Plos One:天竺葵属老鹳草提取物具有对抗艾滋病HIV-1病毒的作用

2014-02-08 新华 新华网

    德国的研究人员表示,天竺葵属植物可能是新型艾滋病(HIV)治疗方法的关键所在。天竺葵属植物老鹳草的提取物可使HIV-1型病毒失去活性,防止病毒侵入人体细胞。     据英国《每日邮报》网站1月31日报道,HIV病毒分为两种类型——HIV-1型和HIV-2型。绝大多数艾滋病患者感染的都是HIV-1型病毒。位于慕尼黑的德国

德国的研究人员表示,天竺葵属植物可能是新型艾滋病(HIV)治疗方法的关键所在。天竺葵属植物老鹳草的提取物可使HIV-1型病毒失去活性,防止病毒侵入人体细胞。


HIV病毒分为两种类型——HIV-1型和HIV-2型。绝大多数艾滋病患者感染的都是HIV-1型病毒。位于慕尼黑的德国环境卫生研究中心的研究人员说,天竺葵属植物的提取物可能成为一种新型的治疗HIV-1型艾滋病的药物EPs®7630。

研究人员发现,天竺葵植物的根部提取物含有一种可抗击HIV-1型病毒并阻止其在人体内复制的化合物。他们发现,这种提取物还能保护血液和免疫细胞免遭艾滋病病毒感染。提取物可阻止HIV病毒颗粒与人体细胞结合,从而有效防止病毒侵入细胞。

一些临床试验已经证实,天竺葵提取物对人体无害,而且在德国,使用天竺葵提取物制造草药已获得批准。

该研究团队负责人露特·布拉克-维尔纳教授说:“(天竺葵)提取物为研制第一种经科学验证的治疗HIV-1型艾滋病的植物药指明了一条希望之路。”“(该)提取物抗击HIV-1型病毒的方式与目前临床使用的所有治疗HIV-1型艾滋病的药物都不同。因此,(它们)可能是对既有的艾滋病治疗方法的重要补充。”“此外,在资源有限的情况下,(该)提取物很有可能成为一种治疗HIV-1型艾滋病的药物,因为它们容易生产,且不需要冷藏。”

“既然研究已得出结果,提取物的安全性也得到证实,下一步将是在感染HIV-1型病毒的患者身上进行测试。”

根据世界卫生组织的数据,全球艾滋病患者数量超过3500万,其中绝大多数感染的是HIV-1型病毒。

如果不接受治疗,HIV病毒会摧毁免疫系统,并引发获得性免疫缺陷综合征(艾滋病),威胁患者生命。艾滋病是全球十大致死疾病之一。

实际上,在中国国内有一种抗艾滋病的中药复方---唐草片,其中就以老鹳草作为主要原料成分。另外,国际上2000年便有论文显示,老鹳草具有抗HIV的作用。

小知识:

唐草片由老鹳草、瓜蒌皮、柴胡、香薷、黄芪、木棉花、鸡血藤、糯稻根、诃子、白花蛇舌草、马齿苋、胡黄连、全蝎等20多种名贵中药材制成,有清热解毒、活 血益气作用,可以治疗艾滋病,用于艾滋病毒感染者以及艾滋病患者(CD4淋巴细胞在100-400个/mm 3之间),有提高CD4淋巴细胞计数作用,可改善乏力、脱发、食欲减退和腹泻等症状,改善活动功能状况

原始出处:
Helfer M, Koppensteiner H, Schneider M, Rebensburg S, Forcisi S, Müller C, Schmitt-Kopplin P, Schindler M, Brack-Werner R.The Root Extract of the Medicinal Plant Pelargonium sidoides Is a Potent HIV-1 Attachment Inhibitor.PLoS One. 2014 Jan 29;9(1):e87487. 【原文下载】

Mlinaric A, Kreft S, Umek A, Strukelj B.Screening of selected plant extracts for in vitro inhibitory activity on HIV-1 reverse transcriptase (HIV-1 RT).Pharmazie. 2000 Jan;55(1):75-7

