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Nat Commun：VEGF-MPs可提高血管生成细胞治疗缺血性疾病的效果

2017-10-08 MedSci MedSci原创

VEGF-MPs缺血性疾病
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目前几种基于细胞的疗法在治疗缺血性疾病的应用方面正处于临床前和临床的评估过程中。移植细胞较差的的存活率和血管植入率使得细胞疗法主要通过有时限的旁分泌作用进行工作。尽管在过去十年中研究人员已经研发了几种方法，包括使用可溶性血管内皮生长因子（sVEGF）-VEGF165，以增强细胞存活率，但这些方法的效力有限。本研究中，研究人员研发了一种基于VEGF固定化微粒（VEGF-MPs）的促生存的方法。在脐带

目前几种基于细胞的疗法在治疗缺血性疾病的应用方面正处于临床前和临床的评估过程中。移植细胞较差的的存活率和血管植入率使得细胞疗法主要通过有时限的旁分泌作用进行工作。尽管在过去十年中研究人员已经研发了几种方法，包括使用可溶性血管内皮生长因子（sVEGF）-VEGF165，以增强细胞存活率，但这些方法的效力有限。

本研究中，研究人员研发了一种基于VEGF固定化微粒（VEGF-MPs）的促生存的方法。在脐带血衍生的晚期内生内皮祖细胞（OEPC）中VEGF-MPs可延长VEGFR-2和Akt磷酸化。在体内，含有VEGF-MPs的OEPC聚集体的存活率高于sVEGF处理的那些聚集体的存活率。另外VEGF-MPs可减少OEPCs中的miR-17表达，从而增加其靶基因CDKN1A和ZNF652的表达。通过抑制体内miR-17的表达从而改善OEPC的治疗效果。

总体而言，该研究提供了一种可提高促血管生成细胞治疗缺血性疾病疗效的方法。

原始出处：

Sezin Aday, Janet Zoldan, et al., Synthetic microparticles conjugated with VEGF165 improve the survival of endothelial progenitor cells via microRNA-17 inhibition. Nat Commun. 2017; 8: 747. Published online 2017 Sep 29. doi: 10.1038/s41467-017-00746-7

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    2017-11-19 liuli5079

    #COMMUN#

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    2018-02-07 124987e8m07暂无昵称

    #MPS#

    0

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    2018-04-23 guihongzh

    #缺血性#

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    2017-12-11 liye789132251

    #Nat#

    0

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    2017-10-10 fanweitanzhen

    #VEGF#

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=2087142, encodeId=86b8208e1427b, content=<a href='/topic/show?id=490750196b' target=_blank style='color:#2F92EE;'>#COMMUN#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5019, encryptionId=490750196b, topicName=COMMUN)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7931272, createdName=liuli5079, createdTime=Sun Nov 19 12:46:00 CST 2017, time=2017-11-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1984947, encodeId=b22a198494e4f, content=<a href='/topic/show?id=d3811218054' target=_blank style='color:#2F92EE;'>#MPS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12180, encryptionId=d3811218054, topicName=MPS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=101c2500074, createdName=124987e8m07暂无昵称, createdTime=Wed Feb 07 23:46:00 CST 2018, time=2018-02-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1892951, encodeId=7b72189295117, content=<a href='/topic/show?id=c738e93521f' target=_blank style='color:#2F92EE;'>#缺血性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=17, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=79352, encryptionId=c738e93521f, topicName=缺血性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=66ec123, createdName=guihongzh, createdTime=Mon Apr 23 09:46:00 CST 2018, time=2018-04-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1882496, encodeId=866c1882496c7, content=<a href='/topic/show?id=3b2112532d8' target=_blank style='color:#2F92EE;'>#Nat#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12532, encryptionId=3b2112532d8, topicName=Nat)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e6f107, createdName=liye789132251, createdTime=Mon Dec 11 11:46:00 CST 2017, time=2017-12-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1368490, encodeId=e5e51368490a3, content=<a href='/topic/show?id=25aa1833e88' target=_blank style='color:#2F92EE;'>#VEGF#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=18337, encryptionId=25aa1833e88, topicName=VEGF)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=80ca273, createdName=fanweitanzhen, createdTime=Tue Oct 10 08:46:00 CST 2017, time=2017-10-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=251424, encodeId=6cd825142436, content=非常好的文章.学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7LIiaRZTzJ3SEfiauCzTMPW7YvPPYLNJBXG9oh6Al1icq2VQQkIHWxqXehcicTS62YKJVBhxeth3wggw/0, createdBy=7ce01621306, createdName=天涯183, createdTime=Sun Oct 08 23:56:34 CST 2017, time=2017-10-08, status=1, ipAttribution=)]
    2017-10-08 天涯183

    非常好的文章.学习了

    0