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Eur Radiol：新技术！多光谱光声层析成像中正常乳腺组织和恶性病变的影像特点

2017-08-16 shaosai MedSci原创

多光谱光声层析成像乳腺癌超声
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“多光谱光声层析成像（MSOT）是一种新的成像技术，可以无创定量血红蛋白相关的组织灌注和氧合作用，”德国纽伦堡大学Maximilian J. Waldner博士和同事们写道。“这种方法使用近红外波长短脉冲激光的激发在靶向组织中诱导光声效应，这会导致检测到热膨胀引起的声波。”利用光声效应具有高分辨率(~250 μm)、组织穿透力强(>1 cm)的特点。超声包含病变解剖学信息，MSOT能够基于组织内在

“多光谱光声层析成像（MSOT）是一种新的成像技术，可以无创定量血红蛋白相关的组织灌注和氧合作用，”德国纽伦堡大学Maximilian J. Waldner博士和同事们写道。“这种方法使用近红外波长短脉冲激光的激发在靶向组织中诱导光声效应，这会导致检测到热膨胀引起的声波。”利用光声效应具有高分辨率(~250 μm)、组织穿透力强(>1 cm)的特点。超声包含病变解剖学信息，MSOT能够基于组织内在的生色团的特点提供功能学信息。本研究旨在结合超声/MSOT成像评价乳腺癌患者与健康志愿者的差异性，并将结果发表在Eur Radiol上。

使用临床掌上型MSOT系统对健康志愿者(n=6)和典型浸润性乳腺癌(n=5)和原位管癌(DCIS，n=2)患者。在0.5、1.0和1.5CM深度，选择波长700~ 850在评价代表血红蛋白和氧饱和度的MSOT值。

在健康志愿者乳腺表浅组织在各种波长间可获得可重复性稳定的MSOT信号。相比，在浸润性乳腺癌中，血红蛋白信号增高，表明肿瘤具有高灌注的血供和肿瘤环境。对DCIS，与健康志愿者相比，MSOT值仅有轻度的差异。

本研究表明，MSOT成像初步研究表明其能够对组织成分和生理学特征提供稳定可重复的数据，从而具有鉴别实性恶性病变和正常组织的潜能。

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  1. [GetPortalCommentsPageByObjectIdResponse(id=1903768, encodeId=f3301903e6862, content=<a href='/topic/show?id=be285836438' target=_blank style='color:#2F92EE;'>#新技术#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=58364, encryptionId=be285836438, topicName=新技术)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d39f177, createdName=lixiao3326, createdTime=Mon Apr 16 10:48:00 CST 2018, time=2018-04-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=234375, encodeId=6b6c2343e561, content=好好学习，谢谢分享！, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLANEL7Sww3HicKsN9aribicAmGGWXOIMEiaZ1iadgZg9RibjqSwIKUS8gSPib2NwTVg2zVvVJhdP3BkuDIl/0, createdBy=944d1605392, createdName=shaosai, createdTime=Thu Aug 17 09:37:47 CST 2017, time=2017-08-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=234256, encodeId=c9612342567d, content=学习了，谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLGSUSR8zwnWWLT4FMl5XH8S58HuZslVkLsAPbXDXaliagK7TOxQfmngKibG1yrDonepCLDkcxGk8hS/0, createdBy=b8282062892, createdName=changjiu, createdTime=Thu Aug 17 06:27:51 CST 2017, time=2017-08-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=234230, encodeId=0ee323423056, content=MSOT成像初步研究表明其能够对组织成分和生理学特征提供稳定可重复的数据，从而具有鉴别实性恶性病变和正常组织的潜能。, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7cJ6ejWUr2nIia8qOvAKNdLHr32Df6G8iaoaOx6pHaoiacwp26DaslxZHCGbibZhhCGven4rvmWP60GahtzgFjgCjR/0, createdBy=6b111703011, createdName=有备才能无患, createdTime=Wed Aug 16 23:24:21 CST 2017, time=2017-08-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=234207, encodeId=0c7923420e74, content=学习了，涨知识, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20220115/46bcf39c32de4aa6b45c5f9d66c8ee77/6cb4a20c55bb4b7691122f47747bfca2.jpg, createdBy=9dad1662329, createdName=1ddf0692m34(暂无匿称), createdTime=Wed Aug 16 22:30:57 CST 2017, time=2017-08-16, status=1, ipAttribution=)]
    2018-04-16 lixiao3326

    #新技术#

    0

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    2017-08-17 shaosai

    好好学习，谢谢分享！

    0

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    2017-08-17 changjiu

    学习了，谢谢

    0

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    2017-08-16 有备才能无患

    MSOT成像初步研究表明其能够对组织成分和生理学特征提供稳定可重复的数据，从而具有鉴别实性恶性病变和正常组织的潜能。

    0

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    2017-08-16 1ddf0692m34(暂无匿称)

    学习了，涨知识

    0