营养科

订阅

MedSci主页 / 所有栏目 / 营养科

J Cell Mol Med：神经营养因子-3作用于大鼠异位骨化的内皮-间质转化

2019-01-25 MedSci MedSci原创

关注

尽管很多研究集中于探究异位成骨（HO），但其分子机制尚不清楚。可被神经内分泌细胞因子部分调节的内皮-间质转化（EndMT）被认为在HO中起主要作用。具有神经内分泌特征的神经营养因子-3（NT-3）被认为促进骨骼重塑。在这里，我们认为NT-3可以通过调节EndMT促进HO的形成。本研究中，我们使用HO的体内模型和EndMT诱导的体外模型来阐明NT-3对HO中EndMT的作用和潜在机制。结果显示，En

尽管很多研究集中于探究异位成骨（HO），但其分子机制尚不清楚。可被神经内分泌细胞因子部分调节的内皮-间质转化（EndMT）被认为在HO中起主要作用。具有神经内分泌特征的神经营养因子-3（NT-3）被认为促进骨骼重塑。在这里，我们认为NT-3可以通过调节EndMT促进HO的形成。本研究中，我们使用HO的体内模型和EndMT诱导的体外模型来阐明NT-3对HO中EndMT的作用和潜在机制。

结果显示，EndMT和NT-3引起的异位骨和软骨在体内促进HO形成。体外结果显示NT-3上调间充质标记物（FSP-1，α-SMA和N-钙粘蛋白）和间充质干细胞（MSC）标记物（STRO-1，CD44和CD90）和下调内皮细胞标记物（Tie-1，VE-cadherin和CD31）。此外，NT-3通过激活EndMT增强了软骨形成标记（Sox9）和成骨标记（OCN和Runx2）的表达。然而，EndMT特异性抑制剂和原肌球蛋白相关激酶C（TrkC）特异性抑制剂均在体内和体外挽救了NT-3诱导的HO形成和EndMT诱导。

总之，该研究结果表明，NT-3通过体内和体外调节EndMT促进HO的形成，这为HO的预防和治疗提供了新的潜在靶点。

原始出处：

Zhang J, Wang L, et al., Neurotrophin-3 acts on the endothelial-mesenchymal transition of heterotopic ossification in rats. J Cell Mol Med. 2019 Jan 22. doi: 10.1111/jcmm.14150.

版权声明：
本网站所有内容来源注明为“梅斯医学”或“MedSci原创”的文字、图片和音视频资料，版权均属于梅斯医学所有。非经授权，任何媒体、网站或个人不得转载，授权转载时须注明来源为“梅斯医学”。其它来源的文章系转载文章，或“梅斯号”自媒体发布的文章，仅系出于传递更多信息之目的，本站仅负责审核内容合规，其内容不代表本站立场，本站不负责内容的准确性和版权。如果存在侵权、或不希望被转载的媒体或个人可与我们联系，我们将立即进行删除处理。
在此留言
评论区 (8)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=1801932, encodeId=f31a1801932b4, content=<a href='/topic/show?id=f82de453923' target=_blank style='color:#2F92EE;'>#神经营养#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=74539, encryptionId=f82de453923, topicName=神经营养)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d64f419, createdName=qindq, createdTime=Sat Apr 13 00:24:00 CST 2019, time=2019-04-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1871098, encodeId=081918e1098c5, content=<a href='/topic/show?id=fd764459a8' target=_blank style='color:#2F92EE;'>#Cell#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4459, encryptionId=fd764459a8, topicName=Cell)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=524d95, createdName=zhaozhouchifen, createdTime=Fri Aug 30 17:24:00 CST 2019, time=2019-08-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1961375, encodeId=5f5619613e520, content=<a href='/topic/show?id=dbe6445416' target=_blank style='color:#2F92EE;'>#CEL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=18, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4454, encryptionId=dbe6445416, topicName=CEL)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3ff68, createdName=维他命, createdTime=Tue Jan 07 13:24:00 CST 2020, time=2020-01-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2041327, encodeId=1546204132eb8, content=<a href='/topic/show?id=5958e454081' target=_blank style='color:#2F92EE;'>#神经营养因子#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=74540, encryptionId=5958e454081, topicName=神经营养因子)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=21015, createdName=heli0118, createdTime=Thu Dec 26 20:24:00 CST 2019, time=2019-12-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1609504, encodeId=77ef160950431, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Sun Jan 27 11:24:00 CST 2019, time=2019-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=359227, encodeId=ffc535922edd, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2019/01/25/96062b4292ae2e61be98f77299c09516.jpg, createdBy=7c632537795, createdName=125159d9m09暂无昵称, createdTime=Fri Jan 25 21:34:59 CST 2019, time=2019-01-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=359226, encodeId=085635922699, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2019/01/25/96062b4292ae2e61be98f77299c09516.jpg, createdBy=7c632537795, createdName=125159d9m09暂无昵称, createdTime=Fri Jan 25 21:33:50 CST 2019, time=2019-01-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=359225, encodeId=c549359225ca, content=棒, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2019/01/25/96062b4292ae2e61be98f77299c09516.jpg, createdBy=7c632537795, createdName=125159d9m09暂无昵称, createdTime=Fri Jan 25 21:33:04 CST 2019, time=2019-01-25, status=1, ipAttribution=)]
    2019-04-13 qindq

