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Laryngoscope：3D打印的聚己内酯/β-磷酸三钙下颌假体

2019-03-14 不详 网络

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在这项研究中，我们评估了扁桃体衍生的间充质干细胞（TMSC）-移植的聚己内酯/β-磷酸三钙假体对兔下颌骨成骨的有效性。在18只兔的下颌骨制备10×8mm的骨缺损。两只兔子没有接受植入物;用支架对照（SC）（SC组）重建4个;用浸泡在外周血（PB）（PB组）中的支架重建4个;用TMSC移植的支架（TMSC组）重建4个;用分化的骨细胞移植支架（DOC）（DOC组）重建4个。手术后12周处死每只兔子，通

在这项研究中，我们评估了扁桃体衍生的间充质干细胞（TMSC）-移植的聚己内酯/β-磷酸三钙假体对兔下颌骨成骨的有效性。

在18只兔的下颌骨制备10×8mm的骨缺损。两只兔子没有接受植入物;用支架对照（SC）（SC组）重建4个;用浸泡在外周血（PB）（PB组）中的支架重建4个;用TMSC移植的支架（TMSC组）重建4个;用分化的骨细胞移植支架（DOC）（DOC组）重建4个。手术后12周处死每只兔子，通过机械测试，组织学和微型计算机断层扫描研究新骨形成的区域。

结果显示，尽管在所有组中纤维化和血管形成水平相似，但在TMSC和DOC组中观察到更多延伸和更密集的新骨质量，表明单独的双结构支架为骨附着和再生提供了良好的环境。来自SC，PB，TMSC和DOC组的代表性支架的骨体积分别为总体积的43.12,48.35,53.10和57.44％。

总之，该研究结果表明，支架的设计导致有效的成骨，并且TMSC显示成骨效力，表明它们的组合可以实现有效的骨再生。

原始出处：

Park JH, Jung SY, et al., A 3D-printed polycaprolactone/β-tricalcium phosphate mandibular prosthesis: A pilot animal study. Laryngoscope. 2019 Mar 12. doi: 10.1002/lary.27908.

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    2019-04-12 chenshujs

    #磷酸三钙#

    0

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    2020-02-26 feather89

    #PE#

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    2019-12-09 xlysu

    #下颌#

    0

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    2019-03-16 ms9833124466084992

    #3D#

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    2019-03-16 lanyan20020088

    #假体#

    0