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Metabolism：循环ApoJ与胰岛素抵抗密切相关！

2017-10-21 xing.T MedSci原创

ApoJ胰岛素抵抗T2DM
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血清ApoJ水与胰岛素抵抗程度平密切相关，无论肥胖，并且只有在采用罗格列酮治疗的2型糖尿病患者中随着胰岛素抵抗的改善而有所降低。循环中ApoJ是否可以作为胰岛素抵抗的标记和/或促进因子还需要进一步的研究来探索。

胰岛素抵抗是2型糖尿病的主要危险因素，载脂蛋白J（ApoJ）参与了心血管疾病和老年痴呆症等疾病的病理生理状态。然而，ApoJ在调节血糖平衡中的作用仍不清楚。近日，代谢性疾病领域权威杂志Metabolism-Clinical and Experimental上发表了一篇研究文章，研究人员的目的是明确血清中ApoJ的水平是否与人类胰岛素抵抗相关，并且通过干预改变ApoJ的水平是否会提高胰岛素的敏感性。

研究人员评估了非糖尿病（ND）和2型糖尿病（T2DM）受试者空腹血清中ApoJ水平和胰岛素抵抗的状态。在高胰岛素/葡萄糖钳夹试验中罗格列酮或二甲双胍治疗对血清ApoJ水平和葡萄糖利用率（GDR）影响是在一个单独的T2DM受试者的队列中进行评估的。总ApoJ蛋白或与HDL和LDL相关的组分采用免疫印迹和ELISA进行测定。

在T2D受试者中，空腹血清ApoJ水平明显升高（ND vs. T2D；100±8.3 vs. 150.6±8.5AU，P＜0.0001）。循环中ApoJ水平与空腹血糖、空腹胰岛素、胰岛素抵抗指数、BMI密切相关。ApoJ水平均与HOMA-IR显著并独立相关，即使调整了年龄、性别和体重指数后。T2D受试者采用罗格列酮治疗会导致血清ApoJ水平降低（治疗前 vs. 治疗后；100±13.9 vs. 77±15.2AU，P=0.015），而二甲双胍对ApoJ水平没有影响。在治疗过程中ApoJ水平的变化与GDR的变化呈负相关化。有趣的是，ApoJ在低密度脂蛋白中的含量分数与HOMA-IR呈负相关。

血清ApoJ水与胰岛素抵抗程度平密切相关，无论肥胖，并且只有在采用罗格列酮治疗的2型糖尿病患者中随着胰岛素抵抗的改善而有所降低。循环中ApoJ是否可以作为胰岛素抵抗的标记和/或促进因子还需要进一步的研究来探索。

原始出处：

Ji A. Seo1,et al. Circulating ApoJ is closely associated with insulin resistance in human subjects.Metabolism-Clinical and Experimental.2017. http://dx.doi.org/10.1016/j.metabol.2017.09.014

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    2018-09-12 baoya

    #胰岛#

    0

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    2018-01-13 guojianrong

    #Meta#

    0

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    2017-12-22 一闲

    #MET#

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    2017-10-23 1249859em43(暂无昵称)

    #Metabolism#

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    2017-10-23 闆锋旦

    #ABO#

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1749846, encodeId=189e1e4984664, content=<a href='/topic/show?id=be7c8385345' target=_blank style='color:#2F92EE;'>#胰岛#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=83853, encryptionId=be7c8385345, topicName=胰岛)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a7a536274692, createdName=baoya, createdTime=Wed Sep 12 18:25:00 CST 2018, time=2018-09-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1887743, encodeId=54d0188e7437b, content=<a href='/topic/show?id=d56611584ec' target=_blank style='color:#2F92EE;'>#Meta#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11584, encryptionId=d56611584ec, topicName=Meta)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d8f4110, createdName=guojianrong, createdTime=Sat Jan 13 08:25:00 CST 2018, time=2018-01-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1896168, encodeId=3116189616845, content=<a href='/topic/show?id=4a391158248' target=_blank style='color:#2F92EE;'>#MET#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11582, encryptionId=4a391158248, topicName=MET)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=18fc139, createdName=一闲, createdTime=Fri Dec 22 15:25:00 CST 2017, time=2017-12-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1577176, encodeId=034015e7176b0, content=<a href='/topic/show?id=d86d1159e36' target=_blank style='color:#2F92EE;'>#Metabolism#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11597, encryptionId=d86d1159e36, topicName=Metabolism)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1a6516392333, createdName=1249859em43(暂无昵称), createdTime=Mon Oct 23 07:25:00 CST 2017, time=2017-10-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1597980, encodeId=1612159e980a6, content=<a href='/topic/show?id=6c6f1e62c5' target=_blank style='color:#2F92EE;'>#ABO#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1762, encryptionId=6c6f1e62c5, topicName=ABO)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b6c918580135, createdName=闆锋旦, createdTime=Mon Oct 23 07:25:00 CST 2017, time=2017-10-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=254916, encodeId=8db925491646, content=不错的.学习了.谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mStl88fu4NdqKgfW3nMpOkC3jXxiaW2po0PtglY5ZuVjERqKADW4HyMI8bcZXWlKgH7tEP9ULBoBzuQMibia4pr1s9rQPqLvqQJ/0, createdBy=e8c02060444, createdName=中医痴, createdTime=Sat Oct 21 19:27:52 CST 2017, time=2017-10-21, status=1, ipAttribution=)]
    2017-10-21 中医痴

    不错的.学习了.谢谢分享!

    0