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63000名患者研究使AJCC首次将ER/PR/HER2作为乳腺癌分期依据

2016-12-28 基因慧PPT 汪亮 基因慧PPT 汪亮

AJCCER/PR/HER2乳腺癌分期依据
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美国癌症联合委员会（AJCC）首次将将分子标记添加到分期标准，包括雌激素受体（ER），孕酮受体（PR）和HER2等。美国癌症联合委员会（AJCC）今天宣布，基于翔实的临床证据，美国癌症联合委员会（AJCC）把OncotypeDX?检测试剂盒纳入最近公布的第八版AJCC癌症分期手册中。根据超过63,000名患者的临床证据，更新的标准基于严格的多学科评估，将Oncotype DX选定为唯一确定乳腺癌患

美国癌症联合委员会（AJCC）首次将将分子标记添加到分期标准，包括雌激素受体（ER），孕酮受体（PR）和HER2等。


美国癌症联合委员会（AJCC）今天宣布，基于翔实的临床证据，美国癌症联合委员会（AJCC）把OncotypeDX?检测试剂盒纳入最近公布的第八版AJCC癌症分期手册中。根据超过63,000名患者的临床证据，更新的标准基于严格的多学科评估，将Oncotype DX选定为唯一确定乳腺癌患者的正式分期具有I级证据的多基因检测。

Steven Shak, M.D. Co-Founder, Chief Scientific Officer，Genomic Health

Genomic Health首席科学官Steven Shak博士说：“AJCC首次增加了分子标记以补充该疾病的传统解剖特征，将癌症诊断和护理转变为真正的个体化医疗。 ”通过Oncotype DX 的多个前瞻性研究，我们相信这一突破性的里程碑将帮助临床医生提高能力，更好地服务于患者。

从2018年1月起，AJCC将Oncotype DX Breast Recurrence Score?（Oncology DX乳腺癌复发评分）添加到新的预后阶段分期，将ER，PR和HER2等分子标记物状态，联合淋巴结状态，肿瘤大小，肿瘤等级作为乳腺癌分期。对于淋巴结阴性或淋巴结微转移的患者，低的Oncotype DX复发评分（RS <11）将患者分为最有利的预后期，与肿瘤分级或肿瘤大小无关（高达5厘米）。

作为实施过程的一部分，所有AJCC合作伙伴，包括美国病理学家学院（CAP）和国家综合癌症网络（NCCN），将制定和更新协议和工具，以促进在2018年成功采用所需的新分期系统规则。第八版AJCC癌症分期手册的电子版预计将于2017年第一季度上市。

如AJCC出版物中所述，“专家组确定，根据目前最好的证据，合并多基因分子谱以将Oncotype DX Breast Recurrence Score?（Oncology DX乳腺癌复发评分）纳入TAILORx研究中的Arm A定义的小组分期，这些患者应根据AJCC预后阶段组进行分期，Oncotype DX检查的结果由I级证据（大规模前瞻性临床试验数据）支持。

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  1. [GetPortalCommentsPageByObjectIdResponse(id=1907906, encodeId=6b95190e9069d, content=<a href='/topic/show?id=efbc22202c' target=_blank style='color:#2F92EE;'>#AJCC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2220, encryptionId=efbc22202c, topicName=AJCC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=74c2229, createdName=tcm99hq, createdTime=Fri Apr 14 03:40:00 CST 2017, time=2017-04-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2029814, encodeId=d50d20298149e, content=<a href='/topic/show?id=93346909db' target=_blank style='color:#2F92EE;'>#ER/PR/HER2#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=15, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6909, encryptionId=93346909db, topicName=ER/PR/HER2)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/71tKRib0PibveVjnEa7tPLMaCzoKicFlKSEOzRTGf4wNvDV54kJyNx1ott1D5Xp5gRu7IwUia77oN0YFdffvQMu6Ug/132, createdBy=9e302500146, createdName=ms49895894946433513521, createdTime=Thu Apr 13 09:40:00 CST 2017, time=2017-04-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=170595, encodeId=07791e059596, content=学习啦，谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b1e374381, createdName=逃家小兔, createdTime=Sun Jan 15 21:54:49 CST 2017, time=2017-01-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=167284, encodeId=44eb16e28418, content=很好，不错，以后会多学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzUn81b5CF5ibVPib8jWI92iciaxmqGHlwruOnK4SVZykd4iahqo1hicklIibyZoxm55X7EM8BW9eX1h1hQ2/0, createdBy=8aa81937526, createdName=李东泽, createdTime=Sun Jan 01 19:05:03 CST 2017, time=2017-01-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=167271, encodeId=d74f16e27137, content=乳腺癌分期即将迎来巨变, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2019/11/19/9bc45f4ae162bd654210831f4e7ea3d0.jpg, createdBy=bbf11609910, createdName=杨帆7792, createdTime=Sun Jan 01 16:07:59 CST 2017, time=2017-01-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=166583, encodeId=f195166583b4, content=哪个公司的这是, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=90541990513, createdName=Shirley_dai, createdTime=Thu Dec 29 13:14:56 CST 2016, time=2016-12-29, status=1, ipAttribution=)]
    2017-04-14 tcm99hq

