BMC Med:每天静坐多长时间会折损寿命?

2018-07-16 吴星 环球医学

如今,久坐的生活方式在成人中很普遍。其坏处不胜枚举:可能导致心血管疾病、2型糖尿病甚至癌症。而且,如果姿势不对,脊椎和脖颈更是积久成伤。静坐时间(ST)的延长越来越多地被认为是危害公共健康的严重问题,并且公共健康指南中已经开始出现建议,所有成人都应减少ST。

如今,久坐的生活方式在成人中很普遍。其坏处不胜枚举:可能导致心血管疾病、2型糖尿病甚至癌症。而且,如果姿势不对,脊椎和脖颈更是积久成伤。静坐时间(ST)的延长越来越多地被认为是危害公共健康的严重问题,并且公共健康指南中已经开始出现建议,所有成人都应减少ST。

为了对久坐生活方式的健康危害进行筛查和监测,并制定切实可行的干预策略和循证建议,确定每天ST的量的临界值或极限至关重要,超过这个限值会导致健康受损。

2018年5月,发表在《BMC Med》的一项由中国台湾和英国学者进行的涉及超过100万名参与者的Meta回归分析,旨在量化18~64岁成人的每日ST和全因死亡率之间的剂量效应关系,并探讨达到健康受损时的临界点。研究者也检测了使用自我报告ST的研究和基于设备的ST研究之间是否存在差异。

通过MEDLINE、PubMed、Scopus、Web of Science和Google学术数据库检索提供了每日ST(暴露)对全因死亡率(结局)影响评估值的前瞻性队列研究,截止时间为2018年1月。使用随机效应meta回归模型考察每日ST与全因死亡率之间的剂量效应关系。

基于19项研究中超过100万名参与者的汇总数据,结果表明,每日ST与全因死亡率之间存在对数线性剂量效应关系。总体来说,在久坐行为上花费较多时间与死亡风险增加相关。然而,测量ST的方法减弱了每日ST和死亡风险之间的相关性(p<0.05)。自我报告ST研究中的每日ST的临界点为7 h/天,而基于设备的ST研究为9 h/天。

作者认为,较多的每日ST与成人全因死亡风险增加以对数线性相关。由于使用基于设备测量的研究数量有限,因此结果表明,鼓励成人减少久坐行为是合理的,每天少于9小时对全因死亡率是重要的。

本meta回归分析基于19项设计良好的前瞻性队列研究的超过100万参与者的汇总数据,显示成人每日ST与全因死亡率(即HR)之间显著的对数线性相关性。总体而言,久坐行为时间较长与死亡风险增加前瞻性相关。有趣的是,ST的测量方法在调节每日ST对随后死亡风险的影响方面发挥作用。主观测量研究中每日ST的持续时间临界值为超过7 h。相比之下,基于设备的测量的临界点接近9 h。

本meta分析研究基于19项前瞻性队列研究(12项自我报告vs 7项基于设备的研究),发现成人每日ST的最佳量应少于7.5 h。这与一项既往队列研究的meta分析(5个自我报告vs 1项基于设备的研究)接近。

原始出处:

Ku PW, Steptoe A, Liao Y, et.al. A cut-off of daily sedentary time and all-cause mortality in adults: a meta-regression analysis involving more than 1 million participants. BMC Med. 2018 May 25;16(1):74. doi: 10.1186/s12916-018-1062-2.

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    2018-07-16 1e0f8808m18(暂无匿称)

    生命在于运动.久坐不利健康.

    0

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    2018-07-16 wzb521zf

    一起学习学习

    0

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    2018-07-16 明月清辉

    谢谢分享.学习了

    0