斯托夫·克洛泽(Christoph Klose)发现，肠道中的免疫系统细胞，称为第二组先天淋巴细胞(ILC2s)，与被称为胆碱能神经元的神经细胞相互交织在一起。"这些家伙像探戈一样跳舞，"克洛泽说。这些细胞的接近使研究人员怀疑他们是否在交流。那时他们发现，ILC2细胞有一种叫做神经介素U的受体（NMU），它可以作为神经细胞的信使。在实验室的实验中，研究人员发现，将ILC2细胞暴露于NMU会导致ILC2细胞迅速繁殖，并分泌一种叫做细

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    2018-06-08 liye789132251

    #Nat#

    0

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    2017-09-09 medscijoin

    #肠道感染#

    0

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    2017-09-09 仁医06

    #神经细胞#

    0

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    2017-09-08 忠诚向上

    好好看下.内容丰富

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1882433, encodeId=502a18824335c, content=<a href='/topic/show?id=3b2112532d8' target=_blank style='color:#2F92EE;'>#Nat#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12532, encryptionId=3b2112532d8, topicName=Nat)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e6f107, createdName=liye789132251, createdTime=Fri Jun 08 23:03:00 CST 2018, time=2018-06-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1459979, encodeId=194614599e973, content=<a href='/topic/show?id=f1c78168032' target=_blank style='color:#2F92EE;'>#肠道感染#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81680, encryptionId=f1c78168032, topicName=肠道感染)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=69b16221893, createdName=medscijoin, createdTime=Sat Sep 09 14:03:00 CST 2017, time=2017-09-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1489541, encodeId=273514895412b, content=<a href='/topic/show?id=362fe4482f1' target=_blank style='color:#2F92EE;'>#神经细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=74482, encryptionId=362fe4482f1, topicName=神经细胞)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=55683, createdName=仁医06, createdTime=Sat Sep 09 14:03:00 CST 2017, time=2017-09-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=241661, encodeId=eb43241661b3, content=好好看下.内容丰富, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Fri Sep 08 07:53:01 CST 2017, time=2017-09-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=241635, encodeId=abc724163533, content=谢谢.学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ad4c106013, createdName=Drhzm308, createdTime=Fri Sep 08 07:09:37 CST 2017, time=2017-09-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=241625, encodeId=4f822416252b, content=谢谢分享.学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6Nx0VGA4QMDzOP8oAgnV4h51EjSfehJ9QxyiaSmw8PB56BhY8KXFSxHCibXrzcy4abrzSibXQPxJ9kzrLcJyhhB8a/0, createdBy=1d3b1672603, createdName=明月清辉, createdTime=Fri Sep 08 07:01:32 CST 2017, time=2017-09-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=241612, encodeId=617d24161279, content=学习.谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyhb9xDeHojCicsdRdyC3XXdGk2ib9yLypZuHN06WeW4HO8WN0GGrgEfvnTX8gsckof05GHOU5OM4Mvx/0, createdBy=9cee1982656, createdName=执着追梦, createdTime=Fri Sep 08 06:41:40 CST 2017, time=2017-09-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=241604, encodeId=c20824160495, content=学习了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2017/04/21/72142930668371951a41ef4ea4b233e6.jpg, createdBy=dcbc1715228, createdName=刘煜, createdTime=Fri Sep 08 06:30:11 CST 2017, time=2017-09-08, status=1, ipAttribution=)]
    2017-09-08 Drhzm308

    谢谢.学习了

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1882433, encodeId=502a18824335c, content=<a href='/topic/show?id=3b2112532d8' target=_blank style='color:#2F92EE;'>#Nat#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12532, encryptionId=3b2112532d8, topicName=Nat)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e6f107, createdName=liye789132251, createdTime=Fri Jun 08 23:03:00 CST 2018, time=2018-06-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1459979, encodeId=194614599e973, content=<a href='/topic/show?id=f1c78168032' target=_blank style='color:#2F92EE;'>#肠道感染#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81680, encryptionId=f1c78168032, topicName=肠道感染)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=69b16221893, createdName=medscijoin, createdTime=Sat Sep 09 14:03:00 CST 2017, time=2017-09-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1489541, encodeId=273514895412b, content=<a href='/topic/show?id=362fe4482f1' target=_blank style='color:#2F92EE;'>#神经细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=74482, encryptionId=362fe4482f1, topicName=神经细胞)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=55683, createdName=仁医06, createdTime=Sat Sep 09 14:03:00 CST 2017, time=2017-09-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=241661, encodeId=eb43241661b3, content=好好看下.内容丰富, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Fri Sep 08 07:53:01 CST 2017, time=2017-09-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=241635, encodeId=abc724163533, content=谢谢.学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ad4c106013, createdName=Drhzm308, createdTime=Fri Sep 08 07:09:37 CST 2017, time=2017-09-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=241625, encodeId=4f822416252b, content=谢谢分享.学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6Nx0VGA4QMDzOP8oAgnV4h51EjSfehJ9QxyiaSmw8PB56BhY8KXFSxHCibXrzcy4abrzSibXQPxJ9kzrLcJyhhB8a/0, createdBy=1d3b1672603, createdName=明月清辉, createdTime=Fri Sep 08 07:01:32 CST 2017, time=2017-09-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=241612, encodeId=617d24161279, content=学习.谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyhb9xDeHojCicsdRdyC3XXdGk2ib9yLypZuHN06WeW4HO8WN0GGrgEfvnTX8gsckof05GHOU5OM4Mvx/0, createdBy=9cee1982656, createdName=执着追梦, createdTime=Fri Sep 08 06:41:40 CST 2017, time=2017-09-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=241604, encodeId=c20824160495, content=学习了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2017/04/21/72142930668371951a41ef4ea4b233e6.jpg, createdBy=dcbc1715228, createdName=刘煜, createdTime=Fri Sep 08 06:30:11 CST 2017, time=2017-09-08, status=1, ipAttribution=)]
    2017-09-08 明月清辉