    #AJCC#

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=1907906, encodeId=6b95190e9069d, content=<a href='/topic/show?id=efbc22202c' target=_blank style='color:#2F92EE;'>#AJCC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2220, encryptionId=efbc22202c, topicName=AJCC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=74c2229, createdName=tcm99hq, createdTime=Fri Apr 14 03:40:00 CST 2017, time=2017-04-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2029814, encodeId=d50d20298149e, content=<a href='/topic/show?id=93346909db' target=_blank style='color:#2F92EE;'>#ER/PR/HER2#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=15, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6909, encryptionId=93346909db, topicName=ER/PR/HER2)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/71tKRib0PibveVjnEa7tPLMaCzoKicFlKSEOzRTGf4wNvDV54kJyNx1ott1D5Xp5gRu7IwUia77oN0YFdffvQMu6Ug/132, createdBy=9e302500146, createdName=ms49895894946433513521, createdTime=Thu Apr 13 09:40:00 CST 2017, time=2017-04-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=170595, encodeId=07791e059596, content=学习啦，谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b1e374381, createdName=逃家小兔, createdTime=Sun Jan 15 21:54:49 CST 2017, time=2017-01-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=167284, encodeId=44eb16e28418, content=很好，不错，以后会多学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzUn81b5CF5ibVPib8jWI92iciaxmqGHlwruOnK4SVZykd4iahqo1hicklIibyZoxm55X7EM8BW9eX1h1hQ2/0, createdBy=8aa81937526, createdName=李东泽, createdTime=Sun Jan 01 19:05:03 CST 2017, time=2017-01-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=167271, encodeId=d74f16e27137, content=乳腺癌分期即将迎来巨变, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2019/11/19/9bc45f4ae162bd654210831f4e7ea3d0.jpg, createdBy=bbf11609910, createdName=杨帆7792, createdTime=Sun Jan 01 16:07:59 CST 2017, time=2017-01-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=166583, encodeId=f195166583b4, content=哪个公司的这是, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=90541990513, createdName=Shirley_dai, createdTime=Thu Dec 29 13:14:56 CST 2016, time=2016-12-29, status=1, ipAttribution=)]
    2017-04-13 ms49895894946433513521

    #ER/PR/HER2#

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=1907906, encodeId=6b95190e9069d, content=<a href='/topic/show?id=efbc22202c' target=_blank style='color:#2F92EE;'>#AJCC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2220, encryptionId=efbc22202c, topicName=AJCC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=74c2229, createdName=tcm99hq, createdTime=Fri Apr 14 03:40:00 CST 2017, time=2017-04-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2029814, encodeId=d50d20298149e, content=<a href='/topic/show?id=93346909db' target=_blank style='color:#2F92EE;'>#ER/PR/HER2#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=15, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6909, encryptionId=93346909db, topicName=ER/PR/HER2)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/71tKRib0PibveVjnEa7tPLMaCzoKicFlKSEOzRTGf4wNvDV54kJyNx1ott1D5Xp5gRu7IwUia77oN0YFdffvQMu6Ug/132, createdBy=9e302500146, createdName=ms49895894946433513521, createdTime=Thu Apr 13 09:40:00 CST 2017, time=2017-04-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=170595, encodeId=07791e059596, content=学习啦，谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b1e374381, createdName=逃家小兔, createdTime=Sun Jan 15 21:54:49 CST 2017, time=2017-01-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=167284, encodeId=44eb16e28418, content=很好，不错，以后会多学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzUn81b5CF5ibVPib8jWI92iciaxmqGHlwruOnK4SVZykd4iahqo1hicklIibyZoxm55X7EM8BW9eX1h1hQ2/0, createdBy=8aa81937526, createdName=李东泽, createdTime=Sun Jan 01 19:05:03 CST 2017, time=2017-01-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=167271, encodeId=d74f16e27137, content=乳腺癌分期即将迎来巨变, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2019/11/19/9bc45f4ae162bd654210831f4e7ea3d0.jpg, createdBy=bbf11609910, createdName=杨帆7792, createdTime=Sun Jan 01 16:07:59 CST 2017, time=2017-01-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=166583, encodeId=f195166583b4, content=哪个公司的这是, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=90541990513, createdName=Shirley_dai, createdTime=Thu Dec 29 13:14:56 CST 2016, time=2016-12-29, status=1, ipAttribution=)]
    2017-01-15 逃家小兔

