J Intern Med:警惕!无烟烟草增加2型糖尿病风险

2017-04-13 选题审校:顾歆纯 编辑:常路 环球医学编译

专家点评:本研究再次支持了尼古丁增加2型糖尿病风险的结论。提示使用含有尼古丁的香烟替代物并不能减少2型糖尿病的发病率,为患者教育提供理论依据。

一些大烟草公司近年纷纷推出不产生烟的新型无烟烟草制品,并宣传说它们比普通香烟危害小。2017年4月,发表在《J Intern Med.》的一项研究调查了瑞典无烟烟草(snus)使用和2型糖尿病风险之间的关系。结果表明,较高的消耗snus是2型糖尿病的风险因素。

背景:吸烟和尼古丁暴露会增加胰岛素抵抗和2型糖尿病的风险。瑞典无烟烟草(snus)的尼古丁含量较高,并在北欧国家广泛流行,但是几乎没有研究调查了snus的使用与糖尿病风险之间的相关性。

目的:旨在使用5个队列的汇总数据探讨snus使用和2型糖尿病风险之间的关系。

方法:本分析基于1990~2013年进行的前瞻性研究,这些研究纳入了54531名从不吸烟的男性和2441名2型糖尿病病例,这些研究对象通过筛查、自我报告和医院及处方登记鉴别出来。研究人员评估了风险比(HR)及其95%置信区间(CI),并调整了年龄、体重指数、教育水平、饮酒和体育运动。

结果:与不吸烟者相比,目前snus使用者的2型糖尿病的HR为1.15(95% CI,1.00~1.32)。每周消耗5~6包snus的个体中,HR为1.42(95% CI,1.07~1.87),每周消耗≥7包者,HR为1.68(95% CI,1.17~2.41)。每周每额外消耗一包snus,将产生1.08的HR(95% CI,1.01~1.16)。

结论:结果表明,较高的消耗snus是2型糖尿病的风险因素。该风险与吸烟者相似,这意味着吸烟者不会因转换到snus而降低他们的2型糖尿病风险。结果也支持了尼古丁可增加2型糖尿病风险的观念。

原始出处:Carlsson S,et al.Smokeless tobacco (snus) is associated with an increased risk of type 2 diabetes: results from five pooled cohorts.J Intern Med. 2017 Apr;281(4):398-406. doi: 10.1111/joim.12592. Epub 2017 Feb 6.

(专家点评:本研究再次支持了尼古丁增加2型糖尿病风险的结论。提示使用含有尼古丁的香烟替代物并不能减少2型糖尿病的发病率,为患者教育提供理论依据。)


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    2017-04-15 mnda
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    2017-04-14 wen2009

    电子烟吗

    0

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    2017-04-13 绛珠草小姐

    学习了,谢谢分享

    0