Neurology:下颌下腺穿刺活检可评估帕金森病

2014-02-13 高晓方 译 医学论坛网

美国一项研究表明,在帕金森病患者中通过下颌下腺穿刺活检评估Lewy型α-突触蛋白病(LTS)具有可行性。论文于2月5日在线发表于《神经病学》(Neurology)。 此项研究共纳入15例病史≥5年的帕金森病患者,并在门诊条件下实施下颌下腺经皮穿刺活检(18G或16G)。通过下唇小切口切除小唾液腺。利用福尔马林固定组织,对石蜡切片行磷酸化α-突触蛋白免疫组化染色,并对LTS征象进行评估。 结果显

美国一项研究表明,在帕金森病患者中通过下颌下腺穿刺活检评估Lewy型α-突触蛋白病(LTS)具有可行性。论文于2月5日在线发表于《神经病学》(Neurology)。

此项研究共纳入15例病史≥5年的帕金森病患者,并在门诊条件下实施下颌下腺经皮穿刺活检(18G或16G)。通过下唇小切口切除小唾液腺。利用福尔马林固定组织,对石蜡切片行磷酸化α-突触蛋白免疫组化染色,并对LTS征象进行评估。

结果显示,帕金森病患者平均年龄为68.7岁,平均病程为11.8年。12例穿刺活检具有可评估的镜下下颌下腺组织,其中9例(75%)具有LTS。15例小唾液腺活检组织中仅有1例(6.7%)为LTS阳性。5例患者出现不良事件,均较轻微并为一过性。

原始出处:

Adler CH, Dugger BN, Hinni ML, Lott DG, Driver-Dunckley E, Hidalgo J, Henry-Watson J, Serrano G, Sue LI, Nagel T, Duffy A, Shill HA, Akiyama H, Walker DG, Beach TG.Submandibular gland needle biopsy for the diagnosis of Parkinson disease.Neurology. 2014 Feb 5.

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    2014-11-07 yinhl1978
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    2014-07-10 xlysu
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    2014-05-20 iwithyou

    需要大样本实验来做支撑

    0

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    2014-02-15 smlt2008
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    2014-02-15 rgjl