    学习啦，谢谢分享

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=1907906, encodeId=6b95190e9069d, content=<a href='/topic/show?id=efbc22202c' target=_blank style='color:#2F92EE;'>#AJCC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2220, encryptionId=efbc22202c, topicName=AJCC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=74c2229, createdName=tcm99hq, createdTime=Fri Apr 14 03:40:00 CST 2017, time=2017-04-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2029814, encodeId=d50d20298149e, content=<a href='/topic/show?id=93346909db' target=_blank style='color:#2F92EE;'>#ER/PR/HER2#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=15, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6909, encryptionId=93346909db, topicName=ER/PR/HER2)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/71tKRib0PibveVjnEa7tPLMaCzoKicFlKSEOzRTGf4wNvDV54kJyNx1ott1D5Xp5gRu7IwUia77oN0YFdffvQMu6Ug/132, createdBy=9e302500146, createdName=ms49895894946433513521, createdTime=Thu Apr 13 09:40:00 CST 2017, time=2017-04-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=170595, encodeId=07791e059596, content=学习啦，谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b1e374381, createdName=逃家小兔, createdTime=Sun Jan 15 21:54:49 CST 2017, time=2017-01-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=167284, encodeId=44eb16e28418, content=很好，不错，以后会多学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzUn81b5CF5ibVPib8jWI92iciaxmqGHlwruOnK4SVZykd4iahqo1hicklIibyZoxm55X7EM8BW9eX1h1hQ2/0, createdBy=8aa81937526, createdName=李东泽, createdTime=Sun Jan 01 19:05:03 CST 2017, time=2017-01-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=167271, encodeId=d74f16e27137, content=乳腺癌分期即将迎来巨变, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2019/11/19/9bc45f4ae162bd654210831f4e7ea3d0.jpg, createdBy=bbf11609910, createdName=杨帆7792, createdTime=Sun Jan 01 16:07:59 CST 2017, time=2017-01-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=166583, encodeId=f195166583b4, content=哪个公司的这是, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=90541990513, createdName=Shirley_dai, createdTime=Thu Dec 29 13:14:56 CST 2016, time=2016-12-29, status=1, ipAttribution=)]
    2017-01-01 李东泽

    很好，不错，以后会多学习

    0

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    2017-01-01 杨帆7792

    乳腺癌分期即将迎来巨变

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1907906, encodeId=6b95190e9069d, content=<a href='/topic/show?id=efbc22202c' target=_blank style='color:#2F92EE;'>#AJCC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2220, encryptionId=efbc22202c, topicName=AJCC)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=74c2229, createdName=tcm99hq, createdTime=Fri Apr 14 03:40:00 CST 2017, time=2017-04-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2029814, encodeId=d50d20298149e, content=<a href='/topic/show?id=93346909db' target=_blank style='color:#2F92EE;'>#ER/PR/HER2#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=15, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6909, encryptionId=93346909db, topicName=ER/PR/HER2)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/71tKRib0PibveVjnEa7tPLMaCzoKicFlKSEOzRTGf4wNvDV54kJyNx1ott1D5Xp5gRu7IwUia77oN0YFdffvQMu6Ug/132, createdBy=9e302500146, createdName=ms49895894946433513521, createdTime=Thu Apr 13 09:40:00 CST 2017, time=2017-04-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=170595, encodeId=07791e059596, content=学习啦，谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b1e374381, createdName=逃家小兔, createdTime=Sun Jan 15 21:54:49 CST 2017, time=2017-01-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=167284, encodeId=44eb16e28418, content=很好，不错，以后会多学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzUn81b5CF5ibVPib8jWI92iciaxmqGHlwruOnK4SVZykd4iahqo1hicklIibyZoxm55X7EM8BW9eX1h1hQ2/0, createdBy=8aa81937526, createdName=李东泽, createdTime=Sun Jan 01 19:05:03 CST 2017, time=2017-01-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=167271, encodeId=d74f16e27137, content=乳腺癌分期即将迎来巨变, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2019/11/19/9bc45f4ae162bd654210831f4e7ea3d0.jpg, createdBy=bbf11609910, createdName=杨帆7792, createdTime=Sun Jan 01 16:07:59 CST 2017, time=2017-01-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=166583, encodeId=f195166583b4, content=哪个公司的这是, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=90541990513, createdName=Shirley_dai, createdTime=Thu Dec 29 13:14:56 CST 2016, time=2016-12-29, status=1, ipAttribution=)]
    2016-12-29 Shirley_dai

    哪个公司的这是

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