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Int J Antimicrob Agents:P10软膏可根除皮肤表面耐甲氧西林金黄色葡萄球菌

2019-07-31 不详 网络

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皮肤细菌定植/感染是慢性伤口和过敏/炎性皮肤病患者发病的常见原因。该研究旨在开发一种从人体皮肤中根除耐甲氧西林金黄色葡萄球菌（MRSA）（进一步称为MRSA）的新方法。为了实现这一点，研究人员比较了新型LL-37衍生肽P10在四种软膏中的稳定性和抗菌活性。结果表明，在4℃环境中P10可在羟丙甲纤维素凝胶和含Softisan的乳膏中保持化学稳定性和抗菌效果长达16个月，但是在Cetomacrogol

皮肤细菌定植/感染是慢性伤口和过敏/炎性皮肤病患者发病的常见原因。该研究旨在开发一种从人体皮肤中根除耐甲氧西林金黄色葡萄球菌（MRSA）（进一步称为MRSA）的新方法。为了实现这一点，研究人员比较了新型LL-37衍生肽P10在四种软膏中的稳定性和抗菌活性。

结果表明，在4℃环境中P10可在羟丙甲纤维素凝胶和含Softisan的乳膏中保持化学稳定性和抗菌效果长达16个月，但是在Cetomacrogol（有或没有凡士林）中却非如此。羟丙基甲基纤维素凝胶中P10对莱顿人表皮模型（LEM）的MRSA计数的减少大于在Cetomacrogol或PBS中的肽的MRSA计数。无论使用何种软膏，P10都不会对LEM产生不良影响，而含有凡士林和Softisan霜的Cetomacrogol，但不是羟丙甲纤维素凝胶和Cetomacrogol乳膏，会破坏MRSA定植的LEM。考虑到这一点，羟丙基甲基纤维素凝胶中的P10剂量依赖性地减少MRSA定植于表皮的角质层以及该细菌菌株在LEM上的生物膜。此外，P10剂量依赖性地减少离体人皮肤上的MRSA计数，羟丙基甲基纤维素凝胶中的P10比Cetomacrogol和Softisan霜更有效。

综上所述，该研究结果表面，羟丙基甲基纤维素凝胶中的P10一起是从人体皮肤中根除MRSA的有力候选者。

原始出处：

Nibbering PH, Göblyös A, et al., Eradication of methicillin resistant S. aureus from human skin by the novel LL-37-derived peptide P10 in four pharmaceutical ointments. Int J Antimicrob Agents. 2019 Jul 26. pii: S0924-8579(19)30194-3. doi: 10.1016/j.ijantimicag.2019.07.014.

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    2019-09-25 grace5700

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    2019-10-20 jiafufeng@yaho

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    2020-03-25 xjy02

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    2020-01-28 风铃830

    #根除#

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1779522, encodeId=7fb31e7952228, content=<a href='/topic/show?id=481a2094a9' target=_blank style='color:#2F92EE;'>#Agent#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2094, encryptionId=481a2094a9, topicName=Agent)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b05b180, createdName=grace5700, createdTime=Wed Sep 25 12:55:00 CST 2019, time=2019-09-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1857822, encodeId=880a185e82298, content=<a href='/topic/show?id=3f48525849' target=_blank style='color:#2F92EE;'>#CRO#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5258, encryptionId=3f48525849, topicName=CRO)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c30265, createdName=jiafufeng@yaho, createdTime=Sun Oct 20 23:55:00 CST 2019, time=2019-10-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2084543, encodeId=b963208454373, content=<a href='/topic/show?id=61f411e013b' target=_blank style='color:#2F92EE;'>#Micro#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11701, encryptionId=61f411e013b, topicName=Micro)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d59291, createdName=xjy02, createdTime=Wed Mar 25 14:55:00 CST 2020, time=2020-03-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1683691, encodeId=885d1683691af, content=<a href='/topic/show?id=c2fc6228167' target=_blank style='color:#2F92EE;'>#根除#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=62281, encryptionId=c2fc6228167, topicName=根除)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=07d627990740, createdName=风铃830, createdTime=Tue Jan 28 20:55:00 CST 2020, time=2020-01-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1779582, encodeId=25d11e7958296, content=<a href='/topic/show?id=0473209562' target=_blank style='color:#2F92EE;'>#agents#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2095, encryptionId=0473209562, topicName=agents)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1072181, createdName=wjywjy, createdTime=Wed May 06 12:55:00 CST 2020, time=2020-05-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1305048, encodeId=34fc1305048f3, content=<a href='/topic/show?id=4b8896242d4' target=_blank style='color:#2F92EE;'>#金黄色葡萄球菌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=96242, encryptionId=4b8896242d4, topicName=金黄色葡萄球菌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2c25323, createdName=jambiya, createdTime=Fri Aug 02 04:55:00 CST 2019, time=2019-08-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1596918, encodeId=ed0b159691898, content=<a href='/topic/show?id=a3e68823477' target=_blank style='color:#2F92EE;'>#葡萄球菌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=88234, encryptionId=a3e68823477, topicName=葡萄球菌)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=11e618440395, createdName=手留余香, createdTime=Fri Aug 02 04:55:00 CST 2019, time=2019-08-02, status=1, ipAttribution=)]
    2020-05-06 wjywjy

