君实生物重组全人源抗SARS-CoV-2单克隆抗体注射液进展良好

2020-10-08 亿欧亿欧

君实生物公布其重组全人源抗SARS-CoV-2单克隆抗体注射液联合疗法的进展，在降低病毒载量、减轻症状及降低和冠状病毒相关的住院及急诊治疗方面均显示出良好疗效。

君实生物公布其重组全人源抗SARS-CoV-2单克隆抗体注射液联合疗法的进展，在降低病毒载量、减轻症状及降低和冠状病毒相关的住院及急诊治疗方面均显示出良好疗效。

LY-CoV555为礼来与AbCellera公司合作开发的一款有效中和IgG1的单克隆抗体，直接抑制SARS-CoV-2病毒的棘突蛋白。该抗体的设计原理为阻断病毒附着、进入人体细胞，从而中和该病毒、具有潜在的预防和治疗COVID-19的效果。

JS016 (LY-CoV016)是一款重组全人源单克隆中和抗体，以高亲和力特异性结合SARS-CoV-2表面刺突蛋白受体结构域，并能有效阻断病毒与宿主细胞表面受体ACE2的结合。JS016(LY-CoV016)在预防及治疗SARS-CoV-2感染方面均具有良好疗效。

君实生物与中国科学院微生物研究所共同开发JS016后，美国礼来制药公司从君实生物引进JS016，君实生物将主导大中华地区(包括中国大陆、香港特别行政区、澳门特别行政区及台湾地区)的开发活动，而礼来制药将主导全球其他地区的开发活动。

君实生物已在中国健康受试者中完成了评估安全性、耐受性、药代动力学特征及免疫原性的I期研究，并正在开展国际多中心的Ib/II期临床试验。

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2021-09-10 hukaixun

#SARS-CoV#

37 0
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2021-01-27 aids221

#克隆#

36 0
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2020-10-11 691273246

点赞

93 0
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2020-10-10 小刀医生

#SARS#

0 0
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2020-10-10 智智灵药

#注射液#

49 0
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2020-10-09 ms3000000546723755

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君实生物重组全人源抗SARS-CoV-2单克隆抗体注射液进展良好

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