Stroke:脑出血后严重缺血性和出血性事件的五年风险

2019-04-16 xing.T 网络

由此可见,ICH幸存者发生颅内和颅外血管事件风险升高。缺血性或出血性风险特征根据ICH位置而变化,在深部ICH中具有更强的缺血性事件风险。针对ICH的部位,二级预防不仅应针对脑出血复发,还应针对脑外血管事件。

近日,血管疾病领域权威杂志Stroke上发表了一篇研究文章,该研究旨在确定脑出血(ICH)幸存者中大血管事件的发生率和预测因子。

研究人员对来自法国里尔的颅内出血预后队列中的自发性ICH患者进行了一项前瞻性观察性队列研究。研究人员根据ICH位置分析了30天内存活患者的长期(颅内和颅外,缺血和出血)血管事件的发生率和预测因子,并进行了预先指定的亚组分析。研究人员进行了多变量分析(竞争风险分析,在随访期间将死亡视为竞争事件)。

从2004年11月至2009年3月期间入组的560例自发性ICH患者中,研究人员纳入了310例患者(中位年龄为70岁)。在ICH后5年,82名患者出现至少1例大血管事件,其发病率为20.0%(95%CI为15.7-24.7)。在整个队列中,缺血事件比出血事件更频繁。然而,根据ICH位置,发病率明显不同:深部ICH与未来缺血事件相关(亚风险比为1.85; 95%CI为1.01-3.40),而脑叶ICH与出血事件相关(亚风险比为2.38; 95%CI为1.17-4.86)。在深部ICH中,5年时缺血事件的发生率比出血事件的发生率高6倍。 

由此可见,ICH幸存者发生颅内和颅外血管事件风险升高。缺血性或出血性风险特征根据ICH位置而变化,在深部ICH中具有更强的缺血性事件风险。针对ICH的部位,二级预防不仅应针对脑出血复发,还应针对脑外血管事件。 

原始出处:

Barbara Casolla.et al.Five-Year Risk of Major Ischemic and Hemorrhagic Events After Intracerebral Hemorrhage.stroke.2019.https://www.ahajournals.org/doi/10.1161/STROKEAHA.118.024449

本文系梅斯医学(MedSci)原创编译整理,转载需授权!

