Diabetes Care:母亲孕期患妊娠期糖尿病,会增加后代2型糖尿病风险

2016-10-12 MedSci MedSci原创

本研究旨在探讨宫内妊娠期糖尿病(GDM)暴露和第一民族(FN)状态,对后代生命前30年的2型糖尿病风险的影响。 第一民族(First Nations,FN),是一个加拿大的种族名称,与印地安人(Indian)同义,指的是在现今加拿大境内的北美洲原住民及其子孙,但是不包括因努伊特人和梅提斯人。 在这项历史前瞻性队列研究中,我们通过临床数据库,调查了GDM和FN状态与后代2型糖尿病风险之间

本研究旨在探讨宫内妊娠期糖尿病(GDM)暴露和第一民族(FN)状态,对后代生命前30年的2型糖尿病风险的影响。 第一民族(First Nations,FN),是一个加拿大的种族名称,与印地安人(Indian)同义,指的是在现今加拿大境内的北美洲原住民及其子孙,但是不包括因努伊特人和梅提斯人。 在这项历史前瞻性队列研究中,我们通过临床数据库,调查了GDM和FN状态与后代2型糖尿病风险之间的联系,以及相互作用。 研究共纳入了321008名后代,中位数随访15.1年。母亲孕期GDM和FN状态均与后代生命前30年的2型糖尿病风险独立相关(HR 3.03 [95% CI 2.44–3.76; P < 0.0001] vs. 4.86 [95% CI 4.08–5.79; P < 0.0001)。母亲孕期GDM和FN状态对后代2型糖尿病风险影响之间无交互作用。FN状态与母亲孕期GDM相比,对后代2型糖尿病风险的影响更强烈。 结果表明,妊娠期糖尿病是后代患2型糖尿病的风险因素,但也是可以预防的因素;通过预防母亲孕期GDM,可显著降低后代2型糖尿病患病率。 原始出处: Eliza

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    2016-10-14 忠诚向上

    预防为主

    0

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    2016-10-12 忠诚向上

    内容丰富

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    2016-10-12 15616ecc81m

    孩子真是母亲的延续

    0

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