JAMA Surg:辅助化疗与胃癌患者生存时间的关系

2017-07-30 xuyihan MedSci原创

目前的癌症评分系统不能很好的预测胃癌患者在接受了辅助化疗后的预后情况。近期来自中国的研究人员构建了一种基于特异性肿瘤和患者特征的生存预测模型,其能够对II期或III期胃癌患者行辅助化疗的生存时间进行个体化预测。

目前的癌症评分系统不能很好的预测胃癌患者在接受了辅助化疗后的预后情况。近期来自中国的研究人员构建了一种基于特异性肿瘤和患者特征的生存预测模型,其能够对II期或III期胃癌患者行辅助化疗的生存时间进行个体化预测。

研究人员收集了2004年1月至2012年12月间在南方医院因II期或III期胃癌行胃切除术的746名患者的临床资料进行了多中心回顾性分析。病人情况与肿瘤特点作为研究协变量纳入研究分析,该预测模型在内部使用排除歧视与标准进行调校。并收集来自中国广州第一医院和四川华西医院的973例II期或III期胃癌患者资料进行外部模型预测验证。

结果显示:在纳入的1719例患者中,1183例(68.8%)为男性,536例(31.2%)为女性,中位数(四分位数范围)年龄为57岁(49-66岁)。 年龄,肿瘤位置,分化程度,癌胚抗原水平,癌抗原19-9水平,入侵深度,淋巴结转移程度和是否采用辅助化疗均与总生存期和生存率有显着相关性(P <0.05)。 生存预测模型表现出良好的准确性。

此项研究表明采用生存预测模型可用于判断II期或III期胃癌患者是否进行辅助化疗,能对患者的生存获益进行个性化预测。

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