Nature:无需切片染色,改良的三维显微术可对肿瘤迅速活检

2017-06-27 佚名 Nature自然科研

《自然-生物医学工程》本周在线发表的一项研究论文Light-sheet microscopy for slide-free nondestructivepathology of large clinical specimens利用改进的显微镜,实现了对完整的大型临床组织的快速成像。运用这种新方法,临床病理学家能在数分钟内获得整个样本的三维可视化图像,从而提高诊断准确性;举例来说,这项技术可用于手术

《自然-生物医学工程》本周在线发表的一项研究论文Light-sheet microscopy for slide-free nondestructivepathology of large clinical specimens利用改进的显微镜,实现了对完整的大型临床组织的快速成像。运用这种新方法,临床病理学家能在数分钟内获得整个样本的三维可视化图像,从而提高诊断准确性;举例来说,这项技术可用于手术后的肿瘤组织。

传统上,在通过手术取出组织样本后,病理学家首先会通过化学固定来保留其结构,然后将组织切成薄片,放置在载玻片上,随后用染料染色。 由于这一过程十分费时费力,一个样本中实际上只有几个组织切片得到了显微镜分析,为诊断提供信息。这一限制可能会显著影响临床医生正确做出决定的能力,导致病理分型错误。

美国西雅图华盛顿大学的Jonathan Liu及同事优化了扫描样本切片的荧光显微镜,表明手术样本可在数分钟内成像,且无需样本处理。 作者表明,显微镜可快速识别肿瘤切缘,通过避免标准组织病理学方法中产生的伪影,提供更准确的临床组织样本评估,从而改善患者诊断。


大块人体前列腺组织的显微镜图像。

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    2017-09-06 liye789132251
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    2017-06-28 smlt2008
  3. [GetPortalCommentsPageByObjectIdResponse(id=1882219, encodeId=88f9188221951, content=<a href='/topic/show?id=3b2112532d8' target=_blank style='color:#2F92EE;'>#Nat#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12532, encryptionId=3b2112532d8, topicName=Nat)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2e6f107, createdName=liye789132251, createdTime=Wed Sep 06 21:23:00 CST 2017, time=2017-09-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1278015, encodeId=4b5112e8015f4, content=<a href='/topic/show?id=d34e6523544' target=_blank style='color:#2F92EE;'>#活检#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=65235, encryptionId=d34e6523544, topicName=活检)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c39f145, createdName=smlt2008, createdTime=Wed Jun 28 22:23:00 CST 2017, time=2017-06-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=216021, encodeId=641821602111, content=厉害啊!!学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=aadd1680584, createdName=蔬菜, createdTime=Tue Jun 27 16:48:00 CST 2017, time=2017-06-27, status=1, ipAttribution=)]
    2017-06-27 蔬菜

    厉害啊!!学习了

    0