版权声明:
本网站所有内容来源注明为“梅斯医学”或“MedSci原创”的文字、图片和音视频资料,版权均属于梅斯医学所有。非经授权,任何媒体、网站或个人不得转载,授权转载时须注明来源为“梅斯医学”。其它来源的文章系转载文章,或“梅斯号”自媒体发布的文章,仅系出于传递更多信息之目的,本站仅负责审核内容合规,其内容不代表本站立场,本站不负责内容的准确性和版权。如果存在侵权、或不希望被转载的媒体或个人可与我们联系,我们将立即进行删除处理。
在此留言
评论区 (5)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=1893166, encodeId=2db7189316603, content=<a href='/topic/show?id=c738e93521f' target=_blank style='color:#2F92EE;'>#缺血性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79352, encryptionId=c738e93521f, topicName=缺血性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=66ec123, createdName=guihongzh, createdTime=Sat Jul 06 21:49:00 CST 2019, time=2019-07-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2039579, encodeId=91df20395e9ab, content=<a href='/topic/show?id=ea4024183ac' target=_blank style='color:#2F92EE;'>#五年风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=24183, encryptionId=ea4024183ac, topicName=五年风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8f0715, createdName=showtest, createdTime=Sat Nov 23 21:49:00 CST 2019, time=2019-11-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2046337, encodeId=e349204633eea, content=<a href='/topic/show?id=5da531455b9' target=_blank style='color:#2F92EE;'>#出血性事件#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=31455, encryptionId=5da531455b9, topicName=出血性事件)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7460166, createdName=zhang92560, createdTime=Sat Jul 20 13:49:00 CST 2019, time=2019-07-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=364816, encodeId=0db536481668, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=82311653708, createdName=医者仁心5538, createdTime=Wed Apr 17 22:11:55 CST 2019, time=2019-04-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=364752, encodeId=3dc1364e52b7, content=学习了,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Tue Apr 16 19:22:45 CST 2019, time=2019-04-16, status=1, ipAttribution=)]
  2. [GetPortalCommentsPageByObjectIdResponse(id=1893166, encodeId=2db7189316603, content=<a href='/topic/show?id=c738e93521f' target=_blank style='color:#2F92EE;'>#缺血性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79352, encryptionId=c738e93521f, topicName=缺血性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=66ec123, createdName=guihongzh, createdTime=Sat Jul 06 21:49:00 CST 2019, time=2019-07-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2039579, encodeId=91df20395e9ab, content=<a href='/topic/show?id=ea4024183ac' target=_blank style='color:#2F92EE;'>#五年风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=24183, encryptionId=ea4024183ac, topicName=五年风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8f0715, createdName=showtest, createdTime=Sat Nov 23 21:49:00 CST 2019, time=2019-11-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2046337, encodeId=e349204633eea, content=<a href='/topic/show?id=5da531455b9' target=_blank style='color:#2F92EE;'>#出血性事件#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=31455, encryptionId=5da531455b9, topicName=出血性事件)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7460166, createdName=zhang92560, createdTime=Sat Jul 20 13:49:00 CST 2019, time=2019-07-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=364816, encodeId=0db536481668, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=82311653708, createdName=医者仁心5538, createdTime=Wed Apr 17 22:11:55 CST 2019, time=2019-04-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=364752, encodeId=3dc1364e52b7, content=学习了,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Tue Apr 16 19:22:45 CST 2019, time=2019-04-16, status=1, ipAttribution=)]
  3. [GetPortalCommentsPageByObjectIdResponse(id=1893166, encodeId=2db7189316603, content=<a href='/topic/show?id=c738e93521f' target=_blank style='color:#2F92EE;'>#缺血性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79352, encryptionId=c738e93521f, topicName=缺血性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=66ec123, createdName=guihongzh, createdTime=Sat Jul 06 21:49:00 CST 2019, time=2019-07-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2039579, encodeId=91df20395e9ab, content=<a href='/topic/show?id=ea4024183ac' target=_blank style='color:#2F92EE;'>#五年风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=24183, encryptionId=ea4024183ac, topicName=五年风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8f0715, createdName=showtest, createdTime=Sat Nov 23 21:49:00 CST 2019, time=2019-11-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2046337, encodeId=e349204633eea, content=<a href='/topic/show?id=5da531455b9' target=_blank style='color:#2F92EE;'>#出血性事件#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=31455, encryptionId=5da531455b9, topicName=出血性事件)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7460166, createdName=zhang92560, createdTime=Sat Jul 20 13:49:00 CST 2019, time=2019-07-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=364816, encodeId=0db536481668, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=82311653708, createdName=医者仁心5538, createdTime=Wed Apr 17 22:11:55 CST 2019, time=2019-04-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=364752, encodeId=3dc1364e52b7, content=学习了,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Tue Apr 16 19:22:45 CST 2019, time=2019-04-16, status=1, ipAttribution=)]
  4. [GetPortalCommentsPageByObjectIdResponse(id=1893166, encodeId=2db7189316603, content=<a href='/topic/show?id=c738e93521f' target=_blank style='color:#2F92EE;'>#缺血性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79352, encryptionId=c738e93521f, topicName=缺血性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=66ec123, createdName=guihongzh, createdTime=Sat Jul 06 21:49:00 CST 2019, time=2019-07-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2039579, encodeId=91df20395e9ab, content=<a href='/topic/show?id=ea4024183ac' target=_blank style='color:#2F92EE;'>#五年风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=24183, encryptionId=ea4024183ac, topicName=五年风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8f0715, createdName=showtest, createdTime=Sat Nov 23 21:49:00 CST 2019, time=2019-11-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2046337, encodeId=e349204633eea, content=<a href='/topic/show?id=5da531455b9' target=_blank style='color:#2F92EE;'>#出血性事件#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=31455, encryptionId=5da531455b9, topicName=出血性事件)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7460166, createdName=zhang92560, createdTime=Sat Jul 20 13:49:00 CST 2019, time=2019-07-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=364816, encodeId=0db536481668, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=82311653708, createdName=医者仁心5538, createdTime=Wed Apr 17 22:11:55 CST 2019, time=2019-04-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=364752, encodeId=3dc1364e52b7, content=学习了,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Tue Apr 16 19:22:45 CST 2019, time=2019-04-16, status=1, ipAttribution=)]
    2019-04-17 医者仁心5538

