J Intern Med:体位性心动过速是诊断慢性疲劳综合征的有用指标吗?

2016-10-11 MedSci MedSci原创

背景:体位性心动过速综合征(POTS)被认为是慢性疲劳综合征(CFS)的诊断指标。 目的:本研究的目的是(i)比较CFS队列里,不符合CFS标准但伴疲劳的患者,其POTS患病率情况;(ii)评估伴POTS的CFS患者(POTS-CFS)、不伴POTS的CFS患者(non-POTS-CFS),对认知行为疗法(CBT)的活性、损害和反应。 方法:本项前瞻性队列研究在荷兰内梅亨大学医学中心进

背景:体位性心动过速综合征(POTS)被认为是慢性疲劳综合征(CFS)的诊断指标。

目的:本研究的目的是(i)比较CFS队列里,不符合CFS标准但伴疲劳的患者,其POTS患病率情况;(ii)评估伴POTS的CFS患者(POTS-CFS)、不伴POTS的CFS患者(non-POTS-CFS),对认知行为疗法(CBT)的活性、损害和反应。

方法:本项前瞻性队列研究在荷兰内梅亨大学医学中心进行。在2013年6月至2014年12月,对连续863例持续性疲劳患者进行了筛选。患者进行了积极的站立试验、填写了问卷、并戴着一个活动感测装置(为期12天)。

结果:共有419例CFS患者和341例非CFS疲劳患者纳入本研究;两组成人患者的POTS患病率分别为5.7%和6.9%(P = 0.54);两组青少年患者中的POTS患病率分别为18.2%和17.4%(P = 0.93)。与non-POTS-CFS患者相比,POTS-CFS患者更年轻(30 ± 12 vs. 40 ± 13岁, P = 0.001)、卧位心率更高(71 ± 11 vs. 65 ± 9 次/分, P = 0.009)。组间的严重程度和活动模式没有差异。CFS患者中,符合全身性劳累性疾病(SEID)标准的成人和青少年分别有76%和67%。符合SEID标准的CFS患者,总体CFS患者的POTS患病率没有差异。与non-POTS-CFS青少年患者相比,CBT后,POTS-CFS青少年患者的临床改善更差(58% vs. 88%, P = 0.017)。

结论:成人CFS的POTS患病率很低,并且与非CFS疲劳患者之间不存在POTS患病率的差异,此外POTS与疾病严重程度和治疗结果无关。青少年POTS-CFS患者CBT治疗后的成功率低于non-POTS-CFS患者。POTS对于CFS的诊断价值似乎是有限的。

原始出处:

M. E. Roerink, J. W. M. Lenders, I. C. Schmits, A. M. A. Pistorius, J. W. Smit, H. Knoop and J. W. M. van der Meer.Postural orthostatic tachycardia is not a useful diagnostic marker for chronic fatigue syndrome.J Intern Med.2 OCT 2016

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    2016-11-10 1dedfe95m66(暂无匿称)

    对头很对头,一累就体位性心动过速

    0

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    2016-10-13 tamgche
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