Science:BioNTech针对实体瘤的新型CAR-T疗法在小鼠模型中使肿瘤完全消退

2020-01-03 不详 MedSci原创

BioNTech宣布其针对实体瘤的新型CAR-T疗法的研究发表在Science杂志上,题目为"An RNA vaccine drives expansion and efficacy of claudin-CAR-T cells against solid tumors",报道了BioNTech的首个CAR-T产品候选物BNT211的临床前概念验证数据,这是一种针对癌胚细胞Claudin 6(CL

BioNTech宣布其针对实体瘤的新型CAR-T疗法的研究发表在Science杂志上,题目为"An RNA vaccine drives expansion and efficacy of claudin-CAR-T cells against solid tumors",报道了BioNTech的首个CAR-T产品候选物BNT211的临床前概念验证数据,这是一种针对癌胚细胞Claudin 6(CLDN6)的自体CAR-T细胞疗法。

尽管CAR-T细胞疗法已在血液癌症中显示出显着的临床疗效,但它仍在实体瘤中面临重大挑战,包括癌症特异性实体肿瘤靶标很少、CAR-T细胞向实体瘤中的浸润效率低以及CAR -T细胞的持久性不足。

BioNTech旨在通过靶向CLDN6(一种在多种实体瘤中表达的新型肿瘤特异性抗原),并与RNA疫苗相结合以促进体内CAR-T细胞的扩增、持久性和功效。

研究数据显示,在移植瘤小鼠体内,CLDN6-CAR-T细胞疗法在治疗开始后的两周内证明了肿瘤的完全消退。此外,与CARVac的组合可改善体内 CAR-T细胞的浸润、增殖和扩增,即使使用亚治疗性剂量的CAR-T也可使肿瘤消退。CARVac还成功应用于靶向泛癌抗原CLDN18.2和CD19的CAR-T细胞。

BioNTech计划今年开展BNT211针对卵巢癌、睾丸癌、子宫癌和肺癌在内的实体瘤中的第1/2期临床试验。

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    2020-11-17 仁者大医
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    2020-08-30 sunylz
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    2020-01-05 jichang
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    2020-01-03 CHANGE

    梅斯里提供了很多疾病的模型计算公式,赞一个!

    0

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