Am J Epidemiol:高剂量叶酸补充摄入可以防止与交通相关的空气污染的不利生殖后果

2019-08-28 不详 网络

交通相关的空气污染与不孕和流产的风险增加有关。我们评估了叶酸摄入是否改变了接受辅助生殖技术(ART)的女性空气污染与活产之间的关系。研究纳入波士顿生育中心(2005-2015)提供的304名女性(513个周期)。通过食物频率问卷评估饮食和补充剂。使用时空模型估计在ART前三个月内基于居住的二氧化氮(NO2),臭氧,细颗粒和黑碳浓度。使用具有相互作用项的广义线性混合模型来评估校正年龄,BMI,种族,

交通相关的空气污染与不孕和流产的风险增加有关。我们评估了叶酸摄入是否改变了接受辅助生殖技术(ART)的女性空气污染与活产之间的关系。

研究纳入波士顿生育中心(2005-2015)提供的304名女性(513个周期)。通过食物频率问卷评估饮食和补充剂。使用时空模型估计在ART前三个月内基于居住的二氧化氮(NO2),臭氧,细颗粒和黑碳浓度。使用具有相互作用项的广义线性混合模型来评估校正年龄,BMI,种族,吸烟,教育,不孕症诊断和ART周期后空气污染物与活产之间的关联是否会因叶酸摄入而改变。补充叶酸摄入显著改变了NO2暴露与活产的关联(P = 0.01)。在补充叶酸摄入量<800μg/天的女性中,NO2暴露每增加20ppb,活产的几率降低24%(95%CI, 2,42%)。摄入量≥800μg/天的女性二者之间没有关联。叶酸对其他空气污染物与活产之间的关联没有影响。

高剂量叶酸补充摄入可以防止与交通相关的空气污染的不利生殖后果。

原始出处:

Gaskins AJ, Mínguez-Alarcón L, et al., Exposure to Traffic-Related Air Pollution, Supplemental Folate Intake, and Live Birth Among Women Undergoing Assisted Reproduction. Am J Epidemiol. 2019 Jun 26. pii: kwz151. doi: 10.1093/aje/kwz151.

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    2019-10-13 amy0550
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    2019-08-30 yuandd
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    2019-08-29 最帅小男护

    学习了

    0

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    2019-08-28 医者仁心5538

    学习了

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=1942113, encodeId=c5bc19421133a, content=<a href='/topic/show?id=065b1022341a' target=_blank style='color:#2F92EE;'>#高剂量#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102234, encryptionId=065b1022341a, topicName=高剂量)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=010d202, createdName=amy0550, createdTime=Sun Oct 13 19:44:00 CST 2019, time=2019-10-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1822223, encodeId=22c818222231e, content=<a href='/topic/show?id=5f2a102235ba' target=_blank style='color:#2F92EE;'>#高剂量叶酸#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102235, encryptionId=5f2a102235ba, topicName=高剂量叶酸)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=976a57, createdName=liubm555, createdTime=Sun Jul 19 06:44:00 CST 2020, time=2020-07-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1472654, encodeId=64ba14e265402, content=<a href='/topic/show?id=ba4a6436107' target=_blank style='color:#2F92EE;'>#污染#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=64361, encryptionId=ba4a6436107, topicName=污染)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=dfe67217539, createdName=小刀医生, createdTime=Fri Aug 30 13:44:00 CST 2019, time=2019-08-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1588852, encodeId=d480158885219, content=<a href='/topic/show?id=00742438078' target=_blank style='color:#2F92EE;'>#交通#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=24380, encryptionId=00742438078, topicName=交通)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=84fb17623791, createdName=yuandd, createdTime=Fri Aug 30 13:44:00 CST 2019, time=2019-08-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=371939, encodeId=a6c23e193970, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=65, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2019/07/01/577acf4668c2eb760152040cdd4c4196.jpg, createdBy=dc3f5107879, createdName=最帅小男护, createdTime=Thu Aug 29 00:01:36 CST 2019, time=2019-08-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=371938, encodeId=92c43e1938ff, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=82311653708, createdName=医者仁心5538, createdTime=Wed Aug 28 23:56:02 CST 2019, time=2019-08-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=371936, encodeId=581c3e19364e, content=好, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0aa31415219, createdName=orangesking, createdTime=Wed Aug 28 23:40:24 CST 2019, time=2019-08-28, status=1, ipAttribution=)]
    2019-08-28 orangesking

    0