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  1. [GetPortalCommentsPageByObjectIdResponse(id=2119039, encodeId=472f2119039e8, content=<a href='/topic/show?id=d2e544192ed' target=_blank style='color:#2F92EE;'>#天竺葵#</a>属植物<a href='/topic/show?id=12958028e38' target=_blank style='color:#2F92EE;'>#老鹳草#</a>的提取物可使HIV-1型病毒失去活性,防止病毒侵入人体细胞。<a href='/topic/show?id=a48786e89c1' target=_blank style='color:#2F92EE;'>#艾滋病#</a><a href='/topic/show?id=edbd88e6e7' target=_blank style='color:#2F92EE;'>#HIV#</a> 从文献来看,很多天竺葵属植物均有作用。Plants like Rheum palmatum L., Rheum officinale, Trigonostem axyphophylloides, Vatica astrotricha, Vernonia amygdalina, Hypoxias pelargonium, Sidoides hemerocallidea and Sutherlandia frutescens etc. have high efficacy to cure HIV. 这里包括<a href='/topic/show?id=2c5110564699' target=_blank style='color:#2F92EE;'>#杏仁斑鸠菊#</a>、<a href='/topic/show?id=36aa10564e6b' target=_blank style='color:#2F92EE;'>#紫叶天竺葵#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=91, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=44192, encryptionId=d2e544192ed, topicName=天竺葵), TopicDto(id=80287, encryptionId=12958028e38, topicName=老鹳草), TopicDto(id=86789, encryptionId=a48786e89c1, topicName=艾滋病), TopicDto(id=8876, encryptionId=edbd88e6e7, topicName=HIV), TopicDto(id=105646, encryptionId=2c5110564699, topicName=杏仁斑鸠菊), TopicDto(id=105647, encryptionId=36aa10564e6b, topicName=紫叶天竺葵)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/Random/55971dc507c93968175ce7cc1e177b372a83869f.jpg, createdBy=f63e4754896, createdName=侠胆医心, createdTime=Sun Mar 12 10:16:21 CST 2023, time=2023-03-12, status=1, ipAttribution=上海), GetPortalCommentsPageByObjectIdResponse(id=1717173, encodeId=56671e17173a0, content=<a href='/topic/show?id=12958028e38' target=_blank style='color:#2F92EE;'>#老鹳草#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=80287, encryptionId=12958028e38, topicName=老鹳草)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=944632357610, createdName=qidongfanjian, createdTime=Wed Oct 22 08:49:00 CST 2014, time=2014-10-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1789569, encodeId=df0c1e8956999, content=<a href='/topic/show?id=6e4814388e2' target=_blank style='color:#2F92EE;'>#Plos one#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14388, encryptionId=6e4814388e2, topicName=Plos one)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fda6311, createdName=119337457, createdTime=Tue Oct 07 17:49:00 CST 2014, time=2014-10-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1503607, encodeId=2542150360eee, content=<a href='/topic/show?id=d2e544192ed' target=_blank style='color:#2F92EE;'>#天竺葵#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=44192, encryptionId=d2e544192ed, topicName=天竺葵)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=99a09671720, createdName=karmond, createdTime=Mon Feb 10 01:49:00 CST 2014, time=2014-02-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=7236, encodeId=3e3de236e1, content=甘肃老中医以纯中药治疗艾滋病70余例,这个报道以前被人笑死了。现在看来,为什么不能呢?, beContent=null, objectType=article, channel=null, level=null, likeNumber=183, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=hhf, createdTime=Sat Feb 08 12:01:00 CST 2014, time=2014-02-08, status=1, ipAttribution=)]
    2023-03-12 侠胆医心 来自上海

    #天竺葵#属植物#老鹳草#的提取物可使HIV-1型病毒失去活性,防止病毒侵入人体细胞。#艾滋病##HIV# 从文献来看,很多天竺葵属植物均有作用。Plants like Rheum palmatum L., Rheum officinale, Trigonostem axyphophylloides, Vatica astrotricha, Vernonia amygdalina, Hypoxias pelargonium, Sidoides hemerocallidea and Sutherlandia frutescens etc. have high efficacy to cure HIV. 这里包括#杏仁斑鸠菊##紫叶天竺葵#

