Am J Transl Res:低强度脉冲超声可增强不同形貌钛表面骨髓间充质干细胞的成骨

2018-03-16 MedSci MedSci原创

低强度脉冲超声(LIPUS)是一种可促进骨生成的有前途的方法。然而,很少有研究报道这种技术对骨内种植体骨整合的影响,特别是对于不同的植体外形。本研究中,研究人员探究了LIPUS如何增强细胞与钛表面之间的初始相互作用及其潜在的调节机制。在LIPUS刺激或对照条件下,将大鼠的骨髓间充质干细胞(BMSCs)在两种类型的钛表面(光滑和SLA)上培养。结果显示,与对照组相比,LIPUS可明显促进种植体表面的

低强度脉冲超声(LIPUS)是一种可促进骨生成的有前途的方法。然而,很少有研究报道这种技术对骨内种植体骨整合的影响,特别是对于不同的植体外形。本研究中,研究人员探究了LIPUS如何增强细胞与钛表面之间的初始相互作用及其潜在的调节机制。

在LIPUS刺激或对照条件下,将大鼠的骨髓间充质干细胞(BMSCs)在两种类型的钛表面(光滑和SLA)上培养。结果显示,与对照组相比,LIPUS可明显促进种植体表面的细胞增殖,刺激微丝数量增加,伪足形成和细胞外基质矿化结节增多。通过LIPUS刺激两种钛表面上BMSCs的成骨相关基因(包括OPN,OCN,BMP-2,ALP,Runx2和Col-1)的表达上调。

综上所述,该研究结果表明,LIPUS增强了钛表面BMSCs的成骨细胞分化。LIPUS或是改善骨整合的潜在辅助治疗。

原始出处:

An Y, Song Y, et al., Effect of low-intensity pulsed ultrasound on the biological behaviors of bone marrow mesenchymal stem cells on titanium with different surface topographies. Am J Transl Res. 2018 Jan 15;10(1):67-76. eCollection 2018.

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    2018-10-24 30397613
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    2019-02-02 bsmagic9140
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    2018-03-18 zhaojie88