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Advanced Science：青光眼的新型疗法，无需药物或手术

2020-12-10 MedSci原创 MedSci原创

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眼压病理性升高是青光眼视神经损害的主要危险因素之一，降低眼压被证实的有效的治疗方法。目前，临床上主要治疗方式为滴眼剂以及外科手术等，但这些治疗方式疗效有限。近日，研究人员开发了一种非药物，非手术，长效

眼压病理性升高是青光眼视神经损害的主要危险因素之一，降低眼压被证实的有效的治疗方法。目前，临床上主要治疗方式为滴眼剂以及外科手术等，但这些治疗方式疗效有限。近日，研究人员开发了一种非药物，非手术，长效的治疗青光眼的新方法以控制眼压。研究结果发表在Advanced Science杂志上。

这种新的治疗方式是使用一根微小的空心针将一种天然聚合物制剂注射到眼表下方的脉络膜上腔 (SCS) 的结构中。在眼睛内部，该材料发生化学交联形成水凝胶，在SCS中打开一条通道，让房水通过另一个途径排出，从而降低眼压。

脉络膜上的水凝胶注射方案和研究设计概述

在这项研究中，研究人员通过动物模型进行试验，结果发现，向SCS注射以透明质酸(HA)为基础的水凝胶可降低兔眼眼压1个月以上，优化凝胶配方后可使眼压降低长达4个月。通过临床眼科检查的安全性评估表明，耐受性良好。组织病理学显示注射部位有轻微出血和纤维化。研究人员表示，随着技术的发展，后续有望将效果维持长达六个月。

脉络膜上水凝胶注射液对兔眼眼压（IOP）的影响

进一步分析表明，眼压降低与SCS扩张有很强的相关性。治疗眼和未治疗眼的压力依赖性流出的常规途径没有差异。

总之，SCS扩容与原位成形水凝胶可使眼压降低的时间延长，用于治疗眼高血压和青光眼，无需药物或手术。同时，该方法可以重复进行而不会伤害眼睛。在进入人体试验之前，该程序还必须在其他动物身上进行测试。

原始出处

J. Jeremy Chae et al, Drug‐Free, Nonsurgical Reduction of Intraocular Pressure for Four Months after Suprachoroidal Injection of Hyaluronic Acid Hydrogel, Advanced Science 2020. 

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    2022-01-03 ms3000000727805956

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    2021-04-30 MedSciZeng

    #Science#点击进入话题查看更多相关文章 或评论时插入话题加入讨论

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createdAvatar=https://img.medsci.cn/20201118/68d39549b17540d1a860b9d81ab34778/2975f9542e0649e098b2897635114ff4.jpg, createdBy=8faa5429820, createdName=ms1000000534935938, createdTime=Wed Dec 23 11:37:21 CST 2020, time=2020-12-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1376222, encodeId=61b413e622277, content=<a href='/topic/show?id=2949159989d' target=_blank style='color:#2F92EE;'>#SCIE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15998, encryptionId=2949159989d, topicName=SCIE)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=395f25, createdName=爆笑小医, createdTime=Sat Dec 12 05:26:14 CST 2020, time=2020-12-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=907025, encodeId=453990e025b5, content=厉害, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210405/8cca360e910e4e4abbad67324b2cf9ef/37fef780c17a4da7b5506ea9971b725e.jpg, createdBy=91fa5404020, createdName=暂0e4516bm, createdTime=Fri Dec 11 12:46:39 CST 2020, time=2020-12-11, status=1, ipAttribution=)]
    2021-09-06 smartjoy

    #新型疗法#

    0

  5. 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createdName=ms9000000303164655, createdTime=Fri Feb 19 17:12:36 CST 2021, time=2021-02-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=906708, encodeId=de60906e08a5, content=青光眼患者**，希望尽快进入临床, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=1, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220301/6252e946e5ef413b86dc0f7d1f73b6db/9a7e8c88a38e487b8da4968a67bbd261.png, createdBy=b9f692910, createdName=rayms, createdTime=Thu Dec 10 14:57:40 CST 2020, time=2020-12-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=910317, encodeId=12cb91031e39, content=思路可以, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, 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topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210405/8cca360e910e4e4abbad67324b2cf9ef/37fef780c17a4da7b5506ea9971b725e.jpg, createdBy=91fa5404020, createdName=暂0e4516bm, createdTime=Fri Dec 11 12:46:39 CST 2020, time=2020-12-11, status=1, ipAttribution=)]
    2021-03-17 330911029