    #神经营养#

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=1801932, encodeId=f31a1801932b4, content=<a href='/topic/show?id=f82de453923' target=_blank style='color:#2F92EE;'>#神经营养#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=74539, encryptionId=f82de453923, topicName=神经营养)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d64f419, createdName=qindq, createdTime=Sat Apr 13 00:24:00 CST 2019, time=2019-04-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1871098, encodeId=081918e1098c5, content=<a href='/topic/show?id=fd764459a8' target=_blank style='color:#2F92EE;'>#Cell#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4459, encryptionId=fd764459a8, topicName=Cell)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=524d95, createdName=zhaozhouchifen, createdTime=Fri Aug 30 17:24:00 CST 2019, time=2019-08-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1961375, encodeId=5f5619613e520, content=<a href='/topic/show?id=dbe6445416' target=_blank style='color:#2F92EE;'>#CEL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=18, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4454, encryptionId=dbe6445416, topicName=CEL)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3ff68, createdName=维他命, createdTime=Tue Jan 07 13:24:00 CST 2020, time=2020-01-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2041327, encodeId=1546204132eb8, content=<a href='/topic/show?id=5958e454081' target=_blank style='color:#2F92EE;'>#神经营养因子#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=74540, encryptionId=5958e454081, topicName=神经营养因子)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=21015, createdName=heli0118, createdTime=Thu Dec 26 20:24:00 CST 2019, time=2019-12-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1609504, encodeId=77ef160950431, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Sun Jan 27 11:24:00 CST 2019, time=2019-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=359227, encodeId=ffc535922edd, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2019/01/25/96062b4292ae2e61be98f77299c09516.jpg, createdBy=7c632537795, createdName=125159d9m09暂无昵称, createdTime=Fri Jan 25 21:34:59 CST 2019, time=2019-01-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=359226, encodeId=085635922699, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2019/01/25/96062b4292ae2e61be98f77299c09516.jpg, createdBy=7c632537795, createdName=125159d9m09暂无昵称, createdTime=Fri Jan 25 21:33:50 CST 2019, time=2019-01-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=359225, encodeId=c549359225ca, content=棒, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2019/01/25/96062b4292ae2e61be98f77299c09516.jpg, createdBy=7c632537795, createdName=125159d9m09暂无昵称, createdTime=Fri Jan 25 21:33:04 CST 2019, time=2019-01-25, status=1, ipAttribution=)]
    2019-08-30 zhaozhouchifen

    #Cell#

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=1801932, encodeId=f31a1801932b4, content=<a href='/topic/show?id=f82de453923' target=_blank style='color:#2F92EE;'>#神经营养#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=74539, encryptionId=f82de453923, topicName=神经营养)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d64f419, createdName=qindq, createdTime=Sat Apr 13 00:24:00 CST 2019, time=2019-04-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1871098, encodeId=081918e1098c5, content=<a href='/topic/show?id=fd764459a8' target=_blank style='color:#2F92EE;'>#Cell#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4459, encryptionId=fd764459a8, topicName=Cell)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=524d95, createdName=zhaozhouchifen, createdTime=Fri Aug 30 17:24:00 CST 2019, time=2019-08-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1961375, encodeId=5f5619613e520, content=<a href='/topic/show?id=dbe6445416' target=_blank style='color:#2F92EE;'>#CEL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=18, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4454, encryptionId=dbe6445416, topicName=CEL)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3ff68, createdName=维他命, createdTime=Tue Jan 07 13:24:00 CST 2020, time=2020-01-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2041327, encodeId=1546204132eb8, content=<a href='/topic/show?id=5958e454081' target=_blank style='color:#2F92EE;'>#神经营养因子#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=74540, encryptionId=5958e454081, topicName=神经营养因子)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=21015, createdName=heli0118, createdTime=Thu Dec 26 20:24:00 CST 2019, time=2019-12-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1609504, encodeId=77ef160950431, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Sun Jan 27 11:24:00 CST 2019, time=2019-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=359227, encodeId=ffc535922edd, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2019/01/25/96062b4292ae2e61be98f77299c09516.jpg, createdBy=7c632537795, createdName=125159d9m09暂无昵称, createdTime=Fri Jan 25 21:34:59 CST 2019, time=2019-01-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=359226, encodeId=085635922699, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2019/01/25/96062b4292ae2e61be98f77299c09516.jpg, createdBy=7c632537795, createdName=125159d9m09暂无昵称, createdTime=Fri Jan 25 21:33:50 CST 2019, time=2019-01-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=359225, encodeId=c549359225ca, content=棒, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2019/01/25/96062b4292ae2e61be98f77299c09516.jpg, createdBy=7c632537795, createdName=125159d9m09暂无昵称, createdTime=Fri Jan 25 21:33:04 CST 2019, time=2019-01-25, status=1, ipAttribution=)]
    2020-01-07 维他命

