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BJC：IMM-101+GEM治疗胰腺癌

2016-09-15 Mechront 译 MedSci原创

IMM-101GEM胰腺癌吉西他滨
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Immune Modulation and Gemcitabine Evaluation-1（IMAGE-1）是一项随机、对照、开放标签、二期、一线、概念验证研究(NCT01303172)，评估了IMM-101（热灭活奥布分支杆菌; NCTC 13365）+吉西他滨(GEM)治疗晚期胰腺导管腺癌的有效性和安全性。 患者按2:1随机分为IMM-101 (10 mg /ml 皮内)+GEM (1

Immune Modulation and Gemcitabine Evaluation-1（IMAGE-1）是一项随机、对照、开放标签、二期、一线、概念验证研究(NCT01303172)，评估了IMM-101（热灭活奥布分支杆菌; NCTC 13365）+吉西他滨(GEM)治疗晚期胰腺导管腺癌的有效性和安全性。

患者按2:1随机分为IMM-101 (10 mg /ml 皮内)+GEM (1000 mg /m2 静脉注射; n=75)或单独GEM(n=35)组。对不良事件（AE）发生率进行安全性评估；收集了关于总体生存率（OS）、无进展生存率（PFS）和整体缓解率(ORR)等相关信息。

结果表明，IMM-101耐受性良好；不良事件和严重不良事件发生率在两组间相似。在意向治疗人群中，IMM-101+GEM组和单独GEM组患者的中位OS分别为6.7个月和5.6个月；虽然数据上看，IMM-101+GEM组更优，但是不具有统计学意义（HR, 0.68 (95% CI, 0.44–1.04, P=0.074）。对预定义的转移亚组(84%)进行分析，IMM-101+GEM组的OS显著改善，从4.4个月到7个月(HR, 0.54, 95% CI 0.33–0.87, P=0.01)。

结果表明，与单独GEM组相比，IMM-101+GEM是安全和耐受的，并且对转移性疾病患者的生存有益。在未来还需要进一步的研究来验证这一发现。

原始出处：

Angus G Dalgleish.et al.Randomised, open-label, phase II study of gemcitabine with and without IMM-101 for advanced pancreatic cancer.British Journal of Cancer advance online publication 6 September 2016

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    2017-04-30 仁心济世

    #IMM-101#

    0

  2. 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    2016-09-17 1e0d99ddm02(暂无匿称)

    学着了，分享一下！

    0

  3. 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    2016-09-17 1e0d99ddm02(暂无匿称)

    总结的很好！！

    0

  4. 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level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160601/IMG574E13FEE55F33222.jpg, createdBy=929c1478678, createdName=zibozhouping, createdTime=Fri Sep 16 16:52:00 CST 2016, time=2016-09-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=128654, encodeId=e3a41286546e, content=谢谢分享！, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160811/IMG57AC91915ACA64463.jpg, createdBy=9c351934462, createdName=知难而进, createdTime=Fri Sep 16 13:01:00 CST 2016, time=2016-09-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=128655, encodeId=7ef6128655bc, content=继续关注！, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160811/IMG57AC91915ACA64463.jpg, createdBy=9c351934462, createdName=知难而进, createdTime=Fri Sep 16 13:01:00 CST 2016, time=2016-09-16, status=1, ipAttribution=)]
    2016-09-17 lhl629

    很好的内容，继续学习。

    0

  5. 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likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160811/IMG57AC91915ACA64463.jpg, createdBy=9c351934462, createdName=知难而进, createdTime=Fri Sep 16 13:01:00 CST 2016, time=2016-09-16, status=1, ipAttribution=)]
    2016-09-17 1dee1b88m43(暂无匿称)

    学习一下！

    0

  6. 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level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160601/IMG574E13FEE55F33222.jpg, createdBy=929c1478678, createdName=zibozhouping, createdTime=Fri Sep 16 16:52:00 CST 2016, time=2016-09-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=128654, encodeId=e3a41286546e, content=谢谢分享！, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160811/IMG57AC91915ACA64463.jpg, createdBy=9c351934462, createdName=知难而进, createdTime=Fri Sep 16 13:01:00 CST 2016, time=2016-09-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=128655, encodeId=7ef6128655bc, content=继续关注！, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160811/IMG57AC91915ACA64463.jpg, createdBy=9c351934462, createdName=知难而进, createdTime=Fri Sep 16 13:01:00 CST 2016, time=2016-09-16, status=1, ipAttribution=)]
    2016-09-16 doctorJiangchao

    继续关注

    0

  7. 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createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzfPkmqRTH5rHib5mcib8Wb3QdXjhfOK1UubQL2lictjJFdFJ6Lc3cnnCOSWqxXZ4Kk6y5GdzDoy764R/0, createdBy=156e1644785, createdName=doctorJiangchao, createdTime=Fri Sep 16 21:43:00 CST 2016, time=2016-09-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=128909, encodeId=f340128909b0, content=继续学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzfPkmqRTH5rHib5mcib8Wb3QdXjhfOK1UubQL2lictjJFdFJ6Lc3cnnCOSWqxXZ4Kk6y5GdzDoy764R/0, createdBy=156e1644785, createdName=doctorJiangchao, createdTime=Fri Sep 16 21:42:00 CST 2016, time=2016-09-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=128755, encodeId=6210128e55af, content=罕见病例，其实就是帮助我们以后行医路上凡事多点思考，不要只钉一点, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160601/IMG574E13FEE55F33222.jpg, createdBy=929c1478678, createdName=zibozhouping, createdTime=Fri Sep 16 16:52:00 CST 2016, time=2016-09-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=128654, encodeId=e3a41286546e, content=谢谢分享！, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160811/IMG57AC91915ACA64463.jpg, createdBy=9c351934462, createdName=知难而进, createdTime=Fri Sep 16 13:01:00 CST 2016, time=2016-09-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=128655, encodeId=7ef6128655bc, content=继续关注！, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160811/IMG57AC91915ACA64463.jpg, createdBy=9c351934462, createdName=知难而进, createdTime=Fri Sep 16 13:01:00 CST 2016, time=2016-09-16, status=1, ipAttribution=)]
    2016-09-16 doctorJiangchao

    继续学习

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=2081295, encodeId=af9c2081295c9, content=<a href='/topic/show?id=34dd9e6572' target=_blank style='color:#2F92EE;'>#IMM-101#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9765, encryptionId=34dd9e6572, topicName=IMM-101)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=仁心济世, createdTime=Sun Apr 30 10:11:00 CST 2017, time=2017-04-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=129751, encodeId=9e9d129e51ee, content=学着了，分享一下！, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, 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createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzfPkmqRTH5rHib5mcib8Wb3QdXjhfOK1UubQL2lictjJFdFJ6Lc3cnnCOSWqxXZ4Kk6y5GdzDoy764R/0, createdBy=156e1644785, createdName=doctorJiangchao, createdTime=Fri Sep 16 21:43:00 CST 2016, time=2016-09-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=128909, encodeId=f340128909b0, content=继续学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzfPkmqRTH5rHib5mcib8Wb3QdXjhfOK1UubQL2lictjJFdFJ6Lc3cnnCOSWqxXZ4Kk6y5GdzDoy764R/0, createdBy=156e1644785, createdName=doctorJiangchao, createdTime=Fri Sep 16 21:42:00 CST 2016, time=2016-09-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=128755, encodeId=6210128e55af, content=罕见病例，其实就是帮助我们以后行医路上凡事多点思考，不要只钉一点, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160601/IMG574E13FEE55F33222.jpg, createdBy=929c1478678, createdName=zibozhouping, createdTime=Fri Sep 16 16:52:00 CST 2016, time=2016-09-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=128654, encodeId=e3a41286546e, content=谢谢分享！, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160811/IMG57AC91915ACA64463.jpg, createdBy=9c351934462, createdName=知难而进, createdTime=Fri Sep 16 13:01:00 CST 2016, time=2016-09-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=128655, encodeId=7ef6128655bc, content=继续关注！, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160811/IMG57AC91915ACA64463.jpg, createdBy=9c351934462, createdName=知难而进, createdTime=Fri Sep 16 13:01:00 CST 2016, time=2016-09-16, status=1, ipAttribution=)]
    2016-09-16 zibozhouping

    罕见病例，其实就是帮助我们以后行医路上凡事多点思考，不要只钉一点

    0

  9. [GetPortalCommentsPageByObjectIdResponse(id=2081295, encodeId=af9c2081295c9, content=<a href='/topic/show?id=34dd9e6572' target=_blank style='color:#2F92EE;'>#IMM-101#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9765, encryptionId=34dd9e6572, topicName=IMM-101)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=仁心济世, createdTime=Sun Apr 30 10:11:00 CST 2017, time=2017-04-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=129751, encodeId=9e9d129e51ee, content=学着了，分享一下！, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, 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level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160601/IMG574E13FEE55F33222.jpg, createdBy=929c1478678, createdName=zibozhouping, createdTime=Fri Sep 16 16:52:00 CST 2016, time=2016-09-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=128654, encodeId=e3a41286546e, content=谢谢分享！, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160811/IMG57AC91915ACA64463.jpg, createdBy=9c351934462, createdName=知难而进, createdTime=Fri Sep 16 13:01:00 CST 2016, time=2016-09-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=128655, encodeId=7ef6128655bc, content=继续关注！, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160811/IMG57AC91915ACA64463.jpg, createdBy=9c351934462, createdName=知难而进, createdTime=Fri Sep 16 13:01:00 CST 2016, time=2016-09-16, status=1, ipAttribution=)]
    2016-09-16 知难而进

    谢谢分享！

    0

  10. 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level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160601/IMG574E13FEE55F33222.jpg, createdBy=929c1478678, createdName=zibozhouping, createdTime=Fri Sep 16 16:52:00 CST 2016, time=2016-09-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=128654, encodeId=e3a41286546e, content=谢谢分享！, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160811/IMG57AC91915ACA64463.jpg, createdBy=9c351934462, createdName=知难而进, createdTime=Fri Sep 16 13:01:00 CST 2016, time=2016-09-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=128655, encodeId=7ef6128655bc, content=继续关注！, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160811/IMG57AC91915ACA64463.jpg, createdBy=9c351934462, createdName=知难而进, createdTime=Fri Sep 16 13:01:00 CST 2016, time=2016-09-16, status=1, ipAttribution=)]
    2016-09-16 知难而进

    继续关注！

    0

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