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他汀类药物治疗可降低AS+PsA患者的心血管风险和总死亡率

2016-11-14 MedSci MedSci原创

他汀类心血管死亡强直性脊柱炎银屑病关节炎
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根据美国风湿病学会年会上提交的调查结果显示，使用他汀类药物可以让强直性脊柱炎+银屑病关节炎患者的死亡率下降32%。 Amar Oza博士和同事们对2904例强直性脊柱炎(AS)+银屑病关节炎(PsA)患者进行了研究，研究他汀类药物对这类患者的生存益处。 平均随访时间为5.3年，他汀类使用者中死亡人数为271例；对照组5.15年的随访期间内，死亡人数为376例。他汀类药物使用组的死亡率为

根据美国风湿病学会年会上提交的调查结果显示，使用他汀类药物可以让强直性脊柱炎+银屑病关节炎患者的死亡率下降32%。

Amar Oza博士和同事们对2904例强直性脊柱炎(AS)+银屑病关节炎(PsA)患者进行了研究，研究他汀类药物对这类患者的生存益处。

平均随访时间为5.3年，他汀类使用者中死亡人数为271例；对照组5.15年的随访期间内，死亡人数为376例。他汀类药物使用组的死亡率为17.6/1000人年，非他汀类药物使用组的死亡率为25.1/1000人年。

使用他汀类药物治疗与全因死亡率降低32%有关（HR= 0.68）。

研究人员还对非匹配队列进行了比较，以调查倾向得分匹配是否有效。涉及3389名他汀类药物使用者和3389名非他汀类药物使用者，使用他汀类药物可让死亡率增加了44%(HR = 1.44)。

Oza说：“对于病情加重的患者，使用他汀类药物与较高的死亡率有关。”

治疗组和对照组的基线参数相似。研究人员对包括疾病持续时间、社会经济地位、体重指数、生活方式因素和药物使用等50个变量进行多变量分析。

他汀类药物治疗可以降低AS+PsA患者的心血管风险和总死亡率。

原始出处：

Oza A, et al. Abstract #910. Presented at: The American College of Rheumatology Annual Meeting; Nov. 11-16, 2016. Washington.

Statin use linked with reduced mortality among patients with AS and PsA.Healio.November 13, 2016

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    2017-08-17 ms5353107019656438

    #血管风险#

    0

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    2017-10-08 ms6390871039024434

    #他汀类药#

    0

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    2016-11-16 大旺旺

    学习了啊

    0

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    2016-11-16 zhaozhouchifen

    #PSA#

    0

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    2016-11-14 wxl882001

    好资料，值得学习

    0

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