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Sci Transl Med：科学家发现提高人造血干细胞和前体细胞的移植能力的方法！

2018-01-05 MedSci MedSci原创

TNFα移植效率炎症信号
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本研究表明供者免疫细胞来源的炎性信号能直接影响移植的HSC的命运，并且研究结果为临床提高造血干细胞移植的植入效率相关治疗策略提供理论基础。

异基因造血干细胞移植是治疗血液疾病的有效手段，但是70%的患者不能寻找到与之相匹配的供者。目前已经充分的认识到宿主状态以及供者细胞组成影响造血干细胞移植的效果。移植后信号环境对供者造血干细胞的命运的特殊作用目前并没有明确的研究。

为了模拟临床造血干细胞移植，科学家为NOD/SCID/IL-2Rgc-null（NSG）小鼠输入了不同剂量和不同组成的人脐带血细胞。令人意外的是，高剂量脐带血细胞输注与造血干/前体细胞的植入效果成负相关。供者细胞来源的炎症信号增加导致了这个结果。

供者T细胞来源的肿瘤杀伤因子α（TNFα）特异的直接损伤移植的HSC和前体细胞的存活和分裂。在体内中和供体T细胞来源的TNFα能够在增加短期干/祖细胞（short-term stem and progenitor cell）的植入，加速造血系统的重建，并且改变供者免疫细胞的组成。TNFα在移植的细胞上的直接作用与其能够阻断IL-6的作用从而间接减轻移植物抗宿主病没有关系。本研究表明供者免疫细胞来源的炎性信号能直接影响HSC的命运，并且研究结果为临床提高造血干细胞移植的植入效率相关治疗策略提供理论基础。


原文出处：Wang W， Fujii H， Kim H J， et al. Enhanced human hematopoietic stem and progenitor cell engraftment by blocking donor T cell–mediated TNFα signaling[J]. Science translational medicine， 2017， 9(421)： eaag3214.DOI： 10.1126/scitranslmed.aag3214

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    2018-01-28 ms3025846204744509

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    2018-05-02 bsmagic9140

    #TRA#

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    2018-10-04 旅苦化文_208

    #科学家发现#

    0

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    2018-01-07 zhouqu_8

    #造血干细胞#

    0

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    2018-01-07 zhouqu_8

    #体细胞#

    0

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    2018-01-07 俅侠

    #造血#

    0

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    2018-01-07 ms3994565386320060

    #Med#

    0

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