    学习了

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1893166, encodeId=2db7189316603, content=<a href='/topic/show?id=c738e93521f' target=_blank style='color:#2F92EE;'>#缺血性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79352, encryptionId=c738e93521f, topicName=缺血性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=66ec123, createdName=guihongzh, createdTime=Sat Jul 06 21:49:00 CST 2019, time=2019-07-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2039579, encodeId=91df20395e9ab, content=<a href='/topic/show?id=ea4024183ac' target=_blank style='color:#2F92EE;'>#五年风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=24183, encryptionId=ea4024183ac, topicName=五年风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=8f0715, createdName=showtest, createdTime=Sat Nov 23 21:49:00 CST 2019, time=2019-11-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2046337, encodeId=e349204633eea, content=<a href='/topic/show?id=5da531455b9' target=_blank style='color:#2F92EE;'>#出血性事件#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=31455, encryptionId=5da531455b9, topicName=出血性事件)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7460166, createdName=zhang92560, createdTime=Sat Jul 20 13:49:00 CST 2019, time=2019-07-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=364816, encodeId=0db536481668, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=82311653708, createdName=医者仁心5538, createdTime=Wed Apr 17 22:11:55 CST 2019, time=2019-04-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=364752, encodeId=3dc1364e52b7, content=学习了,谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Tue Apr 16 19:22:45 CST 2019, time=2019-04-16, status=1, ipAttribution=)]
    2019-04-16 1ddf0692m34(暂无匿称)

    学习了,谢谢分享

    0

相关资讯

1例脑出血患者住院治疗期间突发吉兰-巴雷综合征

患者,女,66岁。因:“右侧肢体无力伴言语不清1h”入院。患者入院前约1h无明显诱因出现左侧肢体活动无力,伴言语不清,感头痛及头部不适,无恶心、呕吐,无肢体抽搐及大小便失禁。

Lancet:适度饮酒并不能降低心血管疾病风险!

squamous一直以来,很多研究表明适度摄入酒精,相比禁酒和大量饮酒,与心血管风险降低相关。东亚的研究可帮助明确这种相关性是否存在因果关系,因为两个常见的遗传突变可明显影响酒精的摄入模式。研究人员通过这两个突变评估心血管风险与基因型预测的平均酒精摄入在男性中的相关性,并与在女性中的发现进行对比。2004年6月25日-2008年7月15日,研究人员从中国的10个地区招募了512715位成年人,记录

Neurology:深部+皮层 ICH/微出血的病因是什么?

一项最近的研究显示混合 ICH被认为更加类似于 HTN-ICH,而不是 CAA 相关 ICH(CAA-ICH)。这很可能是因为这些患者都具有 HTN-ICH 微血管病特征,这主要是血管病危险因素所致。然而,这个假说尚未被神经病理分析或技术验乞,比如活体检测血管淀粉沉积。

Lancet:微创导管溶栓对中重度脑出血患者预后的影响

研究认为,微创导管溶栓不能显著提高中重度脑出血患者1年预后

脑出血术后病人出现粉红色泡沫痰了!这锅谁背?

62岁的女性,因“脑出血去骨瓣减压术后”转入ICU。

Lancet Neurol:甲磺酸去铁胺不能改善脑出血患者预后

甲磺酸去铁胺用于幕上性脑出血是安全的,但其不能改善患者90天预后