JACC:左室功能障碍者相对室壁厚度越薄,发生室性心律失常的风险越大

2016-01-19 崔倩 译 MedSci原创

相对室壁厚度(RWT),定义为2倍后壁厚度除以左心室(LV)舒张末期内径,可能是LV功能障碍患者不良事件的的一个标志。这项研究的目的是调查参加了MADIT-CRT(多中心自动除颤器植入试验心脏再同步治疗)研究的患者RWT和室性心律失常(VA)的风险之间的关系。该研究人群包括1260例轻度心脏衰竭和左束支传导阻滞的患者。在一个多变量模型中,与常用的超声心动图的变量相比,RWT是估算VAs风险的最强大

相对室壁厚度(RWT),定义为2倍后壁厚度除以左心室(LV)舒张末期内径,可能是左室功能障碍患者不良事件的一个标志。

这项研究的目的是调查参加了MADIT-CRT(多中心自动除颤器植入试验心脏再同步治疗)研究的患者RWT和室性心律失常(VA)的风险之间的关系。

该研究人群包括1260例轻度心脏衰竭和左束支传导阻滞的患者。

在一个多变量模型中,与常用的超声心动图的变量相比,RWT是估算VA风险的最强大的超声心动图指标。与较高RWT值的患者相比,低RWT(<0.24)的患者,有83%(P<0.001)增加了VA风险,68%(P<0.001)增加了VA或VA/死亡风险。RWT每下降0.01个单位,VA和VA/死亡风险分别增加了12%(P<0.001)和10%(P<0.001)。在12个月时,与使用植入式心脏复律除颤器相比(4.6±6.8% vs 1.5±2.7%;P<0.001),使用除颤器(CRT-D,CRT与植入式心脏复律除颤器)进行心脏再同步治疗使得RWT大大增加,CRT-D患者的RWT每增加10%,随后的VA和VA/死亡风险分别减少34%(P =0.027)和36%(p=0.009)。

在轻度心脏衰竭和左束支传导阻滞患者中,降低RWT增加了VA和VA相关死亡的风险。CRT-D治疗可增加RWT,从而减少VA和VA/死亡风险。

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    2016-09-20 hbwxf
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