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Biomaterials：可控制和持续递送siRNA/NP的水凝胶可有效加速骨折愈合

2018-09-27 MedSci MedSci原创

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尽管具有巨大的潜力，但是siRNA的有效递送仍然是限制其广泛使用的最大障碍。由于对RNase降解的敏感性，低细胞摄取和组织特异性定位差，siRNA的递送存在限制。在这里，我们报告了克服这些困难的混合纳米粒子（NP）/水凝胶系统。 水凝胶通过控制释放包埋的siRNA/NPs复合物提供局部和持续递送，而NPs保护并实现siRNA的有效细胞溶质积累。为了证明治疗功效，将与NP复合的含WW结构域的E

尽管具有巨大的潜力，但是siRNA的有效递送仍然是限制其广泛使用的最大障碍。由于对RNase降解的敏感性，低细胞摄取和组织特异性定位差，siRNA的递送存在限制。在这里，我们报告了克服这些困难的混合纳米粒子（NP）/水凝胶系统。

水凝胶通过控制释放包埋的siRNA/NPs复合物提供局部和持续递送，而NPs保护并实现siRNA的有效细胞溶质积累。为了证明治疗功效，将与NP复合的含WW结构域的E3遍在蛋白连接酶1（Wwp1）的再生siRNA包埋在基于聚（乙二醇）（PEG）的水凝胶中，并植入小鼠骨干股骨骨折的部位。

结果显示，水凝胶的定位和在骨折裂缝中控制释放siRNA/NPs 28天，这是发生骨折愈合的时间范围。与未处理的对照相比，水凝胶的siRNA/NPs持续递送导致骨折愈伤组织处Wwp1的明显沉默。siRNA/NPs水凝胶处理的骨折表现出加速的骨形成和生物力学强度的显著增加。

这种NP /水凝胶siRNA递送系统具有突出的治疗前景，可增强骨折愈合。由于siRNA的结构相似性，用于体内siRNA递送的水凝胶平台的开发在整形外科及其他方面具有无数的治疗可能性。

原始出处：

Yuchen Wang, Dominic W. Malcolm, et al., Controlled and sustained delivery of siRNA/NPs from hydrogels expedites bone fracture healing. Biomaterials. 2017 Sep; 139: 127–138.

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    2018-12-29 zhangyxzsh

    #Biomaterials#

    0

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    2018-10-13 HinsMax

    #骨折愈合#

    0

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    2019-06-30 sunylz

    #Bio#

    0

  4. 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2018, time=2018-09-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=346848, encodeId=6f6b3468481f, content=学习了，谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7c592194322, createdName=1209e435m98(暂无昵称), createdTime=Thu Sep 27 01:24:41 CST 2018, time=2018-09-27, status=1, ipAttribution=)]
    2018-09-28 tastas

    #水凝胶#

    0

  5. 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2018, time=2018-09-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=346848, encodeId=6f6b3468481f, content=学习了，谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7c592194322, createdName=1209e435m98(暂无昵称), createdTime=Thu Sep 27 01:24:41 CST 2018, time=2018-09-27, status=1, ipAttribution=)]
    2018-09-28 lishizhe

    #凝胶#

    0

  6. 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objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=16332, encryptionId=c87e16332da, topicName=siRNA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=271114029857, createdName=12498ebem23暂无昵称, createdTime=Fri Sep 28 16:18:00 CST 2018, time=2018-09-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=346892, encodeId=6fc13468920d, content=感谢小编为我们准备了如此丰盛的精神大餐，同时也向作者致谢！认真学习了，点赞！, beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Thu Sep 27 09:15:09 CST 2018, time=2018-09-27, status=1, ipAttribution=), 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2018, time=2018-09-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=346848, encodeId=6f6b3468481f, content=学习了，谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7c592194322, createdName=1209e435m98(暂无昵称), createdTime=Thu Sep 27 01:24:41 CST 2018, time=2018-09-27, status=1, ipAttribution=)]
    2018-09-28 12498ebem23暂无昵称

    #siRNA#

    0

  7. 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2018, time=2018-09-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=346848, encodeId=6f6b3468481f, content=学习了，谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7c592194322, createdName=1209e435m98(暂无昵称), createdTime=Thu Sep 27 01:24:41 CST 2018, time=2018-09-27, status=1, ipAttribution=)]
    2018-09-27 ylzr123

    感谢小编为我们准备了如此丰盛的精神大餐，同时也向作者致谢！认真学习了，点赞！

    0

  8. 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2018, time=2018-09-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=346848, encodeId=6f6b3468481f, content=学习了，谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7c592194322, createdName=1209e435m98(暂无昵称), createdTime=Thu Sep 27 01:24:41 CST 2018, time=2018-09-27, status=1, ipAttribution=)]
    2018-09-27 明月清辉

    谢谢分享，学习了

    0

  9. 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2018, time=2018-09-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=346848, encodeId=6f6b3468481f, content=学习了，谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7c592194322, createdName=1209e435m98(暂无昵称), createdTime=Thu Sep 27 01:24:41 CST 2018, time=2018-09-27, status=1, ipAttribution=)]
    2018-09-27 liumin1987

    嗯嗯，学习了。

    0

  10. 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2018, time=2018-09-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=346848, encodeId=6f6b3468481f, content=学习了，谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=66, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7c592194322, createdName=1209e435m98(暂无昵称), createdTime=Thu Sep 27 01:24:41 CST 2018, time=2018-09-27, status=1, ipAttribution=)]
    2018-09-27 1209e435m98(暂无昵称)

    学习了，谢谢分享

    0

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