Radiology:特发性REM睡眠障碍黑质高信号会丢失?

2018-02-24 shaosai MedSci原创

本研究旨在验证是否3.0T磁共振磁敏感(SW)加权图像有助于识别特发性快速动眼睡眠障碍(iRBD)患者罹患蛋白病高风险的价值,并将结果发表在Radiology上。

本研究旨在验证是否3.0T磁共振磁敏感(SW)加权图像有助于识别特发性快速动眼睡眠障碍(iRBD)患者罹患蛋白病高风险的价值,并将结果发表在Radiology上。

本研究共纳入了18例患有iRBD的患者,并行3.0T SW成像及123I-FP-CIT SPECT成像,并与18例健康志愿者及18例帕金森病(PD)患者进行比较。由两位阅片者独立地评价图像。利用Kruskal-Wallis 检验评价123I-FP-CIT 摄入率,利用Cohen κ评价组间及组内一致性。根据NH状态,评价iRBD患者随访后蛋白病转变情况。

结果为,在7例iRBD患者中NH完整,11例患者消失。在7例NH完整的患者(平均3.22 ± 0.47)和健康志愿者(评价3.37 ± 0.47)的123I-FP-CIT摄入率相似。在11例iRBD且有NH丢失患者(平均为, 2.48 ± 0.44)中123I-FP-CIT摄入率明显低于健康志愿者(平均为, 3.37 ± 0.47; P < .001)但较PD患者(平均为, 1.80 ± 0.33; P < .001)高。组间和组内一致性均较好(κ > 0.9)。有5例iRBD且NH丢失的患者在神经成像的18个月后出现帕金森或痴呆征象。

本研究表明,3.0T SW成像可以作为iRBD患者发生短期蛋白质病风险的有利工具。

原始出处:


10.1148/radiol.2017162486

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  2. [GetPortalCommentsPageByObjectIdResponse(id=1950805, encodeId=24411950805c0, content=<a href='/topic/show?id=20101021e97e' target=_blank style='color:#2F92EE;'>#高信号#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102179, encryptionId=20101021e97e, topicName=高信号)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=08e4137, createdName=meichuangyi, createdTime=Sun Mar 11 19:27:00 CST 2018, time=2018-03-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1752235, encodeId=ab681e522352d, content=<a href='/topic/show?id=28a915303ec' target=_blank style='color:#2F92EE;'>#REM#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=18, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15303, encryptionId=28a915303ec, topicName=REM)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=78bc36479935, createdName=tongyongming, createdTime=Fri Mar 09 11:27:00 CST 2018, time=2018-03-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1894653, encodeId=7d1d1894653eb, content=<a href='/topic/show?id=e45b6e859f3' target=_blank style='color:#2F92EE;'>#特发性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67859, encryptionId=e45b6e859f3, topicName=特发性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=74808, createdName=xinxin088, createdTime=Tue Aug 07 03:27:00 CST 2018, time=2018-08-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=290479, encodeId=50762904e982, content=审稿仔细点吧-错别字好明显, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0df12168374, createdName=120485aam73暂无昵称, createdTime=Sat Feb 24 10:07:38 CST 2018, time=2018-02-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=290366, encodeId=934c2903663c, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a8f22260741, createdName=121832a9m88暂无昵称, createdTime=Sat Feb 24 06:25:59 CST 2018, time=2018-02-24, status=1, ipAttribution=)]
    2018-03-09 tongyongming
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  4. [GetPortalCommentsPageByObjectIdResponse(id=1950805, encodeId=24411950805c0, content=<a href='/topic/show?id=20101021e97e' target=_blank style='color:#2F92EE;'>#高信号#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=102179, encryptionId=20101021e97e, topicName=高信号)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=08e4137, createdName=meichuangyi, createdTime=Sun Mar 11 19:27:00 CST 2018, time=2018-03-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1752235, encodeId=ab681e522352d, content=<a href='/topic/show?id=28a915303ec' target=_blank style='color:#2F92EE;'>#REM#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=18, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15303, encryptionId=28a915303ec, topicName=REM)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=78bc36479935, createdName=tongyongming, createdTime=Fri Mar 09 11:27:00 CST 2018, time=2018-03-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1894653, encodeId=7d1d1894653eb, content=<a href='/topic/show?id=e45b6e859f3' target=_blank style='color:#2F92EE;'>#特发性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67859, encryptionId=e45b6e859f3, topicName=特发性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=74808, createdName=xinxin088, createdTime=Tue Aug 07 03:27:00 CST 2018, time=2018-08-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=290479, encodeId=50762904e982, content=审稿仔细点吧-错别字好明显, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0df12168374, createdName=120485aam73暂无昵称, createdTime=Sat Feb 24 10:07:38 CST 2018, time=2018-02-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=290366, encodeId=934c2903663c, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a8f22260741, createdName=121832a9m88暂无昵称, createdTime=Sat Feb 24 06:25:59 CST 2018, time=2018-02-24, status=1, ipAttribution=)]
    2018-02-24 120485aam73暂无昵称

    审稿仔细点吧-错别字好明显

    0

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    2018-02-24 121832a9m88暂无昵称

    学习了

    0