JAMA Neurol:轻微创伤性脑损伤同样增加后继痴呆风险

2018-05-08 zhangfan MedSci原创

研究发现,即便是轻微创伤性脑损伤且未出现意识丧失,这也会导致患者的痴呆风险较常人增加2倍

创伤性脑损伤(TBI)发病率较高,特别是军人群体。先前的研究发现中重度TBI导致痴呆风险增加,但痴呆与轻微TBI,特别是非意识丧失性(LOC)轻微TBI之间的关系尚不清楚。近日研究人员在退伍军人群体中考察了TBI程度、LOC与痴呆之间的关系。

伊拉克和阿富汗的退伍军人参与本次研究。根据最严重的脑创伤记录确定TBI程度,并分为轻微TBI非LOC、轻微TBI伴LOC、轻微TBI但LOC状态不详、中度TBI以及严重TBI。研究的主要终点是TBI与非TBI人群痴呆发病率差异。

总计178779名TBI患者以及178799名对照志愿者参与研究。参与者平均基线年龄49岁,女性占9.3%,非西班牙裔白人占72.5%。非TBI人群中,4698人患痴呆(2.6%),而TBI人群中10835人发病(6.1%)。调整人口统计、医疗和精神疾病因素后,轻微TBI非LOC人群的痴呆风险较对照组增加2.36倍,轻微TBI伴LOC人群的痴呆风险增加2.51倍,轻微TBI但LOC状态不详人群的痴呆风险增加3.19倍,而中重度TBI人群的痴呆风险增加3.77倍。

研究发现,即便是轻微创伤性脑损伤且未出现意识丧失,这也会导致患者的痴呆风险较常人增加2倍。

原始出处:


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    2019-04-11 amyloid
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    2018-10-11 heli0118
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status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=313186, encodeId=a6cd31318645, content=创伤性脑损伤(TBI)发病率较高.特别是军人群体.先前的研究发现中重度TBI导致痴呆风险增加.但痴呆与轻微TBI.特别是非意识丧失性(LOC)轻微TBI之间的关系尚不清楚.近日研究人员在退伍军人群体中考察了TBI程度.LOC与痴呆之间的关系., beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7cJ6ejWUr2nIia8qOvAKNdLHr32Df6G8iaoaOx6pHaoiacwp26DaslxZHCGbibZhhCGven4rvmWP60GahtzgFjgCjR/0, createdBy=6b111703011, createdName=有备才能无患, createdTime=Tue May 08 15:24:26 CST 2018, time=2018-05-08, status=1, ipAttribution=)]
    2018-05-10 vera_1203
  5. 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status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=313186, encodeId=a6cd31318645, content=创伤性脑损伤(TBI)发病率较高.特别是军人群体.先前的研究发现中重度TBI导致痴呆风险增加.但痴呆与轻微TBI.特别是非意识丧失性(LOC)轻微TBI之间的关系尚不清楚.近日研究人员在退伍军人群体中考察了TBI程度.LOC与痴呆之间的关系., beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7cJ6ejWUr2nIia8qOvAKNdLHr32Df6G8iaoaOx6pHaoiacwp26DaslxZHCGbibZhhCGven4rvmWP60GahtzgFjgCjR/0, createdBy=6b111703011, createdName=有备才能无患, createdTime=Tue May 08 15:24:26 CST 2018, time=2018-05-08, status=1, ipAttribution=)]
  6. 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ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=313197, encodeId=270531319e57, content=了解一下.谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=88, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2019/12/23/2f51002e1349ccda5be11c1eea1e1e60.jpg, createdBy=a22097948, createdName=天地飞扬, createdTime=Tue May 08 15:46:45 CST 2018, time=2018-05-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=313195, encodeId=4b1431319599, content=了解一下.谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2019/12/23/2f51002e1349ccda5be11c1eea1e1e60.jpg, createdBy=a22097948, createdName=天地飞扬, createdTime=Tue May 08 15:46:22 CST 2018, time=2018-05-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=313186, encodeId=a6cd31318645, content=创伤性脑损伤(TBI)发病率较高.特别是军人群体.先前的研究发现中重度TBI导致痴呆风险增加.但痴呆与轻微TBI.特别是非意识丧失性(LOC)轻微TBI之间的关系尚不清楚.近日研究人员在退伍军人群体中考察了TBI程度.LOC与痴呆之间的关系., beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7cJ6ejWUr2nIia8qOvAKNdLHr32Df6G8iaoaOx6pHaoiacwp26DaslxZHCGbibZhhCGven4rvmWP60GahtzgFjgCjR/0, createdBy=6b111703011, createdName=有备才能无患, createdTime=Tue May 08 15:24:26 CST 2018, time=2018-05-08, status=1, ipAttribution=)]
  7. 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encryptionId=df8950505a2, topicName=微创)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=644e456, createdName=vera_1203, createdTime=Thu May 10 05:19:00 CST 2018, time=2018-05-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1335212, encodeId=38b013352126a, content=<a href='/topic/show?id=e7cc32022c7' target=_blank style='color:#2F92EE;'>#创伤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=32022, encryptionId=e7cc32022c7, topicName=创伤)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=aa5a2500103, createdName=ms920641618706883, createdTime=Thu May 10 05:19:00 CST 2018, time=2018-05-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1397535, encodeId=01ae139e535d5, content=<a href='/topic/show?id=8bee565436d' target=_blank style='color:#2F92EE;'>#损伤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=56543, encryptionId=8bee565436d, topicName=损伤)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83eoNX3lUOlDKGBUEPNwZx0nibmdcFyeibnX4WMhUSCU2REpGRWtSmnT2CCs0dA5waxvJknYDxwtYnIcQ/132, createdBy=294e2500218, createdName=ms3046638856685384, createdTime=Thu May 10 05:19:00 CST 2018, time=2018-05-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=313481, encodeId=19c531348188, content=学习了.长知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Wed May 09 10:48:53 CST 2018, time=2018-05-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=313197, encodeId=270531319e57, content=了解一下.谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=88, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2019/12/23/2f51002e1349ccda5be11c1eea1e1e60.jpg, createdBy=a22097948, createdName=天地飞扬, createdTime=Tue May 08 15:46:45 CST 2018, time=2018-05-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=313195, encodeId=4b1431319599, content=了解一下.谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2019/12/23/2f51002e1349ccda5be11c1eea1e1e60.jpg, createdBy=a22097948, createdName=天地飞扬, createdTime=Tue May 08 15:46:22 CST 2018, time=2018-05-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=313186, encodeId=a6cd31318645, content=创伤性脑损伤(TBI)发病率较高.特别是军人群体.先前的研究发现中重度TBI导致痴呆风险增加.但痴呆与轻微TBI.特别是非意识丧失性(LOC)轻微TBI之间的关系尚不清楚.近日研究人员在退伍军人群体中考察了TBI程度.LOC与痴呆之间的关系., beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7cJ6ejWUr2nIia8qOvAKNdLHr32Df6G8iaoaOx6pHaoiacwp26DaslxZHCGbibZhhCGven4rvmWP60GahtzgFjgCjR/0, createdBy=6b111703011, createdName=有备才能无患, createdTime=Tue May 08 15:24:26 CST 2018, time=2018-05-08, status=1, ipAttribution=)]
    2018-05-09 1ddf0692m34(暂无匿称)

