Stroke:血液透析患者血清磷水平与脑卒中风险的关系

2016-09-26 MedSci MedSci原创

研究结果表明较高的血清磷酸盐水平与脑出血的风险增加有关,而低水平与血液透析患者的脑梗塞风险增加有关。因此,将血液透析患者的血清磷酸盐水平控制在一个适当的范围很重要。

透析患者血清磷酸盐水平对卒中风险有何作用仍不清楚,最近,卒中领域权威杂志《Stroke》发表了日本学者Yamada的研究成果,该项目旨在阐明血清磷酸盐水平与血液透析患者的脑出血或梗死风险之间的关联。

研究共纳入3437例接受血液透析的患者,中位随访3.9年,主要观察指标是脑出血或梗死的发生情况,根据患者血清磷酸盐基础水平分为4组(Q1–Q4)。采用Cox比例风险模型估计卒中的风险。


在随访期间,共有75例患者发生脑出血和139例患者发生脑梗死,最高血清磷酸盐组(Q4)的脑出血的风险显著高于作为参考值的最低血清磷酸盐组(Q1)(多变量调整后的危险比[95%可信区间]:Q1,1.00;Q2,1.76 [0.79-4.18];Q3,1.99 [0.92-4.67];和Q4,2.74 [1.27–6.47];P=0.077;血清磷酸盐水平每增加1mmol/L的风险比为2.07 [1.10–3.81];P=0.025)。

相反,在Q1组脑梗塞的风险显著高于作为参考值的Q3(P=0.045)(Q1,1.65 [1.01–2.73];Q2,1.35 [0.82–2.25]; Q3,1.00;Q4;1.30 [0.77–2.20])。

研究结果表明较高的血清磷酸盐水平与脑出血的风险增加有关,而低水平与血液透析患者的脑梗塞风险增加有关。因此,将血液透析患者的血清磷酸盐水平控制在一个适当的范围很重要。

原始出处:

Shunsuke Yamada,et al. Association Between Serum Phosphate Levels and Stroke Risk in Patients Undergoing Hemodialysis. Stroke. 2016. 

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    2016-10-11 xyfg98

    学习了,多谢分享!

    0

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    2016-10-11 xyfg98

    学习了,多谢分享!

    0

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    2016-10-11 xyfg98

    学习了,多谢分享!

    0

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    2016-09-28 habb
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