    #CEL#

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=1801932, encodeId=f31a1801932b4, content=<a href='/topic/show?id=f82de453923' target=_blank style='color:#2F92EE;'>#神经营养#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=74539, encryptionId=f82de453923, topicName=神经营养)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d64f419, createdName=qindq, createdTime=Sat Apr 13 00:24:00 CST 2019, time=2019-04-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1871098, encodeId=081918e1098c5, content=<a href='/topic/show?id=fd764459a8' target=_blank style='color:#2F92EE;'>#Cell#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4459, encryptionId=fd764459a8, topicName=Cell)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=524d95, createdName=zhaozhouchifen, createdTime=Fri Aug 30 17:24:00 CST 2019, time=2019-08-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1961375, encodeId=5f5619613e520, content=<a href='/topic/show?id=dbe6445416' target=_blank style='color:#2F92EE;'>#CEL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=18, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4454, encryptionId=dbe6445416, topicName=CEL)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3ff68, createdName=维他命, createdTime=Tue Jan 07 13:24:00 CST 2020, time=2020-01-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2041327, encodeId=1546204132eb8, content=<a href='/topic/show?id=5958e454081' target=_blank style='color:#2F92EE;'>#神经营养因子#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=74540, encryptionId=5958e454081, topicName=神经营养因子)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=21015, createdName=heli0118, createdTime=Thu Dec 26 20:24:00 CST 2019, time=2019-12-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1609504, encodeId=77ef160950431, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Sun Jan 27 11:24:00 CST 2019, time=2019-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=359227, encodeId=ffc535922edd, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2019/01/25/96062b4292ae2e61be98f77299c09516.jpg, createdBy=7c632537795, createdName=125159d9m09暂无昵称, createdTime=Fri Jan 25 21:34:59 CST 2019, time=2019-01-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=359226, encodeId=085635922699, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2019/01/25/96062b4292ae2e61be98f77299c09516.jpg, createdBy=7c632537795, createdName=125159d9m09暂无昵称, createdTime=Fri Jan 25 21:33:50 CST 2019, time=2019-01-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=359225, encodeId=c549359225ca, content=棒, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2019/01/25/96062b4292ae2e61be98f77299c09516.jpg, createdBy=7c632537795, createdName=125159d9m09暂无昵称, createdTime=Fri Jan 25 21:33:04 CST 2019, time=2019-01-25, status=1, ipAttribution=)]
    2019-12-26 heli0118

