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盘点：JAMA 6月原始研究第四期汇总

2018-06-29 MedSci MedSci原创

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【1】呋喹替尼三线治疗转移性结肠癌效果显著doi:10.1001/jama.2018.7855转移性结直肠癌(CRC)患者的治疗手段十分有限，近日FRESCO为III期临床研究评估了血管内皮生长因子受体(VEGFR)抑制剂呋喹替尼三线治疗转移性CRC的疗效。研究在中国28个医疗中心开展，416名18-57岁先前接受过2种化疗（无VEGFR抑制疗法）后进展的CRC患者参与研究，随机接受5mg呋喹替尼

【1】呋喹替尼三线治疗转移性结肠癌效果显著

doi:10.1001/jama.2018.7855

转移性结直肠癌(CRC)患者的治疗手段十分有限，近日FRESCO为III期临床研究评估了血管内皮生长因子受体(VEGFR)抑制剂呋喹替尼三线治疗转移性CRC的疗效。研究在中国28个医疗中心开展，416名18-57岁先前接受过2种化疗（无VEGFR抑制疗法）后进展的CRC患者参与研究，随机接受5mg呋喹替尼或安慰剂，每天1次持续28天，中间停药7天后，再接受28天治疗，直至疾病进展、不可接受毒性或退出。最终97.1%的患者完成研究。结果显示，呋喹替尼组患者平均总生存期和无进展生存期显著延长。表明对于接受过2种化疗方案的转移性结肠癌患者，呋喹替尼治疗可显著延长患者生存期。

【2】人流操作相关疾病及不良反应是否与医院或门诊类型相关

doi:10.1001/jama.2018.7675

目前尚未可知人流机构类型与人流相关疾病和不良事件的发生时是否存在关联。近日，一项回顾性队列研究，纳入了49287名具有私人医疗保险的妇女，对其50311次人工流产进行分析。结果发现，日间门诊手术中心与办公室设置的流产相关并发症和不良事件的发生之间无明显差异 （校正比值比为0.97）。表明流产相关疾病和不良事件的发生率与流产手术中心与办公室设置无明显差异。

【3】抗血小板药物治疗导致的出血风险研究

doi:10.1001/jama.2018.8194

阿司匹林是有效的主要心血管疾病(CVD)事件的预防手段，而出血风险增加是其主要不良事件，但出血是由于阿司匹林治疗导致的还是其他药物因素目前尚无明确结论。近日研究人员就未接受抗血小板治疗的CVD风险人群的主要出血事件发生率进行了考察。研究在新西兰开展，359166名，30-79岁CVD风险人群参与，将参与者按每10岁划分为1个小组。在1281896个随访年中发生3976起出血事件，主要是胃肠道出血(n=2910 [73%])。发生了274起致命性出血(7%)，其中颅内出血153起。表明存在心血管疾病风险但未接受抗血小板治疗的人群中，其主要出血事件以及致死性出血事件的发生率与接受抗血小板治疗的人群相比未见显著降低。

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    2018-07-12 1e145228m78(暂无匿称)

    学习了.谢谢作者分享!

    0

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    2018-06-29 1ddf0692m34(暂无匿称)

    学习了.长知识

    0

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    2018-06-29 1dd8c52fm63(暂无匿称)

    了解了解.继续关注

    0

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    2018-06-29 zb1235672

    学习了!!!!!

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=331140, encodeId=29933311409e, content=学习了.谢谢作者分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3xJXLtMtt5B40XXuPjn9xn1rBhrM6fHLkX1hI86ZoWoPJkgDkZuJNKkBfBHOcRd1fAdezg7JlHNOokohdAp3WkI/0, createdBy=32c81964262, createdName=1e145228m78(暂无匿称), createdTime=Thu Jul 12 21:53:13 CST 2018, time=2018-07-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=327901, encodeId=58be32e901c6, content=学习了.长知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Fri Jun 29 07:32:56 CST 2018, time=2018-06-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=327895, encodeId=659532e895b1, content=了解了解.继续关注, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=93f31631454, createdName=1dd8c52fm63(暂无匿称), createdTime=Fri Jun 29 07:31:31 CST 2018, time=2018-06-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=327884, encodeId=4d5b32e88469, content=学习了!!!!!, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=59321624668, createdName=zb1235672, createdTime=Fri Jun 29 07:20:20 CST 2018, time=2018-06-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=327844, encodeId=e87f32e8442c, content=阅, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/09/07/a9772c74ffd6edc03a7f9af07b4747f6.jpg, createdBy=b3722138742, createdName=sunfeifeiyang, createdTime=Fri Jun 29 06:34:49 CST 2018, time=2018-06-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=327835, encodeId=556432e83583, content=优质资源.共同学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=10, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5K0LqDY57Aia0TOQByoJhNt3icm4sfukp500hLH6RHOpFdV01NbECtAV7s0qKpQPibyRukQAwAmqJU3X/0, createdBy=f91f1928792, createdName=九九消寒, createdTime=Fri Jun 29 06:12:53 CST 2018, time=2018-06-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=327828, encodeId=1aa032e828a1, content=好好好好好好好好, beContent=null, objectType=article, channel=null, level=null, likeNumber=9, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/08/29/bbc5cc0eed9b8d17623d2fd49dbdf19a.jpg, createdBy=79522135794, createdName=yjs木玉, createdTime=Fri Jun 29 05:45:07 CST 2018, time=2018-06-29, status=1, ipAttribution=)]
    2018-06-29 sunfeifeiyang