    0

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  3. [GetPortalCommentsPageByObjectIdResponse(id=2119039, encodeId=472f2119039e8, content=<a href='/topic/show?id=d2e544192ed' target=_blank style='color:#2F92EE;'>#天竺葵#</a>属植物<a href='/topic/show?id=12958028e38' target=_blank style='color:#2F92EE;'>#老鹳草#</a>的提取物可使HIV-1型病毒失去活性,防止病毒侵入人体细胞。<a href='/topic/show?id=a48786e89c1' target=_blank style='color:#2F92EE;'>#艾滋病#</a><a href='/topic/show?id=edbd88e6e7' target=_blank style='color:#2F92EE;'>#HIV#</a> 从文献来看,很多天竺葵属植物均有作用。Plants like Rheum palmatum L., Rheum officinale, Trigonostem axyphophylloides, Vatica astrotricha, Vernonia amygdalina, Hypoxias pelargonium, Sidoides hemerocallidea and Sutherlandia frutescens etc. have high efficacy to cure HIV. 这里包括<a href='/topic/show?id=2c5110564699' target=_blank style='color:#2F92EE;'>#杏仁斑鸠菊#</a>、<a href='/topic/show?id=36aa10564e6b' target=_blank style='color:#2F92EE;'>#紫叶天竺葵#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=91, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=44192, encryptionId=d2e544192ed, topicName=天竺葵), TopicDto(id=80287, encryptionId=12958028e38, topicName=老鹳草), TopicDto(id=86789, encryptionId=a48786e89c1, topicName=艾滋病), TopicDto(id=8876, encryptionId=edbd88e6e7, topicName=HIV), TopicDto(id=105646, encryptionId=2c5110564699, topicName=杏仁斑鸠菊), TopicDto(id=105647, encryptionId=36aa10564e6b, topicName=紫叶天竺葵)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/Random/55971dc507c93968175ce7cc1e177b372a83869f.jpg, createdBy=f63e4754896, createdName=侠胆医心, createdTime=Sun Mar 12 10:16:21 CST 2023, time=2023-03-12, status=1, ipAttribution=上海), GetPortalCommentsPageByObjectIdResponse(id=1717173, encodeId=56671e17173a0, content=<a href='/topic/show?id=12958028e38' target=_blank style='color:#2F92EE;'>#老鹳草#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=80287, encryptionId=12958028e38, topicName=老鹳草)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=944632357610, createdName=qidongfanjian, createdTime=Wed Oct 22 08:49:00 CST 2014, time=2014-10-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1789569, encodeId=df0c1e8956999, content=<a href='/topic/show?id=6e4814388e2' target=_blank style='color:#2F92EE;'>#Plos one#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14388, encryptionId=6e4814388e2, topicName=Plos one)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fda6311, createdName=119337457, createdTime=Tue Oct 07 17:49:00 CST 2014, time=2014-10-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1503607, encodeId=2542150360eee, content=<a href='/topic/show?id=d2e544192ed' target=_blank style='color:#2F92EE;'>#天竺葵#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=44192, encryptionId=d2e544192ed, topicName=天竺葵)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=99a09671720, createdName=karmond, createdTime=Mon Feb 10 01:49:00 CST 2014, time=2014-02-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=7236, encodeId=3e3de236e1, content=甘肃老中医以纯中药治疗艾滋病70余例,这个报道以前被人笑死了。现在看来,为什么不能呢?, beContent=null, objectType=article, channel=null, level=null, likeNumber=183, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=hhf, createdTime=Sat Feb 08 12:01:00 CST 2014, time=2014-02-08, status=1, ipAttribution=)]
  4. [GetPortalCommentsPageByObjectIdResponse(id=2119039, encodeId=472f2119039e8, content=<a href='/topic/show?id=d2e544192ed' target=_blank style='color:#2F92EE;'>#天竺葵#</a>属植物<a href='/topic/show?id=12958028e38' target=_blank style='color:#2F92EE;'>#老鹳草#</a>的提取物可使HIV-1型病毒失去活性,防止病毒侵入人体细胞。<a href='/topic/show?id=a48786e89c1' target=_blank style='color:#2F92EE;'>#艾滋病#</a><a href='/topic/show?id=edbd88e6e7' target=_blank style='color:#2F92EE;'>#HIV#</a> 从文献来看,很多天竺葵属植物均有作用。Plants like Rheum palmatum L., Rheum officinale, Trigonostem axyphophylloides, Vatica astrotricha, Vernonia amygdalina, Hypoxias pelargonium, Sidoides hemerocallidea and Sutherlandia frutescens etc. have high efficacy to cure HIV. 这里包括<a href='/topic/show?id=2c5110564699' target=_blank style='color:#2F92EE;'>#杏仁斑鸠菊#</a>、<a href='/topic/show?id=36aa10564e6b' target=_blank style='color:#2F92EE;'>#紫叶天竺葵#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=91, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=44192, encryptionId=d2e544192ed, topicName=天竺葵), TopicDto(id=80287, encryptionId=12958028e38, topicName=老鹳草), TopicDto(id=86789, encryptionId=a48786e89c1, topicName=艾滋病), TopicDto(id=8876, encryptionId=edbd88e6e7, topicName=HIV), TopicDto(id=105646, encryptionId=2c5110564699, topicName=杏仁斑鸠菊), TopicDto(id=105647, encryptionId=36aa10564e6b, topicName=紫叶天竺葵)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/Random/55971dc507c93968175ce7cc1e177b372a83869f.jpg, createdBy=f63e4754896, createdName=侠胆医心, createdTime=Sun Mar 12 10:16:21 CST 2023, time=2023-03-12, status=1, ipAttribution=上海), GetPortalCommentsPageByObjectIdResponse(id=1717173, encodeId=56671e17173a0, content=<a