    厉害

    0

  6. 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createdName=ms9000000303164655, createdTime=Fri Feb 19 17:12:36 CST 2021, time=2021-02-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=906708, encodeId=de60906e08a5, content=青光眼患者**，希望尽快进入临床, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=1, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220301/6252e946e5ef413b86dc0f7d1f73b6db/9a7e8c88a38e487b8da4968a67bbd261.png, createdBy=b9f692910, createdName=rayms, createdTime=Thu Dec 10 14:57:40 CST 2020, time=2020-12-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=910317, encodeId=12cb91031e39, content=思路可以, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, 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topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210405/8cca360e910e4e4abbad67324b2cf9ef/37fef780c17a4da7b5506ea9971b725e.jpg, createdBy=91fa5404020, createdName=暂0e4516bm, createdTime=Fri Dec 11 12:46:39 CST 2020, time=2020-12-11, status=1, ipAttribution=)]
    2021-02-19 ms9000000303164655

    什么时候用到人身上阿

    0

  7. 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topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210405/8cca360e910e4e4abbad67324b2cf9ef/37fef780c17a4da7b5506ea9971b725e.jpg, createdBy=91fa5404020, createdName=暂0e4516bm, createdTime=Fri Dec 11 12:46:39 CST 2020, time=2020-12-11, status=1, ipAttribution=)]
    2020-12-10 rayms

    青光眼患者**，希望尽快进入临床

    1

    展开1条回复
  8. 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createdName=ms9000000303164655, createdTime=Fri Feb 19 17:12:36 CST 2021, time=2021-02-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=906708, encodeId=de60906e08a5, content=青光眼患者**，希望尽快进入临床, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=1, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220301/6252e946e5ef413b86dc0f7d1f73b6db/9a7e8c88a38e487b8da4968a67bbd261.png, createdBy=b9f692910, createdName=rayms, createdTime=Thu Dec 10 14:57:40 CST 2020, time=2020-12-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=910317, encodeId=12cb91031e39, content=思路可以, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, 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topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210405/8cca360e910e4e4abbad67324b2cf9ef/37fef780c17a4da7b5506ea9971b725e.jpg, createdBy=91fa5404020, createdName=暂0e4516bm, createdTime=Fri Dec 11 12:46:39 CST 2020, time=2020-12-11, status=1, ipAttribution=)]
    2020-12-23 ms1000000534935938

    思路可以

    0

  9. 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createdName=ms9000000303164655, createdTime=Fri Feb 19 17:12:36 CST 2021, time=2021-02-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=906708, encodeId=de60906e08a5, content=青光眼患者**，希望尽快进入临床, beContent=null, objectType=article, channel=null, level=null, likeNumber=96, replyNumber=1, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220301/6252e946e5ef413b86dc0f7d1f73b6db/9a7e8c88a38e487b8da4968a67bbd261.png, createdBy=b9f692910, createdName=rayms, createdTime=Thu Dec 10 14:57:40 CST 2020, time=2020-12-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=910317, encodeId=12cb91031e39, content=思路可以, beContent=null, objectType=article, channel=null, level=null, likeNumber=71, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, 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topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210405/8cca360e910e4e4abbad67324b2cf9ef/37fef780c17a4da7b5506ea9971b725e.jpg, createdBy=91fa5404020, createdName=暂0e4516bm, createdTime=Fri Dec 11 12:46:39 CST 2020, time=2020-12-11, status=1, ipAttribution=)]
    2020-12-12 爆笑小医

    #SCIE#

    0

  10. 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topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20210405/8cca360e910e4e4abbad67324b2cf9ef/37fef780c17a4da7b5506ea9971b725e.jpg, createdBy=91fa5404020, createdName=暂0e4516bm, createdTime=Fri Dec 11 12:46:39 CST 2020, time=2020-12-11, status=1, ipAttribution=)]
    2020-12-11 暂0e4516bm

    厉害

    0

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