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Int J Nanomed：GO-Ag-Ti复合材料具有优异的抗菌和成骨性能

2019-11-28 不详 网络

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钛（Ti）植入物的表面改性已得到广泛研究，以获得很好的生物相容性和抗菌活性，尤其是防止植入物相关的感染。在这项研究中，通过氧化石墨烯（GO）薄膜和银（Ag）纳米粒子通过电镀和紫外线还原方法对Ti衬底表面进行了改性，从而达到了这一目的。表征了钛板表面GO和Ag负载的微观结构，分布，数量和光谱峰。 结果显示，GO-Ag-Ti多相纳米复合材料具有优异的抗菌能力和抗粘附性能。随后，监测在Ti样品表面上孵育

钛（Ti）植入物的表面改性已得到广泛研究，以获得很好的生物相容性和抗菌活性，尤其是防止植入物相关的感染。

在这项研究中，通过氧化石墨烯（GO）薄膜和银（Ag）纳米粒子通过电镀和紫外线还原方法对Ti衬底表面进行了改性，从而达到了这一目的。表征了钛板表面GO和Ag负载的微观结构，分布，数量和光谱峰。

结果显示，GO-Ag-Ti多相纳米复合材料具有优异的抗菌能力和抗粘附性能。随后，监测在Ti样品表面上孵育的细菌的形态，膜完整性，凋亡和相关基因表达，以揭示其杀菌机理。此外，研究了掺有GO薄膜和Ag纳米粒子的Ti衬底的细胞毒性。

综上所述，具有出色抗菌性能的GO-Ag-Ti复合材料构型将为将来在体外和体内研究骨整合提供基础。

原始出处：

Jin J, Zhang L, et al., Ti-GO-Ag nanocomposite: the effect of content level on the antimicrobial activity and cytotoxicity. Int J Nanomedicine. 2017 Jun 7;12:4209-4224. doi: 10.2147/IJN.S134843. eCollection 2017.

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    2020-02-01 hunizi005

    #GO-Ag#

    0

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    2020-08-27 ms4964546379600229

    #复合材料#

    0

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    2019-11-30 ms7899726347904398

    #抗菌#

    0

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    2019-11-30 zhaojie88

    #成骨#

    0

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    2019-11-30 ms3994565386320060

    #Med#

    0