    #神经营养因子#

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1801932, encodeId=f31a1801932b4, content=<a href='/topic/show?id=f82de453923' target=_blank style='color:#2F92EE;'>#神经营养#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=74539, encryptionId=f82de453923, topicName=神经营养)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d64f419, createdName=qindq, createdTime=Sat Apr 13 00:24:00 CST 2019, time=2019-04-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1871098, encodeId=081918e1098c5, content=<a href='/topic/show?id=fd764459a8' target=_blank style='color:#2F92EE;'>#Cell#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4459, encryptionId=fd764459a8, topicName=Cell)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=524d95, createdName=zhaozhouchifen, createdTime=Fri Aug 30 17:24:00 CST 2019, time=2019-08-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1961375, encodeId=5f5619613e520, content=<a href='/topic/show?id=dbe6445416' target=_blank style='color:#2F92EE;'>#CEL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=18, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4454, encryptionId=dbe6445416, topicName=CEL)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3ff68, createdName=维他命, createdTime=Tue Jan 07 13:24:00 CST 2020, time=2020-01-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2041327, encodeId=1546204132eb8, content=<a href='/topic/show?id=5958e454081' target=_blank style='color:#2F92EE;'>#神经营养因子#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=74540, encryptionId=5958e454081, topicName=神经营养因子)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=21015, createdName=heli0118, createdTime=Thu Dec 26 20:24:00 CST 2019, time=2019-12-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1609504, encodeId=77ef160950431, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Sun Jan 27 11:24:00 CST 2019, time=2019-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=359227, encodeId=ffc535922edd, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2019/01/25/96062b4292ae2e61be98f77299c09516.jpg, createdBy=7c632537795, createdName=125159d9m09暂无昵称, createdTime=Fri Jan 25 21:34:59 CST 2019, time=2019-01-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=359226, encodeId=085635922699, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2019/01/25/96062b4292ae2e61be98f77299c09516.jpg, createdBy=7c632537795, createdName=125159d9m09暂无昵称, createdTime=Fri Jan 25 21:33:50 CST 2019, time=2019-01-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=359225, encodeId=c549359225ca, content=棒, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2019/01/25/96062b4292ae2e61be98f77299c09516.jpg, createdBy=7c632537795, createdName=125159d9m09暂无昵称, createdTime=Fri Jan 25 21:33:04 CST 2019, time=2019-01-25, status=1, ipAttribution=)]
    2019-01-27 ms3994565386320060

    #Med#

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1801932, encodeId=f31a1801932b4, content=<a href='/topic/show?id=f82de453923' target=_blank style='color:#2F92EE;'>#神经营养#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=74539, encryptionId=f82de453923, topicName=神经营养)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d64f419, createdName=qindq, createdTime=Sat Apr 13 00:24:00 CST 2019, time=2019-04-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1871098, encodeId=081918e1098c5, content=<a href='/topic/show?id=fd764459a8' target=_blank style='color:#2F92EE;'>#Cell#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4459, encryptionId=fd764459a8, topicName=Cell)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=524d95, createdName=zhaozhouchifen, createdTime=Fri Aug 30 17:24:00 CST 2019, time=2019-08-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1961375, encodeId=5f5619613e520, content=<a href='/topic/show?id=dbe6445416' target=_blank style='color:#2F92EE;'>#CEL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=18, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4454, encryptionId=dbe6445416, topicName=CEL)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3ff68, createdName=维他命, createdTime=Tue Jan 07 13:24:00 CST 2020, time=2020-01-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2041327, encodeId=1546204132eb8, content=<a href='/topic/show?id=5958e454081' target=_blank style='color:#2F92EE;'>#神经营养因子#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=74540, encryptionId=5958e454081, topicName=神经营养因子)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=21015, createdName=heli0118, createdTime=Thu Dec 26 20:24:00 CST 2019, time=2019-12-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1609504, encodeId=77ef160950431, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Sun Jan 27 11:24:00 CST 2019, time=2019-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=359227, encodeId=ffc535922edd, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2019/01/25/96062b4292ae2e61be98f77299c09516.jpg, createdBy=7c632537795, createdName=125159d9m09暂无昵称, createdTime=Fri Jan 25 21:34:59 CST 2019, time=2019-01-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=359226, encodeId=085635922699, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2019/01/25/96062b4292ae2e61be98f77299c09516.jpg, createdBy=7c632537795, createdName=125159d9m09暂无昵称, createdTime=Fri Jan 25 21:33:50 CST 2019, time=2019-01-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=359225, encodeId=c549359225ca, content=棒, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2019/01/25/96062b4292ae2e61be98f77299c09516.jpg, createdBy=7c632537795, createdName=125159d9m09暂无昵称, createdTime=Fri Jan 25 21:33:04 CST 2019, time=2019-01-25, status=1, ipAttribution=)]
    2019-01-25 125159d9m09暂无昵称