    阅

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=331140, encodeId=29933311409e, content=学习了.谢谢作者分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3xJXLtMtt5B40XXuPjn9xn1rBhrM6fHLkX1hI86ZoWoPJkgDkZuJNKkBfBHOcRd1fAdezg7JlHNOokohdAp3WkI/0, createdBy=32c81964262, createdName=1e145228m78(暂无匿称), createdTime=Thu Jul 12 21:53:13 CST 2018, time=2018-07-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=327901, encodeId=58be32e901c6, content=学习了.长知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Fri Jun 29 07:32:56 CST 2018, time=2018-06-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=327895, encodeId=659532e895b1, content=了解了解.继续关注, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=93f31631454, createdName=1dd8c52fm63(暂无匿称), createdTime=Fri Jun 29 07:31:31 CST 2018, time=2018-06-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=327884, encodeId=4d5b32e88469, content=学习了!!!!!, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=59321624668, createdName=zb1235672, createdTime=Fri Jun 29 07:20:20 CST 2018, time=2018-06-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=327844, encodeId=e87f32e8442c, content=阅, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/09/07/a9772c74ffd6edc03a7f9af07b4747f6.jpg, createdBy=b3722138742, createdName=sunfeifeiyang, createdTime=Fri Jun 29 06:34:49 CST 2018, time=2018-06-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=327835, encodeId=556432e83583, content=优质资源.共同学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=10, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5K0LqDY57Aia0TOQByoJhNt3icm4sfukp500hLH6RHOpFdV01NbECtAV7s0qKpQPibyRukQAwAmqJU3X/0, createdBy=f91f1928792, createdName=九九消寒, createdTime=Fri Jun 29 06:12:53 CST 2018, time=2018-06-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=327828, encodeId=1aa032e828a1, content=好好好好好好好好, beContent=null, objectType=article, channel=null, level=null, likeNumber=9, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/08/29/bbc5cc0eed9b8d17623d2fd49dbdf19a.jpg, createdBy=79522135794, createdName=yjs木玉, createdTime=Fri Jun 29 05:45:07 CST 2018, time=2018-06-29, status=1, ipAttribution=)]
    2018-06-29 九九消寒

    优质资源.共同学习

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=331140, encodeId=29933311409e, content=学习了.谢谢作者分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3xJXLtMtt5B40XXuPjn9xn1rBhrM6fHLkX1hI86ZoWoPJkgDkZuJNKkBfBHOcRd1fAdezg7JlHNOokohdAp3WkI/0, createdBy=32c81964262, createdName=1e145228m78(暂无匿称), createdTime=Thu Jul 12 21:53:13 CST 2018, time=2018-07-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=327901, encodeId=58be32e901c6, content=学习了.长知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Fri Jun 29 07:32:56 CST 2018, time=2018-06-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=327895, encodeId=659532e895b1, content=了解了解.继续关注, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=93f31631454, createdName=1dd8c52fm63(暂无匿称), createdTime=Fri Jun 29 07:31:31 CST 2018, time=2018-06-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=327884, encodeId=4d5b32e88469, content=学习了!!!!!, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=59321624668, createdName=zb1235672, createdTime=Fri Jun 29 07:20:20 CST 2018, time=2018-06-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=327844, encodeId=e87f32e8442c, content=阅, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/09/07/a9772c74ffd6edc03a7f9af07b4747f6.jpg, createdBy=b3722138742, createdName=sunfeifeiyang, createdTime=Fri Jun 29 06:34:49 CST 2018, time=2018-06-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=327835, encodeId=556432e83583, content=优质资源.共同学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=10, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib06iaV3D9Tg5K0LqDY57Aia0TOQByoJhNt3icm4sfukp500hLH6RHOpFdV01NbECtAV7s0qKpQPibyRukQAwAmqJU3X/0, createdBy=f91f1928792, createdName=九九消寒, createdTime=Fri Jun 29 06:12:53 CST 2018, time=2018-06-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=327828, encodeId=1aa032e828a1, content=好好好好好好好好, beContent=null, objectType=article, channel=null, level=null, likeNumber=9, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2017/08/29/bbc5cc0eed9b8d17623d2fd49dbdf19a.jpg, createdBy=79522135794, createdName=yjs木玉, createdTime=Fri Jun 29 05:45:07 CST 2018, time=2018-06-29, status=1, ipAttribution=)]
    2018-06-29 yjs木玉

    好好好好好好好好

    0