    #agents#

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1779522, encodeId=7fb31e7952228, content=<a href='/topic/show?id=481a2094a9' target=_blank style='color:#2F92EE;'>#Agent#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2094, encryptionId=481a2094a9, topicName=Agent)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b05b180, createdName=grace5700, createdTime=Wed Sep 25 12:55:00 CST 2019, time=2019-09-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1857822, encodeId=880a185e82298, content=<a href='/topic/show?id=3f48525849' target=_blank style='color:#2F92EE;'>#CRO#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5258, encryptionId=3f48525849, topicName=CRO)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c30265, createdName=jiafufeng@yaho, createdTime=Sun Oct 20 23:55:00 CST 2019, time=2019-10-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2084543, encodeId=b963208454373, content=<a href='/topic/show?id=61f411e013b' target=_blank style='color:#2F92EE;'>#Micro#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11701, encryptionId=61f411e013b, topicName=Micro)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d59291, createdName=xjy02, createdTime=Wed Mar 25 14:55:00 CST 2020, time=2020-03-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1683691, encodeId=885d1683691af, content=<a href='/topic/show?id=c2fc6228167' target=_blank style='color:#2F92EE;'>#根除#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=62281, encryptionId=c2fc6228167, topicName=根除)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=07d627990740, createdName=风铃830, createdTime=Tue Jan 28 20:55:00 CST 2020, time=2020-01-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1779582, encodeId=25d11e7958296, content=<a href='/topic/show?id=0473209562' target=_blank style='color:#2F92EE;'>#agents#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2095, encryptionId=0473209562, topicName=agents)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1072181, createdName=wjywjy, createdTime=Wed May 06 12:55:00 CST 2020, time=2020-05-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1305048, encodeId=34fc1305048f3, content=<a href='/topic/show?id=4b8896242d4' target=_blank style='color:#2F92EE;'>#金黄色葡萄球菌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=96242, encryptionId=4b8896242d4, topicName=金黄色葡萄球菌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2c25323, createdName=jambiya, createdTime=Fri Aug 02 04:55:00 CST 2019, time=2019-08-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1596918, encodeId=ed0b159691898, content=<a href='/topic/show?id=a3e68823477' target=_blank style='color:#2F92EE;'>#葡萄球菌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=88234, encryptionId=a3e68823477, topicName=葡萄球菌)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=11e618440395, createdName=手留余香, createdTime=Fri Aug 02 04:55:00 CST 2019, time=2019-08-02, status=1, ipAttribution=)]
    2019-08-02 jambiya

    #金黄色葡萄球菌#

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=1779522, encodeId=7fb31e7952228, content=<a href='/topic/show?id=481a2094a9' target=_blank style='color:#2F92EE;'>#Agent#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2094, encryptionId=481a2094a9, topicName=Agent)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b05b180, createdName=grace5700, createdTime=Wed Sep 25 12:55:00 CST 2019, time=2019-09-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1857822, encodeId=880a185e82298, content=<a href='/topic/show?id=3f48525849' target=_blank style='color:#2F92EE;'>#CRO#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5258, encryptionId=3f48525849, topicName=CRO)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c30265, createdName=jiafufeng@yaho, createdTime=Sun Oct 20 23:55:00 CST 2019, time=2019-10-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2084543, encodeId=b963208454373, content=<a href='/topic/show?id=61f411e013b' target=_blank style='color:#2F92EE;'>#Micro#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11701, encryptionId=61f411e013b, topicName=Micro)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d59291, createdName=xjy02, createdTime=Wed Mar 25 14:55:00 CST 2020, time=2020-03-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1683691, encodeId=885d1683691af, content=<a href='/topic/show?id=c2fc6228167' target=_blank style='color:#2F92EE;'>#根除#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=62281, encryptionId=c2fc6228167, topicName=根除)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=07d627990740, createdName=风铃830, createdTime=Tue Jan 28 20:55:00 CST 2020, time=2020-01-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1779582, encodeId=25d11e7958296, content=<a href='/topic/show?id=0473209562' target=_blank style='color:#2F92EE;'>#agents#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2095, encryptionId=0473209562, topicName=agents)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=1072181, createdName=wjywjy, createdTime=Wed May 06 12:55:00 CST 2020, time=2020-05-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1305048, encodeId=34fc1305048f3, content=<a href='/topic/show?id=4b8896242d4' target=_blank style='color:#2F92EE;'>#金黄色葡萄球菌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=96242, encryptionId=4b8896242d4, topicName=金黄色葡萄球菌)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2c25323, createdName=jambiya, createdTime=Fri Aug 02 04:55:00 CST 2019, time=2019-08-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1596918, encodeId=ed0b159691898, content=<a href='/topic/show?id=a3e68823477' target=_blank style='color:#2F92EE;'>#葡萄球菌#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=88234, encryptionId=a3e68823477, topicName=葡萄球菌)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=11e618440395, createdName=手留余香, createdTime=Fri Aug 02 04:55:00 CST 2019, time=2019-08-02, status=1, ipAttribution=)]
    2019-08-02 手留余香

    #葡萄球菌#

    0