    谢谢分享.学习了

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=1882433, encodeId=502a18824335c, content=<a href='/topic/show?id=3b2112532d8' target=_blank style='color:#2F92EE;'>#Nat#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12532, encryptionId=3b2112532d8, topicName=Nat)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e6f107, createdName=liye789132251, createdTime=Fri Jun 08 23:03:00 CST 2018, time=2018-06-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1459979, encodeId=194614599e973, content=<a href='/topic/show?id=f1c78168032' target=_blank style='color:#2F92EE;'>#肠道感染#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81680, encryptionId=f1c78168032, topicName=肠道感染)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=69b16221893, createdName=medscijoin, createdTime=Sat Sep 09 14:03:00 CST 2017, time=2017-09-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1489541, encodeId=273514895412b, content=<a href='/topic/show?id=362fe4482f1' target=_blank style='color:#2F92EE;'>#神经细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=74482, encryptionId=362fe4482f1, topicName=神经细胞)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=55683, createdName=仁医06, createdTime=Sat Sep 09 14:03:00 CST 2017, time=2017-09-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=241661, encodeId=eb43241661b3, content=好好看下.内容丰富, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Fri Sep 08 07:53:01 CST 2017, time=2017-09-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=241635, encodeId=abc724163533, content=谢谢.学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ad4c106013, createdName=Drhzm308, createdTime=Fri Sep 08 07:09:37 CST 2017, time=2017-09-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=241625, encodeId=4f822416252b, content=谢谢分享.学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6Nx0VGA4QMDzOP8oAgnV4h51EjSfehJ9QxyiaSmw8PB56BhY8KXFSxHCibXrzcy4abrzSibXQPxJ9kzrLcJyhhB8a/0, createdBy=1d3b1672603, createdName=明月清辉, createdTime=Fri Sep 08 07:01:32 CST 2017, time=2017-09-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=241612, encodeId=617d24161279, content=学习.谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyhb9xDeHojCicsdRdyC3XXdGk2ib9yLypZuHN06WeW4HO8WN0GGrgEfvnTX8gsckof05GHOU5OM4Mvx/0, createdBy=9cee1982656, createdName=执着追梦, createdTime=Fri Sep 08 06:41:40 CST 2017, time=2017-09-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=241604, encodeId=c20824160495, content=学习了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2017/04/21/72142930668371951a41ef4ea4b233e6.jpg, createdBy=dcbc1715228, createdName=刘煜, createdTime=Fri Sep 08 06:30:11 CST 2017, time=2017-09-08, status=1, ipAttribution=)]
    2017-09-08 执着追梦

    学习.谢谢分享

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=1882433, encodeId=502a18824335c, content=<a href='/topic/show?id=3b2112532d8' target=_blank style='color:#2F92EE;'>#Nat#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12532, encryptionId=3b2112532d8, topicName=Nat)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e6f107, createdName=liye789132251, createdTime=Fri Jun 08 23:03:00 CST 2018, time=2018-06-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1459979, encodeId=194614599e973, content=<a href='/topic/show?id=f1c78168032' target=_blank style='color:#2F92EE;'>#肠道感染#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=81680, encryptionId=f1c78168032, topicName=肠道感染)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=69b16221893, createdName=medscijoin, createdTime=Sat Sep 09 14:03:00 CST 2017, time=2017-09-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1489541, encodeId=273514895412b, content=<a href='/topic/show?id=362fe4482f1' target=_blank style='color:#2F92EE;'>#神经细胞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=74482, encryptionId=362fe4482f1, topicName=神经细胞)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=55683, createdName=仁医06, createdTime=Sat Sep 09 14:03:00 CST 2017, time=2017-09-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=241661, encodeId=eb43241661b3, content=好好看下.内容丰富, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=45101626056, createdName=忠诚向上, createdTime=Fri Sep 08 07:53:01 CST 2017, time=2017-09-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=241635, encodeId=abc724163533, content=谢谢.学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ad4c106013, createdName=Drhzm308, createdTime=Fri Sep 08 07:09:37 CST 2017, time=2017-09-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=241625, encodeId=4f822416252b, content=谢谢分享.学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6Nx0VGA4QMDzOP8oAgnV4h51EjSfehJ9QxyiaSmw8PB56BhY8KXFSxHCibXrzcy4abrzSibXQPxJ9kzrLcJyhhB8a/0, createdBy=1d3b1672603, createdName=明月清辉, createdTime=Fri Sep 08 07:01:32 CST 2017, time=2017-09-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=241612, encodeId=617d24161279, content=学习.谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyhb9xDeHojCicsdRdyC3XXdGk2ib9yLypZuHN06WeW4HO8WN0GGrgEfvnTX8gsckof05GHOU5OM4Mvx/0, createdBy=9cee1982656, createdName=执着追梦, createdTime=Fri Sep 08 06:41:40 CST 2017, time=2017-09-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=241604, encodeId=c20824160495, content=学习了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2017/04/21/72142930668371951a41ef4ea4b233e6.jpg, createdBy=dcbc1715228, createdName=刘煜, createdTime=Fri Sep 08 06:30:11 CST 2017, time=2017-09-08, status=1, ipAttribution=)]
    2017-09-08 刘煜

    学习了谢谢分享

    0