    学习了.长知识

    0

  8. 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channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=56543, encryptionId=8bee565436d, topicName=损伤)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83eoNX3lUOlDKGBUEPNwZx0nibmdcFyeibnX4WMhUSCU2REpGRWtSmnT2CCs0dA5waxvJknYDxwtYnIcQ/132, createdBy=294e2500218, createdName=ms3046638856685384, createdTime=Thu May 10 05:19:00 CST 2018, time=2018-05-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=313481, encodeId=19c531348188, content=学习了.长知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Wed May 09 10:48:53 CST 2018, time=2018-05-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=313197, encodeId=270531319e57, content=了解一下.谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=88, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2019/12/23/2f51002e1349ccda5be11c1eea1e1e60.jpg, createdBy=a22097948, createdName=天地飞扬, createdTime=Tue May 08 15:46:45 CST 2018, time=2018-05-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=313195, encodeId=4b1431319599, content=了解一下.谢谢分享!, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2019/12/23/2f51002e1349ccda5be11c1eea1e1e60.jpg, createdBy=a22097948, createdName=天地飞扬, createdTime=Tue May 08 15:46:22 CST 2018, time=2018-05-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=313186, encodeId=a6cd31318645, content=创伤性脑损伤(TBI)发病率较高.特别是军人群体.先前的研究发现中重度TBI导致痴呆风险增加.但痴呆与轻微TBI.特别是非意识丧失性(LOC)轻微TBI之间的关系尚不清楚.近日研究人员在退伍军人群体中考察了TBI程度.LOC与痴呆之间的关系., beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7cJ6ejWUr2nIia8qOvAKNdLHr32Df6G8iaoaOx6pHaoiacwp26DaslxZHCGbibZhhCGven4rvmWP60GahtzgFjgCjR/0, createdBy=6b111703011, createdName=有备才能无患, createdTime=Tue May 08 15:24:26 CST 2018, time=2018-05-08, status=1, ipAttribution=)]
    2018-05-08 天地飞扬

    了解一下.谢谢分享!

    0

  9. 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channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=56543, encryptionId=8bee565436d, topicName=损伤)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83eoNX3lUOlDKGBUEPNwZx0nibmdcFyeibnX4WMhUSCU2REpGRWtSmnT2CCs0dA5waxvJknYDxwtYnIcQ/132, createdBy=294e2500218, createdName=ms3046638856685384, createdTime=Thu May 10 05:19:00 CST 2018, time=2018-05-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=313481, encodeId=19c531348188, content=学习了.长知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Wed May 09 10:48:53 CST 2018, time=2018-05-09, status=1, 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status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=313186, encodeId=a6cd31318645, content=创伤性脑损伤(TBI)发病率较高.特别是军人群体.先前的研究发现中重度TBI导致痴呆风险增加.但痴呆与轻微TBI.特别是非意识丧失性(LOC)轻微TBI之间的关系尚不清楚.近日研究人员在退伍军人群体中考察了TBI程度.LOC与痴呆之间的关系., beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7cJ6ejWUr2nIia8qOvAKNdLHr32Df6G8iaoaOx6pHaoiacwp26DaslxZHCGbibZhhCGven4rvmWP60GahtzgFjgCjR/0, createdBy=6b111703011, createdName=有备才能无患, createdTime=Tue May 08 15:24:26 CST 2018, time=2018-05-08, status=1, ipAttribution=)]
    2018-05-08 天地飞扬

    了解一下.谢谢分享!

    0

  10. 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status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=313186, encodeId=a6cd31318645, content=创伤性脑损伤(TBI)发病率较高.特别是军人群体.先前的研究发现中重度TBI导致痴呆风险增加.但痴呆与轻微TBI.特别是非意识丧失性(LOC)轻微TBI之间的关系尚不清楚.近日研究人员在退伍军人群体中考察了TBI程度.LOC与痴呆之间的关系., beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7cJ6ejWUr2nIia8qOvAKNdLHr32Df6G8iaoaOx6pHaoiacwp26DaslxZHCGbibZhhCGven4rvmWP60GahtzgFjgCjR/0, createdBy=6b111703011, createdName=有备才能无患, createdTime=Tue May 08 15:24:26 CST 2018, time=2018-05-08, status=1, ipAttribution=)]
    2018-05-08 有备才能无患

    创伤性脑损伤(TBI)发病率较高.特别是军人群体.先前的研究发现中重度TBI导致痴呆风险增加.但痴呆与轻微TBI.特别是非意识丧失性(LOC)轻微TBI之间的关系尚不清楚.近日研究人员在退伍军人群体中考察了TBI程度.LOC与痴呆之间的关系.

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