Psychiatry Res：SOD等或预测精神分裂症急性期严重程度

　　中国台湾学者的一项研究提示，超氧化物歧化酶（SOD）、谷胱甘肽过氧化物酶（GPx）和谷胱甘肽（GSH）可能是精神分裂症急性期严重程度的预测指标。此外，在接受为期4周治疗女性患者中，抗精神病药物可能会影响血清GPx活性。该研究论文3月15日在线发表于《精神病学研究》（Psychiatry Res）杂志。

　　该研究的目的是在精神分裂症急性期患者中探讨氧化应激标志物的血清水平或活动，并评估治疗后SOD、过氧化氢酶（CAT）、GPx、GSH和硫代巴比妥酸反应物质（TBARS）的变化。

　　研究连续纳入了41例精神分裂症急性期患者，其中27例患者接受了为期4周的抗精神病药物治疗和随访。血清氧化应激标志物采用检测试剂盒来测定。

　　结果发现，在精神分裂症急性期患者中，阳性和阴性症状量表（PANSS）总评分与血清GPx活性和GSH水平呈显著负相关性，与血清SOD活性呈正相关性。此外，血清GPx活性与GSH水平呈正相关性，与SOD活性呈负相关性。研究还发现，血清SOD活性与急性期患者的TBARS水平呈显著负相关性。此外，研究发现，仅在接受为期4周治疗的女性患者中，GPx活性显著增强。

与精神分裂相关的拓展阅读：

• JAMA Psychiatry：饮食补充剂或可改善精神分裂症症状
• Neuron：李卫东等揭示精神分裂症基因对人脑影响机制
• 加拿大精神分裂症发病率远超国际平均水平
• FDA批准阿立哌唑治疗精神分裂症
• PNAS：自闭症和精神分裂症的最新研究
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Changes in oxidative stress markers in patients with schizophrenia: The effect of antipsychotic drugs

Abstract 

The aim of this study was to investigate the serum levels or activities of oxidative stress markers in patients with schizophrenia in acute phase and evaluate the changes in superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), glutathione (GSH) and thiobarbituric acid-reactive substances (TBARS) after treatment. We consecutively enrolled 41 patients with schizophrenia in acute phase, and 27 patients were followed up with a 4-week antipsychotic treatment. Serum oxidative stress markers were measured with assay kits. We found that Positive and Negative Syndrome Scale (PANSS) total scores were significantly negatively correlated with serum GPx activity and GSH levels and positively correlated with serum SOD activity in patients with schizophrenia in acute phase. In addition, serum GPx activity had a positive correlation with GSH levels and negative correlation with SOD activity. We also found that serum SOD activity was significantly negatively correlated with TBARS levels in patients in acute phase. Furthermore, we found significantly increased changes only in GPx activity in female patients receiving the 4-week treatment (P=0.006). In conclusion, our results suggest that SOD, GPX and GSH might be indicators of schizophrenia severity in acute phase. Furthermore, antipsychotic drugs might affect serum GPx activity in female patients receiving the 4-week treatment.