href='/topic/show?id=12958028e38' target=_blank style='color:#2F92EE;'>#老鹳草#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=80287, encryptionId=12958028e38, topicName=老鹳草)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=944632357610, createdName=qidongfanjian, createdTime=Wed Oct 22 08:49:00 CST 2014, time=2014-10-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1789569, encodeId=df0c1e8956999, content=<a href='/topic/show?id=6e4814388e2' target=_blank style='color:#2F92EE;'>#Plos one#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14388, encryptionId=6e4814388e2, topicName=Plos one)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fda6311, createdName=119337457, createdTime=Tue Oct 07 17:49:00 CST 2014, time=2014-10-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1503607, encodeId=2542150360eee, content=<a href='/topic/show?id=d2e544192ed' target=_blank style='color:#2F92EE;'>#天竺葵#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=44192, encryptionId=d2e544192ed, topicName=天竺葵)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=99a09671720, createdName=karmond, createdTime=Mon Feb 10 01:49:00 CST 2014, time=2014-02-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=7236, encodeId=3e3de236e1, content=甘肃老中医以纯中药治疗艾滋病70余例,这个报道以前被人笑死了。现在看来,为什么不能呢?, beContent=null, objectType=article, channel=null, level=null, likeNumber=183, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=hhf, createdTime=Sat Feb 08 12:01:00 CST 2014, time=2014-02-08, status=1, ipAttribution=)]
    2014-02-10 karmond
  5. [GetPortalCommentsPageByObjectIdResponse(id=2119039, encodeId=472f2119039e8, content=<a href='/topic/show?id=d2e544192ed' target=_blank style='color:#2F92EE;'>#天竺葵#</a>属植物<a href='/topic/show?id=12958028e38' target=_blank style='color:#2F92EE;'>#老鹳草#</a>的提取物可使HIV-1型病毒失去活性,防止病毒侵入人体细胞。<a href='/topic/show?id=a48786e89c1' target=_blank style='color:#2F92EE;'>#艾滋病#</a><a href='/topic/show?id=edbd88e6e7' target=_blank style='color:#2F92EE;'>#HIV#</a> 从文献来看,很多天竺葵属植物均有作用。Plants like Rheum palmatum L., Rheum officinale, Trigonostem axyphophylloides, Vatica astrotricha, Vernonia amygdalina, Hypoxias pelargonium, Sidoides hemerocallidea and Sutherlandia frutescens etc. have high efficacy to cure HIV. 这里包括<a href='/topic/show?id=2c5110564699' target=_blank style='color:#2F92EE;'>#杏仁斑鸠菊#</a>、<a href='/topic/show?id=36aa10564e6b' target=_blank style='color:#2F92EE;'>#紫叶天竺葵#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=91, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=44192, encryptionId=d2e544192ed, topicName=天竺葵), TopicDto(id=80287, encryptionId=12958028e38, topicName=老鹳草), TopicDto(id=86789, encryptionId=a48786e89c1, topicName=艾滋病), TopicDto(id=8876, encryptionId=edbd88e6e7, topicName=HIV), TopicDto(id=105646, encryptionId=2c5110564699, topicName=杏仁斑鸠菊), TopicDto(id=105647, encryptionId=36aa10564e6b, topicName=紫叶天竺葵)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/Random/55971dc507c93968175ce7cc1e177b372a83869f.jpg, createdBy=f63e4754896, createdName=侠胆医心, createdTime=Sun Mar 12 10:16:21 CST 2023, time=2023-03-12, status=1, ipAttribution=上海), GetPortalCommentsPageByObjectIdResponse(id=1717173, encodeId=56671e17173a0, content=<a href='/topic/show?id=12958028e38' target=_blank style='color:#2F92EE;'>#老鹳草#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=80287, encryptionId=12958028e38, topicName=老鹳草)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=944632357610, createdName=qidongfanjian, createdTime=Wed Oct 22 08:49:00 CST 2014, time=2014-10-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1789569, encodeId=df0c1e8956999, content=<a href='/topic/show?id=6e4814388e2' target=_blank style='color:#2F92EE;'>#Plos one#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=14388, encryptionId=6e4814388e2, topicName=Plos one)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fda6311, createdName=119337457, createdTime=Tue Oct 07 17:49:00 CST 2014, time=2014-10-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1503607, encodeId=2542150360eee, content=<a href='/topic/show?id=d2e544192ed' target=_blank style='color:#2F92EE;'>#天竺葵#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=43, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=44192, encryptionId=d2e544192ed, topicName=天竺葵)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=99a09671720, createdName=karmond, createdTime=Mon Feb 10 01:49:00 CST 2014, time=2014-02-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=7236, encodeId=3e3de236e1, content=甘肃老中医以纯中药治疗艾滋病70余例,这个报道以前被人笑死了。现在看来,为什么不能呢?, beContent=null, objectType=article, channel=null, level=null, likeNumber=183, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=hhf, createdTime=Sat Feb 08 12:01:00 CST 2014, time=2014-02-08, status=1, ipAttribution=)]
    2014-02-08 hhf

    甘肃老中医以纯中药治疗艾滋病70余例,这个报道以前被人笑死了。现在看来,为什么不能呢?

    0