ARCH PATHOL LAB MED:儿童甲状腺结节甲状腺细胞病理学特征

2020-05-21 MedSci原创 MedSci原创

美国甲状腺协会的《甲状腺结节和分化型甲状腺癌患儿管理指南》建议将细针穿刺术(FNA)作为评估和治疗小儿甲状腺结节的重要工具。

美国甲状腺协会的《甲状腺结节和分化型甲状腺癌患儿管理指南》建议将细针穿刺术(FNA)作为评估和治疗小儿甲状腺结节的重要工具,并将Bethesda报告甲状腺细胞病变的系统(TBSRTC) 对FNA细胞学发现进行分类的指南。然而,也有一些出版文献关注儿童的TBSRTC分类。在此,研究人员评价了在儿科人群中使用TBSRTC的机构经验。

研究人员对2011年1月1日至2017年9月30日期间使用TBSRTC分类评估的21岁以下患者的甲状腺FNA标本进行了回顾性数据检索。与以前发表的成人经验相比,评估了细胞学和组织学诊断、手术随访率、组织学证实的恶性肿瘤率以及细胞学和组织学的一致性。

研究结果显示:在总共201份标本中,良性类别占103(51.2%),其次是恶性肿瘤35(17.4%),重要性未确定的非典型性/重要性未确定的卵泡病变(AUS / FLUS),14(7.0) %)非诊断性,10(5.0%)滤泡性肿瘤/对滤泡性肿瘤(FN / SFN)可疑,以及9(4.5%)对恶性肿瘤(SFM)分类。 随后在201例病例中有100例进行了手术(49.8%)。 由FNA分类为恶性和SFM的所有手术切除结节均显示恶性,而在不同比例的标本中,包括AUS / FLUS(16个中的5个; 31.3%),FN / SFN(9个中的1个; 11.1%)和 非诊断性(1/7; 14.2%)。 在良性类别中未发现恶性肿瘤。 细胞学-组织学一致性在恶性,SFM和FN / SFN类中达到100%,在良性和AUS / FLUS类中分别超过了85%和50%。

研究结果表明,TBSRTC对儿童甲状腺结节的正确分类是有效的。儿童患甲状腺结节恶性肿瘤的风险高于成人。了解儿童和成人在TBSRTC分类上的差异,可能有助于对儿童甲状腺结节进行更恰当的评估和管理。

原始出处:

Amer Heider, MD; Stacy Arnold, MD;Bethesda System for Reporting Thyroid Cytopathology in Pediatric Thyroid Nodules: Experience of a Tertiary Care Referral Center

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    2020-07-16 yb6560
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    2020-05-22 jktdtl
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    2020-05-22 智慧医人