Am J Clin Nutr:不使用碘盐,儿童生长可能出现问题

2016-09-13 Mechront 译 MedSci原创

对于儿童,碘在体细胞生长障碍方面具有十分重要的生物作用;不过两者之间的关系至今仍没有得到大规模的研究。因此我们对不同国家进行了调查,评估不使用碘盐对儿童生长是否影响。 数据来自89个全国性具有代表性的样本,在1994-2012年进行重复的横断面、人口统计学资料具有可比性的健康调查;涉及46个低收入和中收入国家。我们对0-59个月儿童进行了分析,评估与生长迟缓(矮;年龄相对应的身高很低)、 体

对于儿童,碘在体细胞生长障碍方面具有十分重要的生物作用;不过两者之间的关系至今仍没有得到大规模的研究。因此我们对不同国家进行了调查,评估不使用碘盐对儿童生长是否影响。

数据来自89个全国性具有代表性的样本,在1994-2012年进行重复的横断面、人口统计学资料具有可比性的健康调查;涉及46个低收入和中收入国家。我们对0-59个月儿童进行了分析,评估与生长迟缓(矮;年龄相对应的身高很低)、 体重不足(年龄相对应的体重很低)、消瘦(按身高计算的相对体重很低)相关的因素。我们对390328例儿童进行了生长缓慢因素分析,对397080例儿童进行了体重不足因素分析,对384163例儿童进行了消瘦分析,还对187744例儿童进行了低出生体重分析。所有分析均校正了个体、母体、家庭混杂因素,以及初步抽样单位的固定效应也进行了校正。

充分校正后的分析显示,不使用碘盐与生长迟缓风险增加3%有关(95% CI of ORs: 1.00, 1.06; P = 0.04)、与体重不足风险增加5%有关(95% CI: 1.02, 1.09; P < 0.01)、与低出生体重风险增加9%有关(95% CI: 1.02, 1.17; P = 0.01)。不过当将印度标本排除在外后,不使用碘盐仅与低出生体重风险的增加有关(P = 0.05)。

虽然本项分析并没有确定的因果关系,但研究结果却表明了不使用碘盐对儿童成长的危害;并且如果碘和儿童生长之间具有因果关系的话,那么母体怀孕期间的宫内环境就十分重要了。

原始出处:

Marion Krämer.et al.Association between household unavailability of iodized salt and child growth: evidence from 89 demographic and health surveys.Am J Clin Nutr ajcn124719; First published online September 7, 2016.

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