Lancet:2015年呼吸道合胞病毒引起的儿童急性下呼吸道感染概况

2017-07-07 qinqiyun MedSci原创

全球范围内,RSV是婴幼儿ALRI的常见病因,也是婴幼儿入院的主要原因,给健康医疗服务造成巨大负担。在婴幼儿中由RSV-ALRI导致的入院和院内死亡的45%是发生在6个月内的婴儿。

Ting Shi及其同事估测出2005年重度急性下呼吸道感染(ALRI)发作死亡的55000到199000名5岁以下幼儿中22%是与呼吸道合胞病毒(RSV)相关。在过去5年,关于RSV的主要研究工作是集中于发达国家中的新数据。通过大型国际合作,数据库有了很大的扩充。鉴于此,研究者致力评估2015年幼儿中RSV-ALRI全球范围的发病率、入院率和死亡率。

数据来源于1995年1月1日-2016年12月31日发表的系统回顾性研究和76个尚未发表的高质量的基于人口的研究,根据年龄和世界银行收入区域对数据进行分层,分析5岁以下幼儿RSV相关的ALRI(RSV-ALRI)的发病率和入院率。

通过风险因子基础模型和2015年估测人口来评估在132个发达国家的RSV-ALRI发病率。从以医院为基础的研究中结合估测的入院率,然后利用住院病例的死亡率来估算院内RSV-ALRI的死亡率。

据统计结果,2015年全球范围内在5岁以下的幼儿中,共3.31千万次RSV-ALRI发病,320万次入院和59600例院内死亡。在6个月内的婴儿中,由RSV-ALRI导致140万次入院和27300例院内死亡。RSV-ALRI的总体死亡数高达118 200例。在每个人群中,不同年龄的发病率和死亡率均有很大差别。

全球范围内,RSV是婴幼儿ALRI的常见病因,也是婴幼儿入院的主要原因,给健康医疗服务造成巨大负担。在婴幼儿中由RSV-ALRI导致的入院和院内死亡的45%是发生在6个月内的婴儿。有效的母体RSV疫苗或单克隆抗体或许可以减轻这一年龄群体的疾病负担。

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    2024-04-03 ms4000002039873510 来自河北省

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    2018-01-15 howi
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    2017-07-08 zhmscau
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