J Indian Soc Periodontol:Inersan®和/或多西环素治疗侵袭性牙周炎的长期效果

2018-03-03 MedSci MedSci原创

抗生素的过度使用和广泛使用是导致耐药微生物出现的原因,这些药物也干扰了机体微生物菌群,其中包括口腔中的乳酸杆菌。因此,最好避免使用抗生素。 在这项研究中测试的假设是用短乳杆菌CD2锭剂,短乳杆菌CD2与口服多西环素或单独使用强力霉素治疗14天对患者5个月后牙周健康具有有益效果。 18名年龄在14-35岁,具有侵袭性牙周炎的不吸烟患者被随机分配接受14天的乳杆菌CD2锭剂(每日两锭),口服强力霉素的

抗生素的过度使用和广泛使用是导致耐药微生物出现的原因,这些药物也干扰了机体微生物菌群,其中包括口腔中的乳酸杆菌。因此,最好避免使用抗生素

在这项研究中测试的假设是用短乳杆菌CD2锭剂,短乳杆菌CD2与口服多西环素或单独使用强力霉素治疗14天对患者5个月后牙周健康具有有益效果。

18名年龄在14-35岁,具有侵袭性牙周炎的不吸烟患者被随机分配接受14天的乳杆菌CD2锭剂(每日两锭),口服强力霉素的短乳杆菌CD2锭剂(每天一次100mg片剂)或单独使用强力霉素。在第0,2周,2个月和5个月时取唾液样品。评估临床参数(菌斑指数,牙龈指数,探查深度和临床附着水平)和微生物参数(乳酸杆菌和伴放线聚集杆菌)。组间变化使用重复测量方差分析进行评估。

结果显示,与基线相比,三组所有临床参数均在5个月时均得到改善。牙龈指数的改善(P <0.01)有统计学意义,组间差异也有统计学意义(P <0.01)。

表明使用含短乳杆菌CD2的锭剂治疗14天对侵袭性牙周炎的临床表现,特别是牙龈指数具有持久的作用。这种效应似乎与多西环素产生的效果相同。

原始出处:

Shah MP, Gujjari SK, Chandrasekhar VS. Long-term effect of Lactobacillus brevis CD2 (Inersan®) and/or doxycycline in aggressive periodontitis. J Indian Soc Periodontol. 2017 Jul-Aug;21(4):341-343. doi: 10.4103/jisp.jisp_215_17.

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    2019-02-04 anminleiryan
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    2019-01-31 feather89
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time=2018-03-05, status=1, ipAttribution=)]
  5. 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href='/topic/show?id=211f98250b' target=_blank style='color:#2F92EE;'>#IND#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9825, encryptionId=211f98250b, topicName=IND)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=16377007930, createdName=xiaogang319, createdTime=Mon Mar 05 06:48:00 CST 2018, time=2018-03-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1536761, encodeId=cb4f1536e6110, content=<a href='/topic/show?id=b38d2e011a6' target=_blank style='color:#2F92EE;'>#侵袭性牙周炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=27011, encryptionId=b38d2e011a6, topicName=侵袭性牙周炎)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=26c712719796, createdName=photoman, createdTime=Mon Mar 05 06:48:00 CST 2018, time=2018-03-05, status=1, ipAttribution=)]
    2018-03-05 sunyl07
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  7. 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href='/topic/show?id=211f98250b' target=_blank style='color:#2F92EE;'>#IND#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=9825, encryptionId=211f98250b, topicName=IND)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=16377007930, createdName=xiaogang319, createdTime=Mon Mar 05 06:48:00 CST 2018, time=2018-03-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1536761, encodeId=cb4f1536e6110, content=<a href='/topic/show?id=b38d2e011a6' target=_blank style='color:#2F92EE;'>#侵袭性牙周炎#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=27011, encryptionId=b38d2e011a6, topicName=侵袭性牙周炎)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=26c712719796, createdName=photoman, createdTime=Mon Mar 05 06:48:00 CST 2018, time=2018-03-05, status=1, ipAttribution=)]
    2018-03-05 xiaogang319
  9. 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