Hypertension:多胎妊娠、先兆子痫与心血管疾病

2020-06-02 MedSci原创 MedSci原创

与首次单胎妊娠先兆子痫相反,首次多胎妊娠先兆子痫与未来CVD的风险增加无关。

近日,心血管权威杂志Hypertension上发表了一篇研究文章,这项基于瑞典登记的队列研究确定了先兆子痫和多胎妊娠对妇女晚年罹患心血管疾病(CVD)的单独和共同效应。

该研究纳入了 892425名1950年至1971年间出生且在1973年至2010年期间首次分娩的女性,这些参与者经瑞典医疗出生登记中心进行确认。通过与“国家患者和死亡原因登记中心”建立联系,获得了参与者的CVD综合结局。Cox比例风险回归用于评估单胎或多胎妊娠先兆子痫妇女的CVD风险,调整了潜在的混杂因素,并计算调整后的风险比。

与单胎妊娠而无先兆子痫的妇女(对照组)相比,单胎妊娠先兆子痫妇女发生CVD的风险增加(调整后的风险比为1.75 [95%CI为1.64-1.86])。多胎妊娠而无先兆子痫或先兆子痫的妇女未来发生CVD的风险没有增加(调整后的风险比分别为0.94 [95%CI为0.79-1.10]和1.25 [95%CI为0.83-1.86])。

与首次单胎妊娠先兆子痫相反,首次多胎妊娠先兆子痫与未来CVD的风险增加无关。这可能支持以下理论:多胎妊娠时先兆子痫更经常发生,这是由于与妊娠相关的孕妇心血管系统负担增加和胎盘释放的炎症因子过多所致,而非女性潜在的心血管表型。

原始出处:

Lina Bergman.et al.Multi-Fetal Pregnancy, Preeclampsia, and Long-Term Cardiovascular Disease.Hypertension.2020.https://www.ahajournals.org/doi/10.1161/HYPERTENSIONAHA.120.14860

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    2020-10-02 feather89
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    2020-08-07 咻凡

    这个杂志可以投吗?

    0

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