    学习

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=1801932, encodeId=f31a1801932b4, content=<a href='/topic/show?id=f82de453923' target=_blank style='color:#2F92EE;'>#神经营养#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=74539, encryptionId=f82de453923, topicName=神经营养)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d64f419, createdName=qindq, createdTime=Sat Apr 13 00:24:00 CST 2019, time=2019-04-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1871098, encodeId=081918e1098c5, content=<a href='/topic/show?id=fd764459a8' target=_blank style='color:#2F92EE;'>#Cell#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4459, encryptionId=fd764459a8, topicName=Cell)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=524d95, createdName=zhaozhouchifen, createdTime=Fri Aug 30 17:24:00 CST 2019, time=2019-08-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1961375, encodeId=5f5619613e520, content=<a href='/topic/show?id=dbe6445416' target=_blank style='color:#2F92EE;'>#CEL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=18, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4454, encryptionId=dbe6445416, topicName=CEL)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3ff68, createdName=维他命, createdTime=Tue Jan 07 13:24:00 CST 2020, time=2020-01-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2041327, encodeId=1546204132eb8, content=<a href='/topic/show?id=5958e454081' target=_blank style='color:#2F92EE;'>#神经营养因子#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=74540, encryptionId=5958e454081, topicName=神经营养因子)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=21015, createdName=heli0118, createdTime=Thu Dec 26 20:24:00 CST 2019, time=2019-12-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1609504, encodeId=77ef160950431, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Sun Jan 27 11:24:00 CST 2019, time=2019-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=359227, encodeId=ffc535922edd, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2019/01/25/96062b4292ae2e61be98f77299c09516.jpg, createdBy=7c632537795, createdName=125159d9m09暂无昵称, createdTime=Fri Jan 25 21:34:59 CST 2019, time=2019-01-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=359226, encodeId=085635922699, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2019/01/25/96062b4292ae2e61be98f77299c09516.jpg, createdBy=7c632537795, createdName=125159d9m09暂无昵称, createdTime=Fri Jan 25 21:33:50 CST 2019, time=2019-01-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=359225, encodeId=c549359225ca, content=棒, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2019/01/25/96062b4292ae2e61be98f77299c09516.jpg, createdBy=7c632537795, createdName=125159d9m09暂无昵称, createdTime=Fri Jan 25 21:33:04 CST 2019, time=2019-01-25, status=1, ipAttribution=)]
    2019-01-25 125159d9m09暂无昵称

    学习

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=1801932, encodeId=f31a1801932b4, content=<a href='/topic/show?id=f82de453923' target=_blank style='color:#2F92EE;'>#神经营养#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=74539, encryptionId=f82de453923, topicName=神经营养)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d64f419, createdName=qindq, createdTime=Sat Apr 13 00:24:00 CST 2019, time=2019-04-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1871098, encodeId=081918e1098c5, content=<a href='/topic/show?id=fd764459a8' target=_blank style='color:#2F92EE;'>#Cell#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4459, encryptionId=fd764459a8, topicName=Cell)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=524d95, createdName=zhaozhouchifen, createdTime=Fri Aug 30 17:24:00 CST 2019, time=2019-08-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1961375, encodeId=5f5619613e520, content=<a href='/topic/show?id=dbe6445416' target=_blank style='color:#2F92EE;'>#CEL#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=18, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4454, encryptionId=dbe6445416, topicName=CEL)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3ff68, createdName=维他命, createdTime=Tue Jan 07 13:24:00 CST 2020, time=2020-01-07, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2041327, encodeId=1546204132eb8, content=<a href='/topic/show?id=5958e454081' target=_blank style='color:#2F92EE;'>#神经营养因子#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=74540, encryptionId=5958e454081, topicName=神经营养因子)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=21015, createdName=heli0118, createdTime=Thu Dec 26 20:24:00 CST 2019, time=2019-12-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1609504, encodeId=77ef160950431, content=<a href='/topic/show?id=eb6b1145939' target=_blank style='color:#2F92EE;'>#Med#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=11459, encryptionId=eb6b1145939, topicName=Med)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=552a19396740, createdName=ms3994565386320060, createdTime=Sun Jan 27 11:24:00 CST 2019, time=2019-01-27, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=359227, encodeId=ffc535922edd, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2019/01/25/96062b4292ae2e61be98f77299c09516.jpg, createdBy=7c632537795, createdName=125159d9m09暂无昵称, createdTime=Fri Jan 25 21:34:59 CST 2019, time=2019-01-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=359226, encodeId=085635922699, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2019/01/25/96062b4292ae2e61be98f77299c09516.jpg, createdBy=7c632537795, createdName=125159d9m09暂无昵称, createdTime=Fri Jan 25 21:33:50 CST 2019, time=2019-01-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=359225, encodeId=c549359225ca, content=棒, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2019/01/25/96062b4292ae2e61be98f77299c09516.jpg, createdBy=7c632537795, createdName=125159d9m09暂无昵称, createdTime=Fri Jan 25 21:33:04 CST 2019, time=2019-01-25, status=1, ipAttribution=)]
    2019-01-25 125159d9m09暂无昵称

    棒

    0