J Clin Periodontol: 光动力疗法与阿仑膦酸钠对结扎性牙周炎大鼠牙槽骨吸收的协同作用

2018-05-21 MedSci MedSci原创

光动力治疗(PDT)和抗吸收药物,如阿仑膦酸盐(ALN),已被证明可减少牙槽骨吸收。本研究的目的是评估PDT和ALN联合应用对大鼠牙周炎骨吸收的协同作用。

光动力治疗(PDT)和抗吸收药物,如阿仑膦酸盐(ALN),已被证明可减少牙槽骨吸收。本研究的目的是评估PDT和ALN联合应用对大鼠牙周炎骨吸收的协同作用。

将60只Wistar大鼠随机分为以下组:结扎诱导牙周炎:对照组(组1); PDT(第2组); ALN 0.01 mg / kg(第3组); ALN 0.25 mg / kg(第4组); PDT + ALN 0.01mg / kg(第5组);和PDT + ALN 0.25mg / kg(第6组)。在第12天处死大鼠并取下颌骨用于宏观形态测定分析,微型计算机断层摄影术以分析骨密度(BMD)和组织学分析。取牙龈样本以评估髓过氧化物酶(MPO)和丙二醛(MDA)水平。

结果发现,在组织学研究中,从最大到最小的骨吸收和炎症活性是:对照> ALN 0.01mg / kg> PDT> ALN 0.25mg / kg> PDT + ALN 0.01mg / kg> PDT + ALN 0.25mg / kg,而从最小到最大的BMD的顺序是:对照 ALN 0.01mg / kg> PDT> ALN 0.25mg / kg> PDT + ALN 0.01mg / kg> PDT + ALN 0.25mg / kg。PDT + ALN 0.25 mg / kg治疗组的阳性结果与其他5组BMD,MPO和MDA相比有统计学差异(P≤0.05)。

PDT + ALN 0.25 mg / kg联合治疗对牙槽骨吸收有保护作用

原始出处:

F. Camacho‐Alonso, et al. Synergistic effect of photodynamic therapy and alendronate on alveolar bone loss in rats with ligature‐induced periodontitis. Journal of Periodontal Research. 2018 May. doi:10.1111/jre.12515

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    2018-12-30 feather89
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    2018-09-07 mei540
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channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101630, encryptionId=75991016300c, topicName=骨吸收)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=74d112366079, createdName=徐岩, createdTime=Wed May 23 12:26:00 CST 2018, time=2018-05-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1546307, encodeId=69f6154630ef3, content=<a href='/topic/show?id=0da528e33ce' target=_blank style='color:#2F92EE;'>#光动力#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=28733, encryptionId=0da528e33ce, topicName=光动力)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2b6213920685, createdName=luckyshitiancai_42705688, createdTime=Wed May 23 12:26:00 CST 2018, time=2018-05-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=317306, encodeId=e07631e306ef, content=光动力治疗(PDT)和抗吸收药物.如阿仑**盐(ALN).已被证明可减少牙槽骨吸收.本研究的目的是评估PDT和ALN联合应用对大鼠牙周炎骨吸收的协同作用., beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7cJ6ejWUr2nIia8qOvAKNdLHr32Df6G8iaoaOx6pHaoiacwp26DaslxZHCGbibZhhCGven4rvmWP60GahtzgFjgCjR/0, createdBy=6b111703011, createdName=有备才能无患, createdTime=Mon May 21 22:22:01 CST 2018, time=2018-05-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=317298, encodeId=900931e298a6, content=谢谢分享学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4o2XVpJ6449yqDsjibydI5HnJ8MibGxNn4HZiaZib0bdfibbwoz3KQrIyN9AGxq36ZlZRNicYlPfOOWMtwgsajY6mGNFiaPclFdowjD0/0, createdBy=97bd1338592, createdName=清风拂面, createdTime=Mon May 21 21:51:58 CST 2018, time=2018-05-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=317288, encodeId=a51931e288a3, content=学习了.谢谢分享., beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/xkvRjYnJzzRJ2R0y7VhicibvkjPWHjIMmu4ZpKnE9cWAu4lVicS3uDUCfF4M4JWvrkrYfpb2KehPV0Ee29tPqyPEebBUibiaKhnvD/0, createdBy=f8412001184, createdName=惠映实验室, createdTime=Mon May 21 21:34:29 CST 2018, time=2018-05-21, status=1, ipAttribution=)]
    2018-05-23 徐岩
  7. 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createdName=清风拂面, createdTime=Mon May 21 21:51:58 CST 2018, time=2018-05-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=317288, encodeId=a51931e288a3, content=学习了.谢谢分享., beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/xkvRjYnJzzRJ2R0y7VhicibvkjPWHjIMmu4ZpKnE9cWAu4lVicS3uDUCfF4M4JWvrkrYfpb2KehPV0Ee29tPqyPEebBUibiaKhnvD/0, createdBy=f8412001184, createdName=惠映实验室, createdTime=Mon May 21 21:34:29 CST 2018, time=2018-05-21, status=1, ipAttribution=)]
    2018-05-21 有备才能无患

    光动力治疗(PDT)和抗吸收药物.如阿仑**盐(ALN).已被证明可减少牙槽骨吸收.本研究的目的是评估PDT和ALN联合应用对大鼠牙周炎骨吸收的协同作用.

    0

  9. 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channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101630, encryptionId=75991016300c, topicName=骨吸收)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=74d112366079, createdName=徐岩, createdTime=Wed May 23 12:26:00 CST 2018, time=2018-05-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1546307, encodeId=69f6154630ef3, content=<a href='/topic/show?id=0da528e33ce' target=_blank style='color:#2F92EE;'>#光动力#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=28733, encryptionId=0da528e33ce, topicName=光动力)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2b6213920685, createdName=luckyshitiancai_42705688, createdTime=Wed May 23 12:26:00 CST 2018, time=2018-05-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=317306, encodeId=e07631e306ef, content=光动力治疗(PDT)和抗吸收药物.如阿仑**盐(ALN).已被证明可减少牙槽骨吸收.本研究的目的是评估PDT和ALN联合应用对大鼠牙周炎骨吸收的协同作用., beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7cJ6ejWUr2nIia8qOvAKNdLHr32Df6G8iaoaOx6pHaoiacwp26DaslxZHCGbibZhhCGven4rvmWP60GahtzgFjgCjR/0, createdBy=6b111703011, createdName=有备才能无患, createdTime=Mon May 21 22:22:01 CST 2018, time=2018-05-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=317298, encodeId=900931e298a6, content=谢谢分享学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4o2XVpJ6449yqDsjibydI5HnJ8MibGxNn4HZiaZib0bdfibbwoz3KQrIyN9AGxq36ZlZRNicYlPfOOWMtwgsajY6mGNFiaPclFdowjD0/0, createdBy=97bd1338592, createdName=清风拂面, createdTime=Mon May 21 21:51:58 CST 2018, time=2018-05-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=317288, encodeId=a51931e288a3, content=学习了.谢谢分享., beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/xkvRjYnJzzRJ2R0y7VhicibvkjPWHjIMmu4ZpKnE9cWAu4lVicS3uDUCfF4M4JWvrkrYfpb2KehPV0Ee29tPqyPEebBUibiaKhnvD/0, createdBy=f8412001184, createdName=惠映实验室, createdTime=Mon May 21 21:34:29 CST 2018, time=2018-05-21, status=1, ipAttribution=)]
    2018-05-21 清风拂面

    谢谢分享学习

    0

  10. 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encryptionId=f0476e49582, topicName=牙周)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ab585558129, createdName=liuyong2982, createdTime=Wed May 23 12:26:00 CST 2018, time=2018-05-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1497663, encodeId=4aaa149e66317, content=<a href='/topic/show?id=68b49e70922' target=_blank style='color:#2F92EE;'>#阿仑膦酸钠#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=40, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97709, encryptionId=68b49e70922, topicName=阿仑膦酸钠)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a5a19352939, createdName=lqvr, createdTime=Wed May 23 12:26:00 CST 2018, time=2018-05-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1532592, encodeId=93cc15325922d, content=<a href='/topic/show?id=75991016300c' target=_blank style='color:#2F92EE;'>#骨吸收#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101630, encryptionId=75991016300c, topicName=骨吸收)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=74d112366079, createdName=徐岩, createdTime=Wed May 23 12:26:00 CST 2018, time=2018-05-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1546307, encodeId=69f6154630ef3, content=<a href='/topic/show?id=0da528e33ce' target=_blank style='color:#2F92EE;'>#光动力#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=28733, encryptionId=0da528e33ce, topicName=光动力)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2b6213920685, createdName=luckyshitiancai_42705688, createdTime=Wed May 23 12:26:00 CST 2018, time=2018-05-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=317306, encodeId=e07631e306ef, content=光动力治疗(PDT)和抗吸收药物.如阿仑**盐(ALN).已被证明可减少牙槽骨吸收.本研究的目的是评估PDT和ALN联合应用对大鼠牙周炎骨吸收的协同作用., beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7cJ6ejWUr2nIia8qOvAKNdLHr32Df6G8iaoaOx6pHaoiacwp26DaslxZHCGbibZhhCGven4rvmWP60GahtzgFjgCjR/0, createdBy=6b111703011, createdName=有备才能无患, createdTime=Mon May 21 22:22:01 CST 2018, time=2018-05-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=317298, encodeId=900931e298a6, content=谢谢分享学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4o2XVpJ6449yqDsjibydI5HnJ8MibGxNn4HZiaZib0bdfibbwoz3KQrIyN9AGxq36ZlZRNicYlPfOOWMtwgsajY6mGNFiaPclFdowjD0/0, createdBy=97bd1338592, createdName=清风拂面, createdTime=Mon May 21 21:51:58 CST 2018, time=2018-05-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=317288, encodeId=a51931e288a3, content=学习了.谢谢分享., beContent=null, objectType=article, channel=null, level=null, likeNumber=57, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/xkvRjYnJzzRJ2R0y7VhicibvkjPWHjIMmu4ZpKnE9cWAu4lVicS3uDUCfF4M4JWvrkrYfpb2KehPV0Ee29tPqyPEebBUibiaKhnvD/0, createdBy=f8412001184, createdName=惠映实验室, createdTime=Mon May 21 21:34:29 CST 2018, time=2018-05-21, status=1, ipAttribution=)]
    2018-05-21 惠映实验室

    学习了.谢谢分享.

    0

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