Science：肠道细菌可导致自身免疫性疾病

2018-03-12 佚名 sciencedaily

xin.C

医生/ 住院医师

耶鲁大学的一项新研究表明，在老鼠小肠内发现的细菌可以传播到其他器官，引发自身免疫反应。他们说，研究人员还发现，可以用抗生素或疫苗来抑制自身免疫反应，目的是针对这些细菌。

耶鲁大学的一项新研究表明，在老鼠小肠内发现的细菌可以传播到其他器官，引发自身免疫反应。他们说，研究人员还发现，可以用抗生素或疫苗来抑制自身免疫反应，目的是针对这些细菌。

研究人员说，这项发表在《科学》杂志上的研究结果表明，这是有前景的治疗慢性自身免疫疾病的新方法，包括系统性红斑狼疮和自身免疫性肝病。

肠道细菌与一系列疾病有关，包括免疫系统攻击健康组织的自身免疫状况。为了阐明这一联系，耶鲁大学的一个研究小组将重点放在了肠球菌，他们发现的一种细菌能够自发地在肠外“转移”到淋巴结、肝脏和脾脏。

在基因易感小鼠的模型中，研究人员观察到，在肠道外的组织中，E. gallinarum开始产生自体抗体和炎症，这是自身免疫反应的特征。他们证实了健康人培养的肝细胞的炎症机制，以及在自身免疫性疾病患者肝脏中存在这种细菌。

通过进一步的实验，研究小组发现他们可以用抗生素或针对E. gallinarum的疫苗来抑制小鼠的自身免疫。通过这两种方法，研究人员能够抑制组织中细菌的生长并减弱其对免疫系统的影响。

“当我们阻断导致炎症的途径时，我们可以逆转这种细菌对自身免疫的影响，”资深作家Martin Kriegel说。

他指出:“针对E. gallinarum的疫苗是一种特殊的方法，因为我们研究的其他细菌接种疫苗并不能预防死亡率和自身免疫。”这种疫苗是通过注射在肌肉中的，以避免瞄准肠道内的其他细菌。

他们说，虽然Kriegel和他的同事计划进一步研究E. gallinarum及其机制，但这些发现与系统性红斑狼疮和自身免疫性肝病相关。

他说:“使用抗生素和其他方法，如接种疫苗，是改善自身免疫性疾病患者生活的有效途径。”

原始出处：

S. Manfredo Vieira, M. Hiltensperger, V. Kumar, et.al. Translocation of a gut pathobiont drives autoimmunity in mice and humans. Science 09 Mar 2018

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2018-03-15 121d9982m19暂无昵称

学习了

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2018-03-15 121832a9m88暂无昵称

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2018-03-14 listen318

#肠道细菌#

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2018-03-14 jichang

#SCIE#

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2018-03-14 124988c7m100暂无昵称

#免疫性疾病#

46 0
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2018-03-13 cscdliu

学习了.谢谢

76 0
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2018-03-13 秀红

学习了

93 0

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