Clinica Chimica Acta:血浆癌抗原(CA)-125水平与导管消融术后房颤复发1年的关系如何?

2020-04-12 MedSci原创 MedSci原创

既往研究表明,血浆癌抗原125 (CA-125)与心力衰竭和新发房颤(AF)密切相关,但尚无研究报道CA-125浓度与房颤消融晚期复发的关系。本研究首次将CA-125作为消融后房颤复发的生物标志物。

既往研究表明,血浆癌抗原125 (CA-125)与心力衰竭和新发房颤(AF)密切相关,但尚无研究报道CA-125浓度与房颤消融晚期复发的关系。本研究首次将CA-125作为消融后房颤复发的生物标志物。

本研究共纳入422例房颤患者接受导管消融治疗。随访1年,326例(77.25%)患者维持窦性心律,83例(20.44%)患者出现房颤复发。房颤复发患者基线CA-125浓度高于窦性心律维持者(P = 0.0001)。多因素Cox比例风险回归分析显示持续性房颤(HR 2.212;95% CI: 1.396-3.504, P = 0.001; CA-125浓度(HR, 1.003;95% (CI): 1.000-1.005, P = 0.019)是AF复发的独立预测因子。根据ROC分析,CA-125最佳截断值为11.05 U/ml,其敏感性和特异性分别达到65.6%和85.0%。曲线下面积(AUC)值为80.3% (95% CI: 0.750-0.857, P < 0.0001)。亚组分析结果提示持续性房颤患者CA-125浓度较高,房颤复发风险增加。

研究结果表明,高CA-125浓度是房颤消融1年后房颤复发的独立预测因子,特别是对持续性房颤患者。

原始出处:

Zhouqing Huang,Xiaohe Liang,Relationship between plasma cancer antigen (CA)-125 level and one-year recurrence of atrial fibrillation after catheter ablation

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topicList=[TopicDto(id=5385, encryptionId=61815385aa, topicName=CTA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ec9955, createdName=windight, createdTime=Mon Sep 07 08:40:29 CST 2020, time=2020-09-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1399627, encodeId=9253139962e93, content=<a href='/topic/show?id=9a0546e31b5' target=_blank style='color:#2F92EE;'>#导管消融#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=46731, encryptionId=9a0546e31b5, topicName=导管消融)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fd042221840, createdName=wjcjjian, createdTime=Tue Apr 14 12:40:29 CST 2020, time=2020-04-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1421809, encodeId=cc5a1421809ff, content=<a href='/topic/show?id=4bc865819d2' target=_blank style='color:#2F92EE;'>#消融#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=65819, encryptionId=4bc865819d2, topicName=消融)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1a193676008, createdName=xiangyuzhou972, createdTime=Tue Apr 14 12:40:29 CST 2020, time=2020-04-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1560286, encodeId=8a1a15602860d, content=<a href='/topic/show?id=a9fd65826da' target=_blank style='color:#2F92EE;'>#消融术#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=65826, encryptionId=a9fd65826da, topicName=消融术)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1c4415117207, createdName=dingxiaobo, createdTime=Tue Apr 14 12:40:29 CST 2020, time=2020-04-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1566295, encodeId=c2ec1566295e3, content=<a href='/topic/show?id=a9fd65826da' target=_blank style='color:#2F92EE;'>#消融术#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=65826, encryptionId=a9fd65826da, topicName=消融术)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1c4415117207, createdName=dingxiaobo, createdTime=Tue Apr 14 12:40:29 CST 2020, time=2020-04-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1623370, encodeId=174716233e033, content=<a href='/topic/show?id=62a655263e9' target=_blank style='color:#2F92EE;'>#抗原#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55263, encryptionId=62a655263e9, topicName=抗原)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f59b20519025, createdName=xiaoyeshuang, createdTime=Tue Apr 14 12:40:29 CST 2020, time=2020-04-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1031257, encodeId=7b94103125ebd, content=房颤,临床上碰到很多哦, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=心介, createdTime=Mon Apr 13 00:40:29 CST 2020, time=2020-04-13, status=1, ipAttribution=)]
    2020-09-07 windight
  5. 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topicList=[TopicDto(id=5385, encryptionId=61815385aa, topicName=CTA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ec9955, createdName=windight, createdTime=Mon Sep 07 08:40:29 CST 2020, time=2020-09-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1399627, encodeId=9253139962e93, content=<a href='/topic/show?id=9a0546e31b5' target=_blank style='color:#2F92EE;'>#导管消融#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=46731, encryptionId=9a0546e31b5, topicName=导管消融)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fd042221840, createdName=wjcjjian, createdTime=Tue Apr 14 12:40:29 CST 2020, time=2020-04-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1421809, encodeId=cc5a1421809ff, content=<a href='/topic/show?id=4bc865819d2' target=_blank style='color:#2F92EE;'>#消融#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=65819, encryptionId=4bc865819d2, topicName=消融)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1a193676008, createdName=xiangyuzhou972, createdTime=Tue Apr 14 12:40:29 CST 2020, time=2020-04-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1560286, encodeId=8a1a15602860d, content=<a href='/topic/show?id=a9fd65826da' target=_blank style='color:#2F92EE;'>#消融术#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=65826, encryptionId=a9fd65826da, topicName=消融术)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1c4415117207, createdName=dingxiaobo, createdTime=Tue Apr 14 12:40:29 CST 2020, time=2020-04-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1566295, encodeId=c2ec1566295e3, content=<a href='/topic/show?id=a9fd65826da' target=_blank style='color:#2F92EE;'>#消融术#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=65826, encryptionId=a9fd65826da, topicName=消融术)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1c4415117207, createdName=dingxiaobo, createdTime=Tue Apr 14 12:40:29 CST 2020, time=2020-04-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1623370, encodeId=174716233e033, content=<a href='/topic/show?id=62a655263e9' target=_blank style='color:#2F92EE;'>#抗原#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55263, encryptionId=62a655263e9, topicName=抗原)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f59b20519025, createdName=xiaoyeshuang, createdTime=Tue Apr 14 12:40:29 CST 2020, time=2020-04-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1031257, encodeId=7b94103125ebd, content=房颤,临床上碰到很多哦, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=心介, createdTime=Mon Apr 13 00:40:29 CST 2020, time=2020-04-13, status=1, ipAttribution=)]
  6. [GetPortalCommentsPageByObjectIdResponse(id=1700446, encodeId=20b91e004464f, content=<a href='/topic/show?id=6ccb46e37c7' target=_blank style='color:#2F92EE;'>#导管消融术#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=46737, encryptionId=6ccb46e37c7, topicName=导管消融术)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a1ab30095571, createdName=yourmama, createdTime=Sun Feb 28 08:40:29 CST 2021, time=2021-02-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2066837, encodeId=eaba206683ea7, content=<a href='/topic/show?id=fe1a6106394' target=_blank style='color:#2F92EE;'>#术后房颤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=61063, encryptionId=fe1a6106394, topicName=术后房颤)], attachment=null, authenticateStatus=null, createdAvatar=, 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topicList=[TopicDto(id=5385, encryptionId=61815385aa, topicName=CTA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ec9955, createdName=windight, createdTime=Mon Sep 07 08:40:29 CST 2020, time=2020-09-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1399627, encodeId=9253139962e93, content=<a href='/topic/show?id=9a0546e31b5' target=_blank style='color:#2F92EE;'>#导管消融#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=46731, encryptionId=9a0546e31b5, topicName=导管消融)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fd042221840, createdName=wjcjjian, createdTime=Tue Apr 14 12:40:29 CST 2020, time=2020-04-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1421809, encodeId=cc5a1421809ff, content=<a href='/topic/show?id=4bc865819d2' target=_blank style='color:#2F92EE;'>#消融#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=65819, encryptionId=4bc865819d2, topicName=消融)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1a193676008, createdName=xiangyuzhou972, createdTime=Tue Apr 14 12:40:29 CST 2020, time=2020-04-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1560286, encodeId=8a1a15602860d, content=<a href='/topic/show?id=a9fd65826da' target=_blank style='color:#2F92EE;'>#消融术#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=65826, encryptionId=a9fd65826da, topicName=消融术)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1c4415117207, createdName=dingxiaobo, createdTime=Tue Apr 14 12:40:29 CST 2020, time=2020-04-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1566295, encodeId=c2ec1566295e3, content=<a href='/topic/show?id=a9fd65826da' target=_blank style='color:#2F92EE;'>#消融术#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=65826, encryptionId=a9fd65826da, topicName=消融术)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1c4415117207, createdName=dingxiaobo, createdTime=Tue Apr 14 12:40:29 CST 2020, time=2020-04-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1623370, encodeId=174716233e033, content=<a href='/topic/show?id=62a655263e9' target=_blank style='color:#2F92EE;'>#抗原#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=21, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=55263, encryptionId=62a655263e9, topicName=抗原)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f59b20519025, createdName=xiaoyeshuang, createdTime=Tue Apr 14 12:40:29 CST 2020, time=2020-04-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1031257, encodeId=7b94103125ebd, content=房颤,临床上碰到很多哦, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=心介, createdTime=Mon Apr 13 00:40:29 CST 2020, time=2020-04-13, status=1, ipAttribution=)]
  7. [GetPortalCommentsPageByObjectIdResponse(id=1700446, encodeId=20b91e004464f, content=<a href='/topic/show?id=6ccb46e37c7' target=_blank style='color:#2F92EE;'>#导管消融术#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=46737, encryptionId=6ccb46e37c7, topicName=导管消融术)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a1ab30095571, createdName=yourmama, createdTime=Sun Feb 28 08:40:29 CST 2021, time=2021-02-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2066837, encodeId=eaba206683ea7, content=<a href='/topic/show?id=fe1a6106394' target=_blank style='color:#2F92EE;'>#术后房颤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=61063, encryptionId=fe1a6106394, topicName=术后房颤)], attachment=null, authenticateStatus=null, createdAvatar=, 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topicList=[TopicDto(id=5385, encryptionId=61815385aa, topicName=CTA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ec9955, createdName=windight, createdTime=Mon Sep 07 08:40:29 CST 2020, time=2020-09-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1399627, encodeId=9253139962e93, content=<a href='/topic/show?id=9a0546e31b5' target=_blank style='color:#2F92EE;'>#导管消融#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=46731, encryptionId=9a0546e31b5, topicName=导管消融)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=fd042221840, createdName=wjcjjian, createdTime=Tue Apr 14 12:40:29 CST 2020, time=2020-04-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1421809, encodeId=cc5a1421809ff, content=<a href='/topic/show?id=4bc865819d2' target=_blank style='color:#2F92EE;'>#消融#</a>, beContent=null, 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  8. 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  9. 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  10. 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Apr 14 12:40:29 CST 2020, time=2020-04-14, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1031257, encodeId=7b94103125ebd, content=房颤,临床上碰到很多哦, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=心介, createdTime=Mon Apr 13 00:40:29 CST 2020, time=2020-04-13, status=1, ipAttribution=)]
    2020-04-13 心介

    房颤,临床上碰到很多哦

    0