Circ-Heart Fail:分析左心室逆向重构相关的MicroRNAs有助于识别心衰进展机制!

2018-02-10 xing.T MedSci原创

由此可见,人类左心室逆转重构相关的血浆miRNA在HF动脉模型中功能失调,并且这些miRNAs分子靶向参与HF相关机制的基因簇。整合人类HF、生物信息学和模型系统的转化手段可能会发现涉及HF发生的新机制。

近年来,血浆中细胞外RNA被作为心衰(HF)的生物标志物备受关注。有关HF的大多数研究集中在与表型和结局相关的单个细胞外RNA分子上,很少描述它们的功能作用。近日,心血管领域权威杂志Circ-Heart Fail上发表了一篇研究文章,研究人员假设与心衰患者左心室(LV)重构相关的血浆微小RNA(miRNA)簇将在动物模型中鉴定出与HF有关的新基因亚群。

研究人员前瞻性地测量了64例收缩期HF患者(平均年龄64.8岁; 91%男性;中位左心室射血分数为26%)循环中miRNAs分子,并在在药物治疗期间进行连续超声心动图检查(间隔10个月)。研究人员将LV逆向重构定义为LV收缩末期容量指数降低15%。

通过使用主成分分析,研究人员确定了与LV逆向重构相关的成分(比值比为3.99; P=0.01),这些成分优于临床模型提供了LV逆向重构风险判别(C统计量,临床模型为0.58,基于模型的RNA为0.71)。研究人员使用网络生物信息学,发现了以前在HF中被广泛描述的基因,这些基因同时被超过2个的miRNA进行调控。在动物HF发生发展过程中,研究人员观察到这些miRNA的心肌表达增加,靶基因表达下调,表明miRNA-mRNA调节一致。靶向的mRNA分子参与自噬、代谢和炎症。

由此可见,人类左心室逆转重构相关的血浆miRNA在HF动脉模型中功能失调,并且这些miRNAs分子靶向参与HF相关机制的基因簇。整合人类HF、生物信息学和模型系统的转化手段可能会发现涉及HF发生的新机制。

原始出处:


Ravi Shah,et al. MicroRNAs Associated With Reverse Left Ventricular Remodeling in Humans Identify Pathways of Heart Failure Progression. Circulation:heart failure. 2018. https://doi.org/10.1161/CIRCIMAGING.117.006955

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    2018-06-04 xjy02
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status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1435710, encodeId=265e1435e109c, content=<a href='/topic/show?id=31df11e1642' target=_blank style='color:#2F92EE;'>#microRNA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11716, encryptionId=31df11e1642, topicName=microRNA)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Mon Feb 12 08:56:00 CST 2018, time=2018-02-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1562826, encodeId=d00c1562826f6, content=<a href='/topic/show?id=f69d864413' target=_blank style='color:#2F92EE;'>#HEART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8644, encryptionId=f69d864413, topicName=HEART)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=30bd35, createdName=一叶知秋, createdTime=Mon Feb 12 08:56:00 CST 2018, time=2018-02-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=286851, encodeId=67a02868510f, content=学习一下谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLGSUSR8zwnWWLT4FMl5XH8S58HuZslVkLsAPbXDXaliagK7TOxQfmngKibG1yrDonepCLDkcxGk8hS/0, createdBy=b8282062892, createdName=changjiu, createdTime=Sat Feb 10 20:48:23 CST 2018, time=2018-02-10, status=1, ipAttribution=)]
    2018-02-13 海之蓝

    学习

    0

  6. 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status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1435710, encodeId=265e1435e109c, content=<a href='/topic/show?id=31df11e1642' target=_blank style='color:#2F92EE;'>#microRNA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11716, encryptionId=31df11e1642, topicName=microRNA)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=zhouqu_8, createdTime=Mon Feb 12 08:56:00 CST 2018, time=2018-02-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1562826, encodeId=d00c1562826f6, content=<a href='/topic/show?id=f69d864413' target=_blank style='color:#2F92EE;'>#HEART#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=8644, encryptionId=f69d864413, topicName=HEART)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=30bd35, createdName=一叶知秋, createdTime=Mon Feb 12 08:56:00 CST 2018, time=2018-02-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=286851, encodeId=67a02868510f, content=学习一下谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLGSUSR8zwnWWLT4FMl5XH8S58HuZslVkLsAPbXDXaliagK7TOxQfmngKibG1yrDonepCLDkcxGk8hS/0, createdBy=b8282062892, createdName=changjiu, createdTime=Sat Feb 10 20:48:23 CST 2018, time=2018-02-10, status=1, ipAttribution=)]
    2018-02-12 zhaojie88
  7. 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    2018-02-12 zhouqu_8
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    2018-02-10 changjiu

